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COVID Vaccine Booster Effective for Transplant Recipients in Small Trial

MedPage Today

For organ transplant recipients, a third dose of Moderna's COVID-19 vaccine more than tripled the proportion with a sufficient antibody response, a randomized trial showed.

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COVID vaccine vials

Rare Risk of Serious Adverse Events After COVID Vaccination

CDC/MMWR

The CDC had reported the Advisory Committee on Immunization Practices (ACIP) study of rare serious adverse events after COVID-19 vaccination and assert that the excessive morbidity and mortality from COVID-19 (and the protection afforded by vaccination) far exceeds the risk of rare safety signals

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RheumNow Podcast – Psoriatic Arthritis Without Psoriasis (7.30.2021)

Jack Cush, MD

How much psoriasis do you need to have in order to have psoriatic arthritis? This plus a review of rheumatology and COVID news from the past week on RheumNow.com.

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COVID infection mask

CDC Reverses Stance on Masks

Jack Cush, MD

Today the Centers for Disease Control and Prevention (CDC) said that masks should be used by those vaccinated against the coronavirus in public indoor spaces in parts of the country where the virus is surging.

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syringe, pill, DMARD, Treatment, therapy

DMARD Effects on COVID-19 Outcomes

Jack Cush, MD

Sparks and colleagues have published data from the Global Rheumatology Alliance noting that among rheumatoid arthritis (RA) patients afflicted with COVID-19 infection, there was little influence of their baseline biologic or targeted synthetic (b/ts) disease-modifying antirheumatic drug

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Canakinumab Fails to Improve COVID-19 Survival

Jack Cush, MD

JAMA has published the findings of trial wherein the anti–interleukin-1β antibody canakinumab (CAN) failed to improve survival in patients hospitalized with severe COVID-19.

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Rare Myocarditis Risk following COVID-19 Vaccine

CDC/MMWR

MMWR review of the risk of myocarditis and pericarditis reports a June 23, 2021 recommendation by the Advisory Committee on Immunization Practices that the benefits of COVID-19 vaccination clearly outweighed the risks of myocarditis after vaccination. 

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ICYMI: RheumNow Podcast – Tofacitinib Safety Concerns

Jack Cush, MD

Dr. Jack Cush reviews and discusses the news and journal reports from the past week on RheumNow.com.

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2020 Year Review

ICYMI: 2020 Rheumatology Year in Review

Jack Cush, MD

2020 was historic, memorable and game-changing. Under the cloud of COVID-19, there were many significant and memorable advances and setbacks for the rheumatology world. In our accounting of most read articles for 2020, (not surprisingly) 17/20 were COVID-related.

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Current Israel data for mRNA vaccination in people age >60, 1st to get vaccines >6 months ago, now confronting Delta infections 1. Vaccines work but their apparent effectiveness is diminished over time + Delta 2. Boosters showing some preliminary evidence of working via @dvir_a https://t.co/YKgF9dlFz3
Eric Topol EricTopol ( View Tweet)
Today, the 5 most vaccinated states (14M people) had 580 people in hospital, 12 deaths In the 5 least vaccinated states (16M people)? 6,600 hospitalized, 104 deaths Per capita , least vaccinated states have 10X hospitalizations and 7X deaths So yeah, vaccines are working

Ashish K. Jha, MD, MPH ashishkjha ( View Tweet)

Health personnel (HCP) @ long-term care facilities (LTCFs) are at high risk for COVID-19. March 2021, 57% of LTCF HCPs were vaccinated. COVID-19 vax was highest in MDs (75.1%); lowest nurses (56.7%) & aides (45.6%). https://t.co/VjHutcrh26 https://t.co/8aO1mFgC8f

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Dr. John Cush RheumNow ( View Tweet)
ICYMI: The FDA has authorized baricitinib ALONE as treatment for COVID-19 hospitalized adults and pediatric patients requiring supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ECMO) https://t.co/WMc78GmOLU https://t.co/Bp5tL4pRk5

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Dr. John Cush RheumNow ( View Tweet)
Health personnel (HCP) @ long-term care facilities (LTCFs) are at high risk for COVID-19. March 2021, 57% of LTCF HCPs were vaccinated. COVID-19 vax was highest in MDs (75.1%); lowest nurses (56.7%) & aides (45.6%). https://t.co/VjHutcrh26

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Dr. John Cush RheumNow ( View Tweet)

The FDA has authorized baricitinib ALONE as treatment for COVID-19 hospitalized adults and pediatric patients requiring supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ECMO) https://t.co/WMc78GmOLU

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Dr. John Cush RheumNow ( View Tweet)

Persistence of Sxs & Labs long after COVID. German study of 96 postCOVID pts followed 12 mos only 22% were Sx-free; Most had fatigue (53%), dyspnea (37%), concentration (40%), CNS (32%) & sleeping problems (26%), +ANA ≥1:160 in 44% https://t.co/L2ZzniDT18

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Dr. John Cush RheumNow ( View Tweet)

#VaccinationCovid DOES induce #SARS_CoV_2-specific #antibodies in #Rituximab-treated patients, after peripheral B-cells have at least partially repopulated! In addition, T cell responses (independent of B cell status) may also exert protective effects! https://t.co/E1FErHJtd3

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Daniel Aletaha DanielAletaha ( View Tweet)

Canakinumab Fails to Improve COVID-19 Survival https://t.co/ngThAgfHTq JAMA has published the findings of trial wherein the anti–interleukin-1β antibody canakinumab (CAN) failed to improve survival patients hospitalized with severe COVID-19. https://t.co/pUBmt85jAC

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Dr. John Cush RheumNow ( View Tweet)
152 Israeli pts w/ Breakthrough COVID infx >7d after 2nd Pfizer vax; all hospitalized, 38 w/ Poor outcome & 22% (34/152) died. All were older, most males, w/ comorbidities, 40% immunocompromised; high risk w/ RTX & low anti-spike IgG titers https://t.co/x1Uuyo7qim

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Dr. John Cush RheumNow ( View Tweet)

Vaccinated COVID-19 pts appear less contagious; report from Israel - among 650,000 received two-doses of Pfizer vaccine, 2,897 later tested positive for COVID-19, but nasal swab samples showed 4-fold less virus - hinting protection https://t.co/UBE4q5T2Ht https://t.co/OOgWoqdkdt

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Dr. John Cush RheumNow ( View Tweet)
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