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Can combined US examination of nail-enthesis complex & nailfold videocapillaroscopy differentiate PsA from PSO RA and HC?
Brief answer is no, but:
-PsA > tortuous capillaries vs. PSO & HC
-Abnormalities in PSO to be used as predictor of PsA?
TBC...
@RheumNow #EULAR23 POS0025 https://t.co/RNbpht8QGh
Aurelie Najm AurelieRheumo ( View Tweet)
#EULAR2023 #POS1147 Primary endpoint for Cenerimod (S1P1 modulator) phase 2 RCT in #SLE was not met after multiple testing. Post-hoc analysis showed greater reduction in SRI-4 and mSLEDAI in IFN-High vs IFN-Low at 6mths. A biomarker to stratify response in Phase 3 @RheumNow https://t.co/wKM5V1JgXT
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Fluorescence optical imaging in early arthritis?
Nice images but not ready for clinics yet
Can not differentiate OA from RA & PsA
SLE/SSc associated arthritis display a specific pattern, but usually auto-antibody profiles help w/ diagnosis
OP0173 #EULAR23 @Rheunow https://t.co/bAMi9kDKS5
Aurelie Najm AurelieRheumo ( View Tweet)
JAK inhibitors have been effective in refractory inflammatory myositis, all open label, but no controlled trials. #EULAR2023
Dr. John Cush RheumNow ( View Tweet)
Treatment of IIM, MTX or AZA or IVIG are 1st line (with steroids). #EULAR2023 https://t.co/TDKWxgrST0
Dr. John Cush RheumNow ( View Tweet)
Professor Ingrid Lundberg reviews the co associations amongst the inflammatory myopathies #EULAR2023 https://t.co/B9Idyz90Lh
Dr. John Cush RheumNow ( View Tweet)
đDoing Hands and feet Xray in undifferentiated arthritis?
Retro study 700+pts shows:
âď¸only few patients w/ UA present w/ RA-associated erosions at presentation
âď¸Rarely leads to change in diagnosis or prognosis.
Will you stop? I probably won't đ
@RheumNow #EULAR23 OP0172 https://t.co/BRpmDqaN0r
Aurelie Najm AurelieRheumo ( View Tweet)
#Lupus #nephritis - many trials and this is one company #Roche and other #pharmaceutical COâs are also involved #Hope #SLE #EULAR2023 âŚ@RheumNow⊠âŚ@eular_org⊠https://t.co/Giu2iUqq6j
Janet Pope Janetbirdope ( View Tweet)
The steroid dosing in SAPHYR (sarilumab in PMR):
Bottom two trajectories: sarilumab protocol & actual
Top two trajectories: placebo protocol & actual
Fascinating that with sarilumab, more PNL only really in play at PNL <3mg/d. Def takes the heat out
POS0715 #EULAR2023 @RheumNow https://t.co/aEC8cQaR7O
David Liew drdavidliew ( View Tweet)
RheumNowâs expanded coverage of the #EULAR2023 annual meeting is sponsored in part by Bristol Myers Squibb. All content is chosen by RheumNow and its Faculty.
Dr. John Cush RheumNow ( View Tweet)
⢠Erdheim-Chester disease (ECD) is associated with Langerhans cell histiocytosis (LCH)
⢠Bone pain, xanthelasma, hairy kidney
⢠Differential diagnoses of LCH
⢠BRAF mutation associated with cardiac and neurological phenotype of ECD
Haroche J, Papo M
#EULAR2023
@RheumNow https://t.co/AzKJKp82nq
Dr. Antoni Chan synovialjoints ( View Tweet)
What do we do with PMR patients with subclinical GCA seen on ultrasound?
Well, in these non-blinded cohorts the subclinical GCA pts got more pred.
Was it warranted? Hard to say. If weâre going to look for it, letâs try and figure out what it means
POS0712 #EULAR2023 @RheumNow https://t.co/KmCcE0Nsu9
David Liew drdavidliew ( View Tweet)
Rx of #lupus #SLE The most challenging seems to be longstanding & residual disease activity - damage accumulates over time - esp if #glucocorticoids are used. Consider only as bridging. How to treat #lupus #EULAR2023 Boumpas âŚ@RheumNow⊠#ClinicalPearl âŚ@eular_org⊠https://t.co/heBbcRAjxO
Janet Pope Janetbirdope ( View Tweet)
I mean, if proteomics is more your jive for GCA, weâve got that too here at #EULAR2023. Definite potential for phenotyping a disease with diverse outcomes
POS0694 @RheumNow https://t.co/tSWpZlUPoE
David Liew drdavidliew ( View Tweet)
Could mitochondria play a role in the pathogenesis of Sjogrens disease?!
#Eular2023 https://t.co/XndW4qFf3E
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Malt lymphoma in Sjogrens disease and role of PET scan.
When is PET scan suggestive?
Follow:
Complement
RF
Focus score
SPEP
#Eular2023 https://t.co/60l8iRNvQN
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Just a reminder: nr-axSpA isnât destined to become r-axSpA/AS. Life is more complicated than that.
Between the natural history and TNFi, very small conversion rate post-10y. Of course, whatever the x-rays, it can still disable though
DESIR cohort POS0675 #EULAR2023 @RheumNow https://t.co/29HeJXpK2S
David Liew drdavidliew ( View Tweet)
Very early days, but itâs cool to see transcriptomics in GCA âĄď¸ in situ spatial profiling âĄď¸ drug-gene interactions âĄď¸ new therapeutic targets identified.
Only time will tell if they will work, but very cool nevertheless.
POS0091 (Mayo, La Jolla, & INSERM) #EULAR2023 @RheumNow https://t.co/n7raIENVOT
David Liew drdavidliew ( View Tweet)
Iâve been hearing the term ´Jackiesâ used in talks on Jak inhibitors. A shorter form of JAKinibs or JAKi #EULAR2023 @RheumNow
Dr. Antoni Chan synovialjoints ( View Tweet)
In Brazil, if youâre in the early RA clinic (yellow bars) you do a lot better than other academic clinics, even w bDMARD access.
Maybe itâs early Rx, or love & care, or other patient factors
- but itâs a reminder that RA isnât a level playing field.
POS0055 #EULAR2023 @RheumNow https://t.co/jI2dvuIHWP
David Liew drdavidliew ( View Tweet)