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Dr. Jack Cush reviews the FDA approvals, news and the latest journal articles from the past week on RheumNow.com.
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Both systemic onset juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease are acquired autoinflammatory disorders of uncertain etiology. Yet recent reports of AOSD onset and flare following COVID-19 vaccinations may have important mechanistic implications.
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A retrospective records review of patients with periodic fever syndromes (PFS) receiving IL-1 inhibitor treatment with canakinumab (CAN), shows CAN to be effective and safe in a variety of PFS patients.
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Patients with dermatomyositis who were positive for a myositis-specific antibody had a much higher incidence of and mortality associated with Pneumocystis jirovecii infection than patients with other antibody-negative idiopathic inflammatory myopathies, Chinese researchers found.
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The American College of Rheumatology has issued an updated version of its COVID-19 Vaccine Clinical Guidance for Patients with Rheumatic and Musculoskeletal Diseases following recent recommendations from the CDC that certain immunocompromised patients receive a third dose of an availabl
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Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com.
Article
Sporadic reports of anakinra use in COVID-19 infection has hinted is potential; now a metanalysis shows that the use of anakinra may reduce the mortality risk in patients admitted to hospital with moderate to severe COVID-19 pneumonia, especially highly elevated ferritin and C-reactive prote
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It was a banner week at the FDA; a new drug approval you should know about; a lot of information about pregnancy and safety; and an interesting case plus a question from one of our readers submitted via Back Talk. This and more in this week's podcast. Let's dive in.
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2020 was historic, memorable and game-changing. Under the cloud of COVID-19, there were many significant and memorable advances and setbacks for the rheumatology world. In our accounting of most read articles for 2020, (not surprisingly) 17/20 were COVID-related.
Dr. John Cush
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Comparative study of 46 AOSD, 9 MAS & 31 adult HLH pts, shows that serum IL-18 was signif higher in AOSD than HLH (closely correlates w/ ferritin, sIL-2R). IL-18, sIL-2R, ‘arthralgia or arthritis’ independently distinguished AOSD from HLH https://t.co/ZW6e78nEkh
Dr. John Cush
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Smoking worsens adult-onset Still’s disease. 185 AOSD pts, found 45 smokers who had higher risk of pericarditis (36 vs 16%), pleuritis (33 vs 14%), abd pain (18% vs 6%), higher systemic score (6.4 vs 5.4 ), More MAS (29% vs 6%), lung disease (18% vs 13%) https://t.co/ZKKhw1EbnD
Dr. John Cush
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Catastrophic Still's dz occurs early; compares 20 AOSD w/ organ failure vs 40 AOSD without. CAT-AOSD had shorter Dz duration, earlier Rx need; risks: younger; splenomegaly, liver, cardiac,lung involvement; ferritin level, no arthralgia https://t.co/8WIMd0JxZr
Dr. John Cush
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Are you an Expert in Still's disease, Periodic Fevers, FMF or Autoinflammatory Dz? I will add you to our expert referral listing on https://t.co/LYd3dtU295. DM me to get on the list! https://t.co/lt8YMPOpK2 https://t.co/QxXHMvayTG
Dr. John Cush
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A retrospective records review of patients with periodic fever syndromes (PFS) receiving IL-1 inhibitor treatment with canakinumab (CAN), shows CAN to be effective and safe in a variety of PFS patients. https://t.co/4lqMhE6ikx #RheumNow #RheumTwitter #medtwitter https://t.co/yThiwJhcwO
Dr. John Cush
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The CDC has reported that mRNA vaccine effectiveness against COVID-19–associated hospitalizations was sustained over 24 weeks; but there is evidence of waning protection amongst the immunosuppressed.
https://t.co/UpQjFgKTpE https://t.co/3dQ2jacwJD
ARD & RMD Open
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New study data on mRNA vaccines in pts with inflammatory diseases on mostly #TNFi +/- #csDMARDs .
▶️ Effective immune response (lower than healthy controls)
▶️Comparable side effects
▶️ no ⬆️ in DAS28
▶️ no pts on #Rituximab included
https://t.co/aexdFoUzer https://t.co/h1S1S2YsHS
Dr. John Cush
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These companies do auto-inflammatory gene testing in the USA.
@RWCSmtg https://t.co/89bWd0SiAI
Dr. John Cush
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Video: What Kind of Diet Should You be on? with Dr. Robert Chao ( @doctorRBC)
https://t.co/jqkA8vrgww
#EULAR2021 https://t.co/5mPuZWmw20
Md Yuzaiful Md Yusof
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We need to revisit #SLEDAI #lupus arthritis. Drs Mahmoud & Vital reported only 48% without swelling had MSK-US synovitis; 90% with swelling. They proposed new TERM: Inflammatory joint pain with =>2 SJC. Need to get this right as it impacts SRI-4 #EULAR2021 #POS0746 @RheumNow https://t.co/JPqOMLQ2ES
Robert B Chao, MD
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Apremilast in Behcet’s - RELIEF European subgroup analysis
⬇️oral ulcer count, ulcer pain, disease activity
⬆️QoL
⭐️results consistent with general population
Abs#POS0254
#EULAR2021 @RheumNow https://t.co/NVGt4TjkYY
