All News
Carpal Tunnel - Steroid injection vs. Night Splinting
A prospective, pragmatic, open-label, randomized trial conducted by the UK National Health Service, studied interventions in patients with carpal tunnel syndrome (CTS) and found no advantage to either CTS corticosteroid injection (CSI) or night splinting (NS) as the initial treatment of CTS.
Read Article
Marathon Running Not a Risk Factor for Arthritis
d
MedPage Today
Intensity of distance running had no bearing on the prevalence of hip and knee osteoarthritis among participants in recent editions of the Chicago Marathon, researchers reported here.
Read Article
Higher Rehospitalization Rates in Younger SLE Patients
A Medicare study shows that young adults with SLE exhibit very high 30-day rehospitalization rates (36%) that are significantly higher than older SLE patients and age matched non-SLE patients.
https://t.co/5KvpgSxhzY https://t.co/6mDPcY0tkS
Links:
Dr. John Cush RheumNow ( View Tweet)
Metanalysis of adverse PREG outcomes in 1675 women (1920 pregs) w/ anti-SSA/RO Abs - 4% preg termination, 5% spontaneous Ab, 26% preterm labor, 50% C-sect, 4% perinatal death, 3% IUGR, 7-12% heart block recurrence, 19% cut. neonatal LE https://t.co/pD2JkMsyVX https://t.co/oiSiwx9Ruj
Links:
Dr. John Cush RheumNow ( View Tweet)
In studies were glucocorticoids(GC) are used as initial bridging Rx, the odds of continuing GC 1 mo beyond expected end of GC bridging was 18% (decreasing to 7% from 6-18 mos). Initial higher doses & longer GC bridging assoc w/ higher cumulative GC doses https://t.co/6iyNVzxt1K https://t.co/TmecyFg2vB
Links:
Dr. John Cush RheumNow ( View Tweet)
10 yr study of 390 RA pts, of whom 160 (41%) had MTX-related gastrointestinal intolerance (GIS); meaning they D/C MTX and had EGD - H. pylori was significantly higher inMTX GIS pts; such pts had 3 fold higher odds of Rx w/ biologics or JAKi's https://t.co/RvrUErHyWe https://t.co/ea8Kq42oqW
Links:
Dr. John Cush RheumNow ( View Tweet)
THIS WEEKEND! Join us at RheumNow Live and hear from our keynote speaker, Miracle Larry.
Larry will share his story of surviving COVID-19 in March 2020 and becoming known as New York City's 'Miracle Larry.
https://t.co/WkB6RWZoDM https://t.co/ddBDXMR0tY
Links:
Dr. John Cush RheumNow ( View Tweet)
Big Time Vasculitis
Dr. Jack Cush reviews articles from the past week on RheumNow. This weeks highlights includes insights on scleroderma, myositis, vasculitis and answers - does aggressive biologic treatment of psoriasis prevent future PsA?
https://t.co/hDClGPOYYO https://t.co/J2hsFZAGOr
Links:
Dr. John Cush RheumNow ( View Tweet)
Annually acetaminophen is responsible for 112 000 US poison center calls, 59000 emergency department visits, and 38000 hospitalizations. Of more concern, it is the leading cause of acute liver failure in the US and other high-income countries https://t.co/5AtQAD1dKu https://t.co/ntZ8dD1srz
Links:
Dr. John Cush RheumNow ( View Tweet)
Does Methotrexate Work in Alopecia Universalis?
