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Big Time Vasculitis (3.10.2023)

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d Jack Cush, MD

Mar 10, 2023

Dr. Jack Cush Reviews the News and Journal articles from the past week on RheumNow. This weeks highlights includes insights on scleroderma, myositis, vasculitis and answers the question - does aggressive biologic treatment of psoriasis prevent future psoriatic arthritis?

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Long-Term Survival of Idiopathic Inflammatory Myopathies

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d Jack Cush, MD

Mar 09, 2023

A single center cohort study analyzed the outcome and survival of idiopathic inflammatory myositis (IIM) patients and showed good 5 and 10 year survival but showed significant declined 15-25 years post-diagnosis.

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antibody (Keep)

Geo-epidemiology of Autoantibodies in Rheumatoid Arthritis

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d Jack Cush, MD

Mar 09, 2023

A multinational study of rheumatoid arthritis (RA) patients shows a variety of post-translationally modified anti-modified protein antibodies (AMPA). While AMPA differed in different ethnic populations, their levels correlated with total serum IgG.

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Higher Rehospitalization Rates in Younger SLE Patients

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d Jack Cush, MD

Mar 08, 2023

A Medicare study shows that young adults with systemic lupus erythematosus (SLE) exhibit very high 30-day rehospitalization rates (36%) that are significantly higher than older SLE patients and age matched non-SLE patients.

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alopecia,universalis

Does Methotrexate Work in Alopecia Universalis?

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d Jack Cush, MD

Mar 08, 2023

Alopecia areata totalis (AT) and universalis (AU) are the most severe and difficult to treat forms of alopecia areata (AA).

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Does Biologic Treatment in Psoriasis Reduce the Risk of Psoriatic Arthritis?

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d Jack Cush, MD

Mar 07, 2023

Retrospective claims analysis shows that psoriasis patients treated with either an IL-12/23 inhibitor or an IL-23 inhibitor had a lower risk of developing incident psoriatic arthritis, compared to TNF inhibitors or IL-17 inhibitors.

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Study of 21 Downs syndrome pts shows DS to be an autoimmunity-prone state, with a steady-state cytokinopathy, and evidence of hyperactivated CD4 T cells and ongoing activated B cells (CD11c+) - all contribute to a breach in immune tolerance. https://t.co/UUEByfBrqk https://t.co/ekq8AHYlxQ

Links:

https://go.nature.com/3JcETGy

Dr. John Cush RheumNow ( View Tweet)

Mar 09, 2023

GCA patients with AORTITIS proven by CTA or FDG-PET/CT have higher rates of relapse. Among 82 GCA pts, 78% positive on both CTA & PET. Relapse was seen in 70% in the CTA+/PET+ group & 29% in the CTA-/PET+ (p = 0.019). https://t.co/psA6hywouL https://t.co/WORiBd9Qli

Links:

https://bit.ly/3Lbped9

Dr. John Cush RheumNow ( View Tweet)

Mar 09, 2023

New PMR Paradigm Lessons from the clinic, brought to you by RheumNow Live. Join us on March 18 &19, 2023 in Dallas, TX https://t.co/4umv0FvmsQ https://t.co/iFQGIHiIds

Links:

https://bit.ly/3Yv87Wz

Dr. John Cush RheumNow ( View Tweet)

Mar 09, 2023

Does Biologic Treatment in Psoriasis Reduce the Risk of PsA? Retrospective claims analysis shows that psoriasis patients treated with an IL-12/23 inhibitor or an IL-23 inhibitor had a lower risk of developing incident PsA. https://t.co/j73V7zMnkn https://t.co/EhGUXDNNlS

Links:

https://bit.ly/3ZwAW6m

Dr. John Cush RheumNow ( View Tweet)

Mar 09, 2023

My Bum Knee QD Clinic - Lessons from the clinic, brought to you by RhuemNow Live, March 18 &19, 2023 - Dallas, TX https://t.co/nqBiAZsYGY https://t.co/MxhCbrWm3p

