Psoriatic arthritis

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Psoriatic Arthritis and Pregnancy

Eric Dein, MD
Mar 20, 2023

At RheumNow Live this weekend, Dr. Christina Chambers, an epidemiologist at the University of California San Diego and the principal investigator of MotherToBaby Pregnancy Studies, reviewed the available data on psoriatic arthritis and pregnancy. There is little evidence at this time that

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@RheumNow's review of new drug approvals during 2022 at #RNL2023 https://t.co/IgndlG6lOI
Dr. Rachel Tate @uptoTate( View Tweet )
Mar 19, 2023
Biosimilars are coming! Multiple adalimumab biosimilars this year - will we see a dramatic price difference? @RheumNow #RNL2023 https://t.co/8vdtXtEGOO
Robert B Chao, MD @doctorRBC( View Tweet )
Mar 19, 2023
Biosimilar to biosimilar switching of Infliximab , ⁦@RheumNow⁩ Kavanaugh #RNL2023 Communications is a key always. Discuss with your patient always, and show them the data. https://t.co/d7Nq6LoJYQ
Nouf Al hemmadi @NoufAhmedAlham2( View Tweet )
Mar 19, 2023
Risk of adverse outcomes in PsA pregnancies More pre eclampsia More Cesarian section More preterms By Dr.Chambers #RNL2023 ⁦@RheumNow⁩ https://t.co/LRiSSpv4Yj
Nouf Al hemmadi @NoufAhmedAlham2( View Tweet )
Mar 19, 2023
Dr. Eric Ruderman with an excellent review of the JAK/STAT pathway especially for PsA treatment @RheumNow #RNL2023 https://t.co/kNDouZ4kCV
Robert B Chao, MD @doctorRBC( View Tweet )
Mar 19, 2023
#RNL2023 Year in Review COMPLETE-PsA: DMARDs for PsA! LEF+MTX better than MTX alone, 78 total patients PASDAS at week 16: 59% for MTX+LEF vs 34% MTX+PBO More treatment discontinuations (10 vs 3) in combo group due to GI intolerance @RheumNow https://t.co/3Al8PQmNli
Eric Dein @ericdeinmd( View Tweet )
Mar 19, 2023
Check out MothertoBaby fact sheets by the NIH and LactRX (by mother to baby) app for pregnancy, disease, and medications. Dr. C. Chambers highlighted this today at #RNL2023 @RheumNow

Dr. Rachel Tate @uptoTate( View Tweet )

Mar 19, 2023
#RNL2023 Year in Review Male response better than female response in patients with PsA in SELECT-PsA evaluating UPA/ADA. More targeted studies needed @RheumNow https://t.co/Z3kbM0e9A0
Eric Dein @ericdeinmd( View Tweet )
Mar 19, 2023
#RNL2023 Year in Review BE COMPLETE: P3 trial Bimekizumab for PsA in TNF inadequate responses at 16 weeks 160 mg BKZ SQ q4w vs PBO ACR50 43%, PBO 7% PASI 1000: BKZ 58.5% vs PBO 4.5% Safety: oral candidiasis: 2.6% BKZ vs PBO 0% @RheumNow https://t.co/bW00Wg6Cnf
Eric Dein @ericdeinmd( View Tweet )
Mar 19, 2023
Talk to me about candidiasis. BKZ showed increased safety signals for candida infections. I fear infxns may be under reported (after approval and in use) if patients see other physicians for treatment vs their rheumatologist/derm. Thoughts on this signal? #RNL2023 @rheumnow https://t.co/UPA5oP9G49
Dr. Rachel Tate @uptoTate( View Tweet )
Mar 19, 2023
TYK2 in plaque psoriasis By Eric Ruderman #RNL2023 ⁦@RheumNow⁩ Safer? No lab monitoring And it works https://t.co/9Woen2q4hZ
Nouf Al hemmadi @NoufAhmedAlham2( View Tweet )
Mar 19, 2023
TYK2 signalling Vs JAK signalling summary #RNL2023 https://t.co/0VNBiEc6jq
Dr Gurdeep Dulay @gurdeep_dulay( View Tweet )
Mar 19, 2023
Approach to pregnancy in patients with PsA , By Dr.Chambers #RNL2023 ⁦@RheumNow⁩ https://t.co/8tSz7qbmQU
Nouf Al hemmadi @NoufAhmedAlham2( View Tweet )
Mar 19, 2023
Prevalence of PsA in women of reproductive age, By Dr.Chambers #RNL2023 ⁦@RheumNow⁩ https://t.co/hB6QQtz7fw
Nouf Al hemmadi @NoufAhmedAlham2( View Tweet )
Mar 19, 2023
Dr. Laura Coates on PsA treatment: - Applying treat to target associated with better quality of life - low disease activity is a reasonable target Do you use PROs in managing your PsA pts? Perhaps we should @RheumNow #RNL2023 https://t.co/36n1Cp5jtP
Robert B Chao, MD @doctorRBC( View Tweet )
Mar 19, 2023
Why do PROs matter? @DrLauraCoates reviewed this slide regarding the increased survival curve in end-stage cancer patients when we monitor PROs. @RheumNow #RNL2023 https://t.co/JfHNBKJGRl
Dr. Rachel Tate @uptoTate( View Tweet )
Mar 19, 2023
29 pts w/PsA Sine Psoriasis: 16F/13M, mean age 45 yrs w/ PsA ~6.2 yrs. 54% had 1st-degree relatives with PsA. 66% had DIP arthritis, 39% polyarticular, 36% oligoarticular, 25% were axial. Nail findings seen in 89%, enthesitis 59%, dactylitis 62% https://t.co/MlnIzGBzn0 https://t.co/8hHE3Yv8UE

