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Does Biologic Treatment in Psoriasis Reduce the Risk of Psoriatic Arthritis?

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d Jack Cush, MD

Mar 07, 2023

Retrospective claims analysis shows that psoriasis patients treated with either an IL-12/23 inhibitor or an IL-23 inhibitor had a lower risk of developing incident psoriatic arthritis, compared to TNF inhibitors or IL-17 inhibitors.

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Long-Term Benefit of Rituximab in Systemic Sclerosis

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d Jack Cush, MD

Mar 06, 2023

A small cohort trial of rituximab (RTX) in 29 systemic sclerosis patients showed significantly improved skin sclerosis and lung function after a follow-up of 96 weeks.

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Renal Involvement is Pivotal in ANCA-Associated Vasculitis

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d MedPage Today

Mar 06, 2023

Bearing in mind that renal impairment is among the worst complications of ANCA-associated vasculitis (AAV), researchers have identified four different trajectories of kidney function over time in AAV patients, with implications for personalized treatment, as well as future research.

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Systemic sclerosis current therapy: - early dcSSc: MMF, CTX, RTX, TCZ - rapidly progressive dcSSc - ?Stem cell transpl? - SSc-ILD: MMF>CTX, possibly nintedanib, perfinidone - Raynauds w/ digital ulcers: CA channel block, PDE5 inhib, iloprost, Bosentan https://t.co/87giuQR4YZ https://t.co/z2TPlJnu5e

Links:

https://go.nature.com/3SUle2g

Dr. John Cush RheumNow ( View Tweet)

Mar 08, 2023

Long-Term Benefit of Rituximab in Systemic Sclerosis A small cohort trial of rituximab (RTX) in 29 systemic sclerosis patients showed significantly improved skin sclerosis and lung function after a follow-up of 96 weeks. https://t.co/f68wc6lQGH https://t.co/G4PKPnJ0LJ

Links:

https://bit.ly/3ZwAvsK

Dr. John Cush RheumNow ( View Tweet)

Mar 08, 2023

I Wanna Get Pregnant https://t.co/zOkchWO3XQ https://t.co/KhY5obavkW

Links:

https://bit.ly/3mzyf5b

Dr. John Cush RheumNow ( View Tweet)

Mar 08, 2023

Managing Septic Arthritis in RA https://t.co/ccRZLCtl3S https://t.co/wS2KG1jAJl

Links:

https://bit.ly/3kLBuX2

Dr. John Cush RheumNow ( View Tweet)

Mar 08, 2023

QD Clinic - Double Positive, but Few Joints Lessons from the clinic brought to you by RheumNow Live, March 18 &19, 2023 - Dallas, TX https://t.co/jnKuJbPG7l https://t.co/SiTaAXe6II

Links:

https://bit.ly/3SXcIiZ

Dr. John Cush RheumNow ( View Tweet)

Mar 07, 2023

Recurrent Fevers; 3 Days at 103F QD Clinic - Lessons from the clinic, brought to you by RheumNow Live March 18 &19, 2023 - Dallas, TX https://t.co/pWrCVrxamD https://t.co/C6q9aVJ2gg

Links:

https://bit.ly/3ZtUUyH

Dr. John Cush RheumNow ( View Tweet)

Mar 07, 2023

NSAIDs in Pregnancy Dr. Jack Cush reviews the lastest journal articles, news, and FDA announcements from the past week on RheumNow. This week, the importance of IFNa, Subclinical PsA and NSAID safety during Pregnancy. https://t.co/uCKNXV1zGF https://t.co/RbutI3PBjq

Links:

https://bit.ly/3ZPisxN

Dr. John Cush RheumNow ( View Tweet)

Mar 07, 2023

Serum beta-2 microglobulin (B2M) in 100 #SLE pts - strong correlations betw B2M & 24 hr urinary protein, BUN, creatinine, disease activity, & damage score (p < 0.001), & negatively correlated with GFR, C3, C4 (p < 0.001). B2M predicted lupus LN https://t.co/XujdKvjjoS https://t.co/vl8XXQDhXM

Links:

https://bit.ly/3JiIuUw

Dr. John Cush RheumNow ( View Tweet)

Mar 07, 2023

2017 Prevalence of Psoriatic arthritis (PsA) in Sweden estimated to be 0.34% (range 0.32-0.50% across all sensitivity analyses); lower in males & w/ higher level of education. 0.24% have seen rheumatology care- 32% on b/ts-DMARDs, 41% csDMARDs https://t.co/Jh2WUYVJR2 https://t.co/ZdFVIq2iQ0

Links:

https://bit.ly/41U1Q9J

Dr. John Cush RheumNow ( View Tweet)

Mar 07, 2023

ARTIS Swedish study of Cancer in RA or PSA pts (~15k pts) starting JAKi vs TNFi. With ~2 yrs F/U, the risk of Cancer (excluding NMSC) was similar betw JAKi and TNFi (HR 0.94; 0.65 to 1.38), but more incident NMSC w/ JAKi (HR 2.12; 1.15 to 3.89) at 2 yrs https://t.co/BiPWF1T0lZ https://t.co/nrmaCGBcce

Links:

https://bit.ly/3IXVOMV

Dr. John Cush RheumNow ( View Tweet)

Mar 07, 2023

Metanalysis of 3 RCTs & 19 observational studies, showed hematopoietic stem cell transplantation . (HSCT) significantly improved skin thickness and lung function. While HSCT had more deaths than IV CTX, HSCT had higher 2 yr survival rate https://t.co/6qvLJKjFES https://t.co/VHiha5FbUJ

Links:

https://bit.ly/3mtrqSP

Dr. John Cush RheumNow ( View Tweet)

Mar 06, 2023

Metanalysis shows Takayasu's arteritis pts are at higher risk of adverse pregnancy outcomes. (27 studies, 825 pregs) showed more miscarriage (16%), hypertension (37%) and pre-eclampsia (14%) in TA patients (p < 0.01) https://t.co/kyUNgcsIPD https://t.co/KA1otftKTc

Links:

https://go.nature.com/3JfjAoV

Dr. John Cush RheumNow ( View Tweet)

Mar 06, 2023

Study of 197 AAV pts in RAVE trial (RTX vs CTX; followed by AZA) showed most serious infections (82%) occurred in 6 mos (68% Resp infx) & assoc w/ lower#s CD19+ cells. TMP/SMX prophylaxis against P. jirovecii decreased SIE rates https://t.co/oz530OkGs8 https://t.co/YFW7PD6wrW

Links:

https://bit.ly/41R6W6W

Dr. John Cush RheumNow ( View Tweet)

Mar 06, 2023

Massachusetts Medical Society workforce survey (600 MDs) shows that >half have cut back patient time, 55% admitted to burnout (more in women), & 1 in 4 physicians plan to leave medicine in the next two years. https://t.co/VUd101BrEi https://t.co/Hc6UyGMW1E

Links:

https://wbur.fm/3KXxDk8

Dr. John Cush RheumNow ( View Tweet)

Mar 06, 2023

Periodontal Mucosal Breaks Trigger RA Disease Activity Periodontal disease (PD) is more common in RA, especially those with anti-citrullinated protein antibodies (ACPAs). RA activity has been linked to the severity of PD and mucosal inