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From Eye on Cytokine Storm- Decoding MAS by Dr Grant Schulert : “IL-18 is highly elevated in SJIa and other autoinflammatory disorders…can amplify innate signaling as well as induce IFN-gamma”. @RheumNow #ACR2025 https://t.co/6e5yfeDepX
Gabriela Martinez Zayas, MD MartinezZayasMd ( View Tweet)
🔥 Hot off the press
Prof John Stone shares results from Phase 3 of REPLENISH, out only a few days ago, in which secukinumab met all primary endpoints in treatment of PMR.
https://t.co/RlcQWybKrR
#ACR25 @RheumNow https://t.co/ucNt2HxJpW
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Mrinalini Dey DrMiniDey ( View Tweet)
Great to be with team @RheumNow reporting on the latest from #ACR25 https://t.co/h941qYSc6U
Antoni Chan MD (Prof) synovialjoints ( View Tweet)
REPLENISH - Secukinumab Works in Polymyalgia Rheumatica
Novartis announced the results of their REPLENISH trial showing the efficacy of secukinumab (Cosentyx) (SEC) in adults with polymyalgia rheumatica (PMR).
https://t.co/qa9RzmNFU4 https://t.co/dCEkelJzni
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Dr. John Cush RheumNow ( View Tweet)
Colchicine Ineffective in Long COVID
Management of long COVID has been perplexing with symptoms having functional and possibly inflammatory origins. Colchicine has been studied in long COVID and failed to improve functional capacity, respiratory function, or inflammatory https://t.co/9E3dvUFqJP
Dr. John Cush RheumNow ( View Tweet)
Meniscal tears - Systematic review of 46 studies
- Incidence of 66 per 100,000
- Annual cost of 5 billion to US healthcare
- Trend to preserve the meniscus, do less removal, more preservation
- Biologic Rx (platelet-rich plasma & stem cell Rx) inconclusive results https://t.co/IPyRFad9GX
Dr. John Cush RheumNow ( View Tweet)
UK National Joint Registry study of 1.5 million TKR and THA (2010 to 2022); trends show median Length of hosp stay (LOS) decreased from 4.3d to 2.75 d for THR; & from 4.35d to 2.9d for TKR; & from 3.2d to 1.9d for UKR (unilat. knee replacement). Longer LOS with comorbidity, https://t.co/DNBZTPFRsl
Dr. John Cush RheumNow ( View Tweet)
Interleukin-18 (IL-18) regulates appetite, body weight & glucose homeostasis. IL-18 deficiency may lead to obesity, but chronic IL-18 signalling promotes liver fibrosis. IL-18 is Elevated in obesity and diabetes mellitus https://t.co/Xylvexqvtg https://t.co/sRutSCoLf9
Dr. John Cush RheumNow ( View Tweet)
From the plenary to posters, RheumNow is your companion for ACR Convergence 2025. Expect:
• KOL videos
• Clinical trial highlights
• Daily faculty recaps
• Live streaming
#ACR25 #Rheumatology #ClinicalTrials https://t.co/zZAwYINmC2
Dr. John Cush RheumNow ( View Tweet)
“Never in the field of human conflict was so much owed by so many to so few.” –
Winston Churchill https://t.co/ZAcYBpOmjy
Dr. John Cush RheumNow ( View Tweet)
Review of IL-1 family cytokines in inflammation and immunity - including, IL-1, IL-18, IL-33, IL-36, IL-37, IL-38, IL-1Ra, etc. Full read -- Good Reference!! https://t.co/m2CwDydnB0 https://t.co/h90bdzv3y7
Dr. John Cush RheumNow ( View Tweet)
Whole Body MRI for Arthritis
Whole-body MRI (wbMRI) reviews have increasingly appeared in the medical literature, owing to better scanners, faster imaging times and reduced costs. Use of such non-oncologic musculoskeletal imaging provides high-contrast resolution images of the https://t.co/RQBPDhf1Vb
Dr. John Cush RheumNow ( View Tweet)
CONGRATULATIONS: Dr. Lauren Henderson has been awarded the Gale & Ira Drukier Prize in Children’s Health Research. Lauren is a pediatric rheum at Boston Children’s Hospital, focused in difficult JIA. She has studied T-B cells interactions & long-term joint damage in JIA https://t.co/uYWrh0oasy
Dr. John Cush RheumNow ( View Tweet)
Metanalysis of whole-body cryotherapy (WBC) in Ankylosing spondylitis (AS) - 5 studies & 310 #AS pts. Temps (−60°C to −10°C) & duration (80 sec to 3 min) varied. WBC significantly mproved BASDAI (p<0.001), ASDAS ( 0.015), BASFI (0.006), & VAS pain (.005), but NOT CRP https://t.co/6Sj3bg096X
Dr. John Cush RheumNow ( View Tweet)
A high ANA titer (≥1:640) in individuals without an autoimmune disease was found to be strongly associated with liver-related disorders, including nonalcoholic and alcoholic liver disease
Arthritis Care & Research
https://t.co/tkMpPFPnhc https://t.co/Bk9JXWTsOU
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ACR_Journals ACR_Journals ( View Tweet)
JAMA Pediatrics study of 1,473 young US adult, finds 1/4 use cannabis or alcohol for sleep (18% cannabis; 7% EtOH), even though these may interfere with quality or ability to stay asleep. In those using cannabis in the last yr, 41 reported using cannabis to sleep. https://t.co/fdW6bdDM3I
Dr. John Cush RheumNow ( View Tweet)
Arthritis Pain and Education Gaps Linked Save
New research from The University of Texas at Arlington shows that differences in state welfare policies are linked to rising arthritis-related joint pain across much of the U.S.
https://t.co/cGRH9X6pMZ https://t.co/J1SDeKrytn
Dr. John Cush RheumNow ( View Tweet)
Why Brittle Bones Aren't Just a Woman's Problem
Osteoporosis is more common in women, prompting routine screenings for them at age 65. As a result, men might overlook getting a scan, which may not be suggested by an orthopedic specialist. However, about 20% of men over 50 will https://t.co/ggyse5ZDPV
Dr. John Cush RheumNow ( View Tweet)
Pregnancy Management in Inflammatory Bowel Disease: A Global Consensus
Consensus guidance on the management of pregnancy in patients with inflammatory bowel disease (IBD) was simultaneously published in six international journals, including The American Journal of https://t.co/F6er2mpUoV
Dr. John Cush RheumNow ( View Tweet)
BMJ Systematic review of 217 RCTs w/ 15 684 pts shows most beneficial exercises for Knee Osteoarthritis are aerobic activities such as walking, cycling, or swimming significantly mitigated pain during both short and mid-term follow-up periods https://t.co/WmQBFNis6t https://t.co/KXv2mogvZx
Dr. John Cush RheumNow ( View Tweet)