Alopecia areata totalis (AT) and universalis (AU) are the most severe and difficult to treat forms of alopecia areata (AA).
https://t.co/Lvd7P6r85w https://t.co/hX3rz5fBKT
Links:
Dr. John Cush RheumNow ( View Tweet)
NEJM Case: 44 yoF w/ 1wk hx of pustular rash, 1st on face, then legs. Also has ankle pain & odynophagia. PMHx oral ulcers. Exam: Aphthous ulcers & all labs were negative (ANA, ANCA, HIV, RPR, etc). Skin Bx= small-vessel vasculitis. What Dx? https://t.co/4Zw4xXxaAL https://t.co/GM3Yq70tWq
Links:
Dr. John Cush RheumNow ( View Tweet)
GCA patients with AORTITIS proven by CTA or FDG-PET/CT have higher rates of relapse. Among 82 GCA pts, 78% positive on both CTA & PET. Relapse was seen in 70% in the CTA+/PET+ group & 29% in the CTA-/PET+ (p = 0.019). https://t.co/2zU9ueWkEZ https://t.co/aFn2xH6KmI
Links:
Dr. John Cush RheumNow ( View Tweet)
Renal Involvement is Pivotal in ANCA-Associated Vasculitis
Researchers have identified four different trajectories of kidney function over time in AAV patients, with implications for personalized treatment, as well as future research.
https://t.co/JfIWmpkNiS https://t.co/72jRAVxj13
Links:
Dr. John Cush RheumNow ( View Tweet)
Systemic sclerosis current therapy:
- early dcSSc: MMF, CTX, RTX, TCZ
- rapidly progressive dcSSc - ?Stem cell transpl?
- SSc-ILD: MMF>CTX, possibly nintedanib, perfinidone
- Raynauds w/ digital ulcers: CA channel block, PDE5 inhib, iloprost, Bosentan https://t.co/z4OzFklrcl https://t.co/bM01inV2QY
Dr. John Cush RheumNow ( View Tweet)
Long-Term Benefit of Rituximab in Systemic Sclerosis
A small cohort trial of rituximab (RTX) in 29 systemic sclerosis patients showed significantly improved skin sclerosis and lung function after a follow-up of 96 weeks.
https://t.co/qrtv9eK1Oz https://t.co/GdOyaCIPUA
Links:
Dr. John Cush RheumNow ( View Tweet)
Serum beta-2 microglobulin (B2M) in 100 #SLE pts - strong correlations betw B2M & 24 hr urinary protein, BUN, creatinine, disease activity, & damage score (p < 0.001), & negatively correlated with GFR, C3, C4 (p < 0.001). B2M predicted lupus LN https://t.co/wXCs0WlIYv https://t.co/vZPWtnqIta
Links:
Dr. John Cush RheumNow ( View Tweet)
Metanalysis of 3 RCTs & 19 observational studies, showed hematopoietic stem cell transplantation . (HSCT) significantly improved skin thickness and lung function. While HSCT had more deaths than IV CTX, HSCT had higher 2 yr survival rate https://t.co/FMWFfmYPod https://t.co/SFjlj1yV0x
Links:
Dr. John Cush RheumNow ( View Tweet)
Metanalysis shows Takayasu's arteritis pts are at higher risk of adverse pregnancy outcomes. (27 studies, 825 pregs) showed more miscarriage (16%), hypertension (37%) and pre-eclampsia (14%) in TA patients (p < 0.01) https://t.co/stVx5jvPsj https://t.co/LaftdsHmSz
Dr. John Cush RheumNow ( View Tweet)
Does Methotrexate Work in Alopecia Universalis?
Alopecia areata totalis (AT) and universalis (AU) are the most severe and difficult to treat forms of alopecia areata (AA).
https://t.co/x8EjMekMBJ https://t.co/ntejSJcG5M
Links:
Dr. John Cush RheumNow ( View Tweet)
CDC says EVERYONE should be tested for Hepatitis B al least once, w/ 3 lab - HBsAg, & Abs to hepatitis B surface Ag (anti-HBs), hep B core Ag (anti-HBc). At increased risk for HBV - persons in jail, +Hx of STDs, multiple sex partners or Hx of hepatitis C https://t.co/DRzAuhVJSJ https://t.co/9ma0I61xeD
Links:
Dr. John Cush RheumNow ( View Tweet)