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How Age of Onset Affects Giant Cell Arteritis
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MedPage Today
Giant cell arteritis (GCA) has a different phenotype when diagnosed late in life compared with earlier onset, a large Italian cohort study indicated.
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FRAX Tool is Suboptimal in Predicting Osteoporosis Fracture Risk in Younger Post-menopausal Women
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EurekAlert!
The commonly used Fracture Risk Assessment Tool (FRAX), which includes self-identified race and ethnicity information, and the Osteoporosis Self-Assessment Tool (OST), which does not, had suboptimal performance in determining major osteoporotic fracture risk across racial/ethnic categories in you
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The Burden of Chronic Pain in US Adults (2019-2020)
Analysis of National Health Interview Survey data shows that the incidence of chronic pain in the USA is high compared with other chronic diseases.
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Watch: RNL23 Vasculitis Faculty Panel Q&A
RheumNow Live 2023: Robert Spiera, MD, Hospital for Special Surgery Anisha Dua, MD, MPH, Northwestern University, Feinberg School of Medicine Carol Langford, MD, MHS, FACP
https://t.co/4ddqt2tAQ8 https://t.co/KIPp3rePpp
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SURPASS: SEC vs ADA for axSpA
Outcome: %pts with no radiographic progression
Not benefit- Secukinumab not better than adalimumab
Though negative study, in all groups the progression was very low (<1 mSASS) - both interventions did well! #RNL2023 https://t.co/xlw4nzrwpm https://t.co/dhhLMFQnhI
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Watch: GPA Treatment Choices
https://t.co/MU6gZrgYDr https://t.co/lT1jI9jGGS
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Colchicine does not work in Hand OA. Danish trial of 100 HOA pts (age 71 yrs) given placebo or COL 0.5 mg bid x 12wk. Finger pain improved –13·9 mm w/ colchicine vs –13·5 mm w/ PBO (NS). More adverse events w/ Colchicine (72% vs 44%) https://t.co/rfANCLcZii https://t.co/OFuMGZSvhm
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Risk factors for radiographic progression:
Men ♂️
Smoking 🚬
Active inflammation🔥
Blue collar workers 💪
HLA-B27+ 💉
Pre-existing syndesmophyte 🩻
Atul Deodhar at #RNL2023 @RheumNow https://t.co/FcwrDtOG6I https://t.co/AvRpPrg1UK
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BIOBADASER registry of 3,366 RA/AS/PsA pts on 1,2 bDMARDs saw Remission-related Biologic D/C by 80 pts (2.4%). D/C Factors: short Dz duration (OR: 0.95), no csDMARDs (OR:0.56), shorter use prior bDMARD. Less D/C w/ smoking & ACPA+ https://t.co/iUdU9iI4AZ https://t.co/TknRW6pnJR
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INBUILD study was an all cause ILD nintedanib RCT (n=663). Subanalysis of 89 RA-ILD pts showed FVC decline (@ 52 wks) was −82.6 mL/yr on NIN vs −199.3 mL/yr on PBO (p=.037). NIN diarrhea in 62%; & AE discontinuation in 24% https://t.co/nWuGx6wjB2 https://t.co/LVwy1Z5TL3
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Tuesday Night Rheumatology: POD 7: Spondyloarthritis Innovations https://t.co/eDZlgdeWGr
Dr. John Cush RheumNow ( View Tweet)
Dr. Atul Deodhar on AxSpA
- 5-40% of nr-axSpA progress to r-axSpA over 2-10 years
- is non-radiographic axSpA a misnomer?
@RheumNow #RNL2023 https://t.co/HaavCnplO0 https://t.co/3jQaxVfFBH
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Dr. Deodhar reminds us of his "3,4,5 rule" for diagnosing AS.
*Erosions in 3 or more SIJ quadrants
*BME in 4 or more SIJ quadrants
*Fat lesions in 5 of more SIJ quadrants
#RNL2023 @RheumNow https://t.co/6iAXKfZvEY https://t.co/kxqbiXVd2w
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#RNL2023 @RheumNow
Atul Deodhar:
Prevalence of AS is increasing!
Is it truly more? Or likely better recognized and diagnosed, as well as increased recognition of nr-AxSpa https://t.co/HnzRrKko75 https://t.co/CBbvFIbRoi
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Allergic Drug-Induced Arthritis
Dr. Jack Cush reviews the news and journal reports from this past week on https://t.co/iRqfkFu52z. This week we delve into some odd associations, repeat drug warnings and the consequences of antirheumatic therapies.
https://t.co/lRBaXMAgz6 https://t.co/37gIHniIEi
Dr. John Cush RheumNow ( View Tweet)
Microbiome of Hip and Knee Osteoarthritis is not "Sterile"
NGS techniques show the presence of bacterial DNA in surgical specimens of hip and knee arthritis, from patients undergoing first-time total joint arthroplasty, reports a study.
https://t.co/FIUG73x21N https://t.co/kNHgKiuxHM
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Peresolimab's Potential in Rheumatoid Arthritis
Peresolimab is a humanized IgG1 monoclonal antibody that acts as a PD-1 agonist (stimulator). The NEJM reports that PER met its efficacy primary endpont in treating patients with active RA.
https://t.co/B3tApMEWI3 https://t.co/Qi3WQkwvRd
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Medevil ruler Bermudo II ("The Gouty", in Spanish: "el Gotoso") was King of León & Galicia (982 to 999). Some campaigns were a success but he lost wars & reign, presumeably from severe gout & could no longer ride horseback, & had to travel by litter https://t.co/xxzRNUY2mv https://t.co/YQRwGixd4Y
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14 yr study #SLE (255 pts) & Lymphadenopathy. Causes: SLE (33.7%), lymphoma (0.8%) or TB (0.4%). LAD assoc w/ with fever (OR=3.3), pericarditis (4.1), membranous GN (3.6), leukopenia (2.6); NOT Wt loss, myocarditis, myositis. Bx needed to R/O lymphoma. https://t.co/WzCmtOVQWm https://t.co/rMEujVv9e2
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82 Patients with Knee OA and Severe Obesity, showed that Bariatric Surgery and Weight Loss Before TKA significantly Reduced Complications Versus TKA Alone (without Wt loss surgery). TKA was delayed 17 (vs 4 mos) in Wt loss group.https://t.co/JR3BUqthhy https://t.co/q93AI4cpK0
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