Links:

Dr. John Cush @RheumNow( View Tweet )
Mar 18, 2023
Preterm deliveries in PsA pregnancies were more pronounced with 1- first pregnancy. 2- Discontinuation of biologic prior to pregnancy. By Dr.Chambers #RNL2023 ⁦@RheumNow⁩ https://t.co/CxZh0ak4l0
Nouf Al hemmadi @NoufAhmedAlham2( View Tweet )
Mar 18, 2023
Neonatal outcomes: Small for gestational age more common with an Adjusted OR off 2.42 and statistically significant. By Dr.Chambers #RNL2023 ⁦@RheumNow⁩ https://t.co/NFMAEROEEM
Nouf Al hemmadi @NoufAhmedAlham2( View Tweet )
Mar 18, 2023
Pregnancy and #PsA Risk of preterm delivery if ➡️first pregnancy ➡️biologic stopped pre-pregnancy Dr Chambers at #RNL2023 https://t.co/yImZRwMuI8
Dr Gurdeep Dulay @gurdeep_dulay( View Tweet )
Mar 18, 2023
Why JAKinibs in PsA ?! By Eric Ruderman #RNL2023 ⁦@RheumNow⁩ Also inflammatory bowel disease and most recently Upadacitinib for crohns disease. https://t.co/loUgJNUsKT
Nouf Al hemmadi @NoufAhmedAlham2( View Tweet )
Mar 18, 2023
Jaks are every where in Psoriatic disease domains, By Eric Ruderman #RNL2023 ⁦@RheumNow⁩ Good news, especially with Updacitinib recently and Crohn’s disease ( full package). https://t.co/nlBWJhzpLp
Nouf Al hemmadi @NoufAhmedAlham2( View Tweet )
Mar 18, 2023
⚠️Only 12-43% of #PsA patients achieved remission or very low disease activity From systematic review in RWE presented by @DrLauraCoates #RNL2023

Dr Gurdeep Dulay @gurdeep_dulay( View Tweet )

Mar 18, 2023
Treat to target approach in PsA Systematic rev: 12-43% pts achieved target of very low disease activity or remission Pts and docs agree: remission is primary goal, but Low disease activity is acceptable alternative @DrLauraCoates at #RNL2023 @Rheumnow https://t.co/hA7JDR7Zyh
Eric Dein @ericdeinmd( View Tweet )
Mar 18, 2023

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A colleague of mine once told me an interesting story of how her father, who was a doctor, misdiagnosed his wife with fibromyalgia when she actually had psoriatic arthritis with enthesitis all along. I would venture out and say that the average physician would have trouble evaluating enthesitis because even we, as rheumatologists do!  Read Post

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