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Pearl: Three "S" Rule (Smoking, Seropositivity, Sex/Male): if present the risk of RA-UIP (ILD) goes up nearly 13 fold (ACR23 Abstract 1269) https://t.co/2YFosInpGs https://t.co/rOVN79JJRz

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Dr. John Cush RheumNow ( View Tweet)
How do you communicate risk/benefit to patients? @RADoctor's recent publication highlighted by Dr. H. Gabalawy at #RNL2024 -Increase awareness -Include numbers for context - Make it easy for patients to understand those numbers -Use absolute risks - Avoid 1 in X format

Dr. John Cush RheumNow ( View Tweet)

Aging in RA: "(RA is due to a poorly functioning immune system which increases a patients risk of CVD, infection, and cancer. The aging immune system additionally affects this process.

Dr. John Cush RheumNow ( View Tweet)

RheumNow Podcast square

1/600 Falls May Die (4.5.2024)

d Jack Cush, MD

Dr. Jack Cush reviews the news and Journal reports from this past week on RheumNow.com -  including problems w/ falls, pain and treatment of Dupuytren’s contractures.

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"#RNL2024 Brittany Weber on Cardio-Rheumatology: ""Everything has changed"" on inflammation and CVD - Canakinumab 150 mg v PBO HR 0.85, p =0.02 - Colchicine v PBO HR 0.69, P<0.001 2023: FDA approval for colchicine as 1st anti-inflammatory for reducing CV events

Dr. John Cush RheumNow ( View Tweet)

RA Panel

ICYMI: Top 5 Clinical Pearls in RA Management

d Rachel Tate, DO

RheumNow Live 2024 provided a wealth of clinical insights, particularly in the realm of rheumatoid arthritis (RA) management. Here are the top five clinical pearls from the event's opening session, "Success in Rheumatoid Arthritis."

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#RNL2024 ASCVD Risk Calculators underestimate risk in patients of RA Inflammatory disease was added as a "risk enhancer" in 2019 update "A low ASCVD and/or absence of symptoms may be not be reassuring" https://t.co/Cz1LRda9xx

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Dr. John Cush RheumNow ( View Tweet)

soluble Fms‐like tyrosine kinase‐1 (sFlt-1)/placental growth factor (PlGF) ratio, biomarkers of placental function and adverse pregnancy outcomes. Study of 158 RA pts, 1/2 on TNFi during Preg. TNFi assoc w/ incr birthweight; no effx on sFlt‐1 & PlGF https://t.co/JFvDxrTAfr https://t.co/CRxSEbm2Ru

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Dr. John Cush RheumNow ( View Tweet)
ICYMI: Eating for Rheumatoid Arthritis The majority of practicing rheumatologists at RheumNow Live were unaware of the new ACR guidelines issued in 2022 regarding dietary and lifestyle recommendations for patients with Rheumatoid Arthritis (RA) (1). https://t.co/0Z1lYzsxuI https://t.co/2atX1B4hQb

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Dr. John Cush RheumNow ( View Tweet)
Metrics Used by Rheumatologists in RA https://t.co/Lfzqdzehb7 https://t.co/uc5WTIdbTY

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Dr. John Cush RheumNow ( View Tweet)
#RNL2024 2022 ACR Guideline for Integrative Interventions for RA - Conditionally recommend Mediterranean diet - Conditionally recommend Against other diets or dietary supplements *Low or very low to moderate evidence due to absence of good studies 🍇🫒 https://t.co/H14pMWc1V9

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Dr. John Cush RheumNow ( View Tweet)

Monica Guma at #RNL2024 How does Mediterranean diet help inflammation? Maintains healthy microbiota Enhancing production of anti-inflammatory metabolites Maintains intestinal barrier integrity https://t.co/VoroixlV9k

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Dr. John Cush RheumNow ( View Tweet)

Seropositive RA is a spectrum to disease Hani El Gabalawy #RNL2024 Genetic and environmental factors affecting autoimmunity and leading to disease Clinical suspect arthralgias usually finds "imminent RA", may be too late at that stage for prevention https://t.co/UlQbBkMdgT

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Dr. John Cush RheumNow ( View Tweet)

#RNL2024 As we age, we gain not just wisdom, but also "Inflammaging" Immune system changes in our inflammatory cells lead to: - Poor vaccine response - High risks for infections - High risk for CVD - High risk for autoimmunity https://t.co/qePhpfozQ3 https://t.co/fZ4ZBhSLXY

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Dr. John Cush RheumNow ( View Tweet)
tomatoes olive oil and whole grains

ICYMI: Eating for Rheumatoid Arthritis

d Kathryn H. Dao, M.D.

The majority of practicing rheumatologists at RheumNow Live were unaware of the new ACR guidelines issued in 2022 regarding dietary and lifestyle recommendations for patients with Rheumatoid Arthritis. Dr. Monica Guma reviewed these guidelines during her lecture on the impact of diet on disease activity and therapeutic response.  

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ild.jpg

13 Risk Factors for RA-associated Interstitial Lung Disease

d Jack Cush, MD

Interstitial lung disease (ILD) is the most widespread and fatal pulmonary complication of rheumatoid arthritis (RA). A recent metanalysis shows the pooled prevalence of RA-ILD was approximately 18.7%. 

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epigenetics,skin,autoimmune

Epigenetics and Autoimmune Skin Disease

d EurekAlert!

The central dogma proposed that genetic information predominantly transfers from DNA to RNA during gene expression to make a functional product protein. This absolute theory has been debunked because of the influence of the environment on how genes are transcribed.

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Cohort of 158 active #RA pts (DAS28 3.6-5.6 & pain 4-7/10) found that Pain was explained by: - 27% - Inflammation (+PDUS), no FM - 27% - w/ FM - 19% - w/ both FM and inflamm - 27% (No FM, no PD) - peripheral nociceptive pain https://t.co/uM6Gw8D8D8 https://t.co/Lk0ylcBDvM

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Dr. John Cush RheumNow ( View Tweet)
Korean claims study of #RA & pregnancy (& adverse preg outcomes (APO), shows MTX or LEF use w/in 3 mos of conception assoc w/ incr. in APOs (aOR 2.14-.68). In 5728 preg: 1152 APOs, HCQ most commonly used, DMARD use decreased during preg. https://t.co/7UBsNdpRgx https://t.co/cY1N73FG8Q

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Dr. John Cush RheumNow ( View Tweet)
Secondary Sjogren’s Ups Rheumatoid Arthritis Severity A Swiss observational study has shown that RA patients with concomitant Sjögren’s disease (SjD) are more likely to have a severe RA phenotype, and be less responsive to treatment. https://t.co/4dcackIe4S https://t.co/5VZ9I7r29F

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Dr. John Cush RheumNow ( View Tweet)

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