Links:

https://bit.ly/3JmDazK

Dr. John Cush RheumNow ( View Tweet)

Mar 09, 2023

BRIDGE-PMR a proof-of-concept trial studied 1 dose of IV RTX in 47 PMR pts - at 1 yr, 52% RTX were in GC-free remission (compared to 21% given PBO). Eight (33%) patients in the placebo group and six (26%) in the rituximab group had adverse events https://t.co/yv8ezFN5BJ https://t.co/7FOOPbEIf3

Links:

https://bit.ly/3JmDHkQ

Dr. John Cush RheumNow ( View Tweet)

Mar 09, 2023

Bullous pemphigoid is an autoimmune blistering Dz that may be seen with other hematologic dz - hemophilia A, hypereosinophilic syndrome, autoimmune thrombocytopenia, aplastic anemia, Heme malignancy (MDS, CLL, etc) https://t.co/i8WdA28hYP https://t.co/RsJMt9RTNl

Links:

https://bit.ly/3Jo7RUU

Dr. John Cush RheumNow ( View Tweet)

Mar 09, 2023

Renal Involvement is Pivotal in ANCA-Associated Vasculitis Researchers have identified four different trajectories of kidney function over time in AAV patients, with implications for personalized treatment, as well as future research. https://t.co/O8EaW2MaBx https://t.co/VApYiH66yn

Links:

https://bit.ly/3ZuTDHr

Dr. John Cush RheumNow ( View Tweet)

Mar 08, 2023

ENT involvement studied in 320 ANCA associated vasculitis pts: 65% had ENT involvement w/ median age =52 yrs, & median BVAS3 = 12. Relapse seen in 29% despite immunosupp Rx. No diff in outcomes betw pts Rx w/ oral or IV CTX or RTX https://t.co/MwZSnVVd32 https://t.co/YbrHxnqDw9

Links:

https://bit.ly/3YtLTUP

Dr. John Cush RheumNow ( View Tweet)

Mar 08, 2023

Systemic sclerosis current therapy: - early dcSSc: MMF, CTX, RTX, TCZ - rapidly progressive dcSSc - ?Stem cell transpl? - SSc-ILD: MMF>CTX, possibly nintedanib, perfinidone - Raynauds w/ digital ulcers: CA channel block, PDE5 inhib, iloprost, Bosentan https://t.co/87giuQR4YZ https://t.co/z2TPlJnu5e

Links:

https://go.nature.com/3SUle2g

Dr. John Cush RheumNow ( View Tweet)

Mar 08, 2023

Long-Term Benefit of Rituximab in Systemic Sclerosis A small cohort trial of rituximab (RTX) in 29 systemic sclerosis patients showed significantly improved skin sclerosis and lung function after a follow-up of 96 weeks. https://t.co/f68wc6lQGH https://t.co/G4PKPnJ0LJ

Links:

https://bit.ly/3ZwAvsK

Dr. John Cush RheumNow ( View Tweet)

Mar 08, 2023

I Wanna Get Pregnant https://t.co/zOkchWO3XQ https://t.co/KhY5obavkW

Links:

https://bit.ly/3mzyf5b

Dr. John Cush RheumNow ( View Tweet)

Mar 08, 2023

Managing Septic Arthritis in RA https://t.co/ccRZLCtl3S https://t.co/wS2KG1jAJl

Links:

https://bit.ly/3kLBuX2

Dr. John Cush RheumNow ( View Tweet)

Mar 08, 2023

QD Clinic - Double Positive, but Few Joints Lessons from the clinic brought to you by RheumNow Live, March 18 &19, 2023 - Dallas, TX https://t.co/jnKuJbPG7l https://t.co/SiTaAXe6II

Links:

https://bit.ly/3SXcIiZ

Dr. John Cush RheumNow ( View Tweet)

Mar 07, 2023

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