ANA+ consult (10.18.2024)
Dr. Jack Cush reviews the news and journal articles from this past week on RheumNow.com.
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NEW ONLINE POSTER: Safety of a JAKi presented at EULAR 2024!
View safety across 15,000 patient-years of data from 11 Phase 3 trials, including adult patients with RA, PsA, AS, and nr-axSpA. This poster is sponsored by AbbVie US Medical Affairs.
https://t.co/s8D2GwAy52 https://t.co/asQh1D1QQn
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Retrospective population study of 383 #AS women who were pregnant (3.8/100,000) compared to controls. AS-Preg pts more likely to be older; White, w/ higher incomes, MORE thyroid Dz, Pregs, C-Sections, gestational DM, placenta previa, more neonatal SGA, IUFD… https://t.co/pgsmKgljwx https://t.co/IMJ8CTrqhY
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Turkish retrospective review of 30 axSpA/PsA pts w/ Hx of prior malignancy and went on Rx w/ secukinumab betw 2018-2024. After mean F/U of ~ 30mo, SEC retention was 90% @12 mos & 81% @24 mos. There was only 1 local tumor recurrence w bladder carcinoma https://t.co/t7tqPtHOff https://t.co/wfAxwEsZLK
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Screening to Prevent Multimorbidity in Rheumatic Patients
A population based screening program of patients with chronic inflammatory rheumatic diseases (IRD) demonstrates that systematic screening IRD patients for multimorbidity increased preventive interventions and reduced… https://t.co/qh0mkN8HgD https://t.co/ggz5bafCMt
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Efficacy of Acupuncture for Sciatica
MedPage Today
Real Chinese acupuncture was more effective than a sham version for treating sciatica stemming from herniated spinal disks in a randomized trial conducted in China.
Patients' leg pain scores decreased by 30.8 points on a 100-point scale after 4 weeks of the genuine procedure, versus a
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Upadacitinib safety across in RA, PsA, AS, atopic dermatitis >15000 Pt-Yrs exposure. Rates (per 100PYs) of Hzoster (1.6–3.6), NMSC (0–0.8) & incr CPK (4.4–7.9) higher w/ UPA vs comparators (RA, PsA); Deaths (0–0.8), SIE (0–3.9), MACE (0–0.4), VTE (<0.1–0.4), CA, malignancies… https://t.co/OoJ5OX7JyL https://t.co/vaMVFmldEB
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Risk of Uveitis with Spondyloarthritis
A retrospective registry study shows that uveitis may be seen in 10% with the diagnosis of axial spondyloarthritis (axSpA) but becomes more common (47%) over the next 30 years of disease. The good news is that biologic therapy can… https://t.co/96rRu77Tyl https://t.co/bGHnZ7lCIm
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Dot the "i", Cross the "t" (10.11.2024)
Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com. Today’s reports suggest where to look for help, especially with regard to pain.
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World renowned faculty delivering state of the art lectures. Early bird registration for RheumNow Live is now open!
https://t.co/Yk8dKDdZie https://t.co/d14Mq2AxlI
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Artificial Intelligence in Diagnosing Sacroiliac Inflammation in axSpA
A so-called deep learning artificial intelligence (AI) algorithm for analyzing MRI scans showed "acceptable" agreement with expert human readers for detecting sacroiliac joint (SIJ) inflammation in patients… https://t.co/nKbYF603ut https://t.co/Y5IzVIG2l3
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Analgesic Prescribing in Patients with Inflammatory Arthritis
A UK cross-sectional EHR clinical practice analysis between 2004 and 2020 shows that analgesic prescribing in inflammatory arthritis (IA) patients has declined, but still remains substantial, including opioid… https://t.co/K43YERU3rf https://t.co/DRZ4r9JDSv
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Artificial Intelligence in Diagnosing Sacroiliac Inflammation in axSpA
MedPage Today
A so-called deep learning artificial intelligence (AI) algorithm for analyzing MRI scans showed "acceptable" agreement with expert human readers for detecting sacroiliac joint (SIJ) inflammation in patients with axial spondyloarthritis (axSpA), researchers said.
