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Booster Shots for Rheumatology Patients on Immunosuppressive Medications

ACR Press Release

ATLANTA – The CDC's Advisory Committee on Immunization Practices today recommended that rheumatology patients being actively treated with high-dose corticosteroids, alkylating agents, antimetabolites, TNF blockers, and other biologic agents that are immunosuppressive or immunomodulatory receive a third dose of the Pfizer-BioNTech or Moderna mRNA COVID-19 vaccines.

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RheumNow Podcast – Booster Shots for COVID (8.13.2021)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com.

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Anakinra's Effects on COVID-19 Outcomes

Jack Cush, MD

Sporadic reports of anakinra use in COVID-19 infection has hinted is potential; now a metanalysis shows that the use of anakinra may reduce the mortality risk in patients admitted to hospital with moderate to severe COVID-19 pneumonia, especially highly elevated ferritin and C-reactive prote

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COVID Vaccine Booster Effective for Transplant Recipients in Small Trial

MedPage Today

For organ transplant recipients, a third dose of Moderna's COVID-19 vaccine more than tripled the proportion with a sufficient antibody response, a randomized trial showed.

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COVID vaccine vials

Rare Risk of Serious Adverse Events After COVID Vaccination

CDC/MMWR

The CDC had reported the Advisory Committee on Immunization Practices (ACIP) study of rare serious adverse events after COVID-19 vaccination and assert that the excessive morbidity and mortality from COVID-19 (and the protection afforded by vaccination) far exceeds the risk of rare safety signals

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RheumNow Podcast – Psoriatic Arthritis Without Psoriasis (7.30.2021)

Jack Cush, MD

How much psoriasis do you need to have in order to have psoriatic arthritis? This plus a review of rheumatology and COVID news from the past week on RheumNow.com.

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CDC Reverses Stance on Masks

Jack Cush, MD

Today the Centers for Disease Control and Prevention (CDC) said that masks should be used by those vaccinated against the coronavirus in public indoor spaces in parts of the country where the virus is surging.

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DMARD Effects on COVID-19 Outcomes

Jack Cush, MD

Sparks and colleagues have published data from the Global Rheumatology Alliance noting that among rheumatoid arthritis (RA) patients afflicted with COVID-19 infection, there was little influence of their baseline biologic or targeted synthetic (b/ts) disease-modifying antirheumatic drug

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16 Pts on mech ventilation for SARS-CoV-2- induced ARDS with hyperinflammation were treated with ruxolitinib plus standard care - 13/16 survived 28 days. Better outcomes seen w/ RUX and Lymph-neutrophil ration > 0.07. https://t.co/4O2Y5swE0x

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Dr. John Cush RheumNow ( View Tweet)

In the week ending 8/12: 👧🏽121,427 pediatric #COVID19 cases (14.4% of all cases, 49 states) 🏥452 pediatric hospitalizations (24 states reporting) 💀7 pediatric deaths (43 states reporting) One death is too many.

Shematologist, MD acweyand ( View Tweet)

https://t.co/VBxg9fQmt0 Sporadic reports of anakinra use in COVID-19 infection has hinted is potential; now a metanalysis shows that the use of anakinra may reduce the mortality risk in patients admitted to hospital with moderate to severe COVID-19 pneumonia... https://t.co/XIB7OVNCvT

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Dr. John Cush RheumNow ( View Tweet)
New study data on mRNA vaccines in pts with inflammatory diseases on mostly #TNFi +/- #csDMARDs . ▶️ Effective immune response (lower than healthy controls) ▶️Comparable side effects ▶️ no ⬆️ in DAS28 ▶️ no pts on #Rituximab included https://t.co/aexdFoUzer https://t.co/h1S1S2YsHS

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ARD & RMD Open ARD_BMJ ( View Tweet)
COVID Vaccine Booster Effective for Transplant Recipients in Small Trial For organ transplant recipients, a third dose of Moderna's COVID-19 vaccine more than tripled the proportion with a sufficient antibody response, a randomized trial showed. https://t.co/iD2WFfUP3a https://t.co/eYMdocd9T4

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Dr. John Cush RheumNow ( View Tweet)
Current Israel data for mRNA vaccination in people age >60, 1st to get vaccines >6 months ago, now confronting Delta infections 1. Vaccines work but their apparent effectiveness is diminished over time + Delta 2. Boosters showing some preliminary evidence of working via @dvir_a https://t.co/YKgF9dlFz3
Eric Topol EricTopol ( View Tweet)
Today, the 5 most vaccinated states (14M people) had 580 people in hospital, 12 deaths In the 5 least vaccinated states (16M people)? 6,600 hospitalized, 104 deaths Per capita , least vaccinated states have 10X hospitalizations and 7X deaths So yeah, vaccines are working

Ashish K. Jha, MD, MPH ashishkjha ( View Tweet)

Health personnel (HCP) @ long-term care facilities (LTCFs) are at high risk for COVID-19. March 2021, 57% of LTCF HCPs were vaccinated. COVID-19 vax was highest in MDs (75.1%); lowest nurses (56.7%) & aides (45.6%). https://t.co/VjHutcrh26 https://t.co/8aO1mFgC8f

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Dr. John Cush RheumNow ( View Tweet)
ICYMI: The FDA has authorized baricitinib ALONE as treatment for COVID-19 hospitalized adults and pediatric patients requiring supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ECMO) https://t.co/WMc78GmOLU https://t.co/Bp5tL4pRk5

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Dr. John Cush RheumNow ( View Tweet)
Health personnel (HCP) @ long-term care facilities (LTCFs) are at high risk for COVID-19. March 2021, 57% of LTCF HCPs were vaccinated. COVID-19 vax was highest in MDs (75.1%); lowest nurses (56.7%) & aides (45.6%). https://t.co/VjHutcrh26

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Dr. John Cush RheumNow ( View Tweet)

The FDA has authorized baricitinib ALONE as treatment for COVID-19 hospitalized adults and pediatric patients requiring supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ECMO) https://t.co/WMc78GmOLU

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Dr. John Cush RheumNow ( View Tweet)

Persistence of Sxs & Labs long after COVID. German study of 96 postCOVID pts followed 12 mos only 22% were Sx-free; Most had fatigue (53%), dyspnea (37%), concentration (40%), CNS (32%) & sleeping problems (26%), +ANA ≥1:160 in 44% https://t.co/L2ZzniDT18

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Dr. John Cush RheumNow ( View Tweet)

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