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Korean Claims analysis of 413 radiographic axial spondyloarthritis (TNFi exposed=75 ). Recurrent CV events = 32 per 1,000 person-years; but lower if TNFi Rx'd = 19/1000PYs. TNFi exposure significantly lowered risk of recurrent CV events https://t.co/f69SHpXZCx https://t.co/ofpg0JbrR1
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ASAS Imaging Recommendations for Suspected Spondyloarthritis
ASAS (Assessment of Spondyloarthritis International Society) has convened specialized task force to guide imaging request on patients with suspected/known axial spondyloarthritis (axSpA).
https://t.co/snSKDtToHh https://t.co/wpGSHkTwCD
Dr. John Cush @RheumNow( View Tweet )
Stop Counting Bugs (10.4.2024)
Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.This week’s rants include the microbiome, PsA treatment choices and fishing for P-values in research.
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Risk of Uveitis with Spondyloarthritis
A retrospective registry study shows that uveitis may be seen in 10% with the diagnosis of axial spondyloarthritis (axSpA) but becomes more common (47%) over the next 30 years of disease. The good news is that biologic therapy can significantly lower the risk of uveitis in (SpA).
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Taiwan claims data study compared (2003-2013) 30,911 newly diagnosed #AS pts to 309,110 controls found significantly higher risk of motor vehicle accidents w/ injuries in AS, esp. 2yrs after Dx (IRR 2.0) https://t.co/Ca0LN675oj https://t.co/UKQMgQYMAL
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Have a a rheumatology question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology.
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Which One is the Loneliest Number (9.27.2024)
Dr. Jack Cush reviews the regulatory approvals, announcements, guidelines and interesting journal articles from the past week on RheumNow. When not to use muscle relaxants, how frequent is loneliness in RA/PsA/SpA, and when to refer… https://t.co/c4YKKXbweX https://t.co/pEaA5qVvd9
Dr. John Cush @RheumNow( View Tweet )
ASAS Imaging Recommendations for Suspected Spondyloarthritis
ASAS (Assessment of Spondyloarthritis International Society) has convened specialized task force to guide imaging request on patients with suspected/known axial spondyloarthritis (axSpA).
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Pooled data from #PsA (n=914) & #AS (n=372) RCTs looked at outcomes in smokers (37% & 48%). Current or past smoking had NO EFFECT on outcomes (MDA, ACR50, ASAS40, ASDAS), but incr odds of D/C & some SAE (SIE) but not MACE, HZ, VTE https://t.co/WRflSVO3Ig https://t.co/YMI5YCT0QK
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Study of 866 #AS pts shows those w/ lower socioeconomic status (SES) had longer Dx delay, higher BME, more structural damage, & permanent disability (31% vs 13%), compared to high SES AS pts; despite similar use of bDMARDs betw groups. https://t.co/x0dfFACUz9 https://t.co/tOmhE9vGiH
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Diagnostic delay of 7.4 yrs (median 4yrs) in axSpA. An Int’l IMAS cross-sectional online Pt. survey (2017–22) 5,557 axSpA pts (27 countries). The highest delay in S Africa & lowest in Asia. Longer Dx delay assoc w/ younger age, female, rheumatologist Dx, # HCPs, & Hx uveitis… https://t.co/sqf2uamKG6 https://t.co/JUseWzbwUh
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Bimekizumab FDA Approved for Psoriatic Arthritis, Non-radiographic Axial Spondyloarthritis and Ankylosing Spondylitis
UCB announced today that the U.S. Food and Drug Administration (FDA) has approved bimekizumab-bkzx (Bimzelx) for the treatment of 3 chronic inflammatory… https://t.co/aITAeYuJxv https://t.co/tAPFfshPSs
Dr. John Cush @RheumNow( View Tweet )
Recent Blogs
With their publication in June 2022 (1), the 3rd iteration of the Group for Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) Treatment recommendations for Psoriatic Arthritis (PsA) may have set a record or sorts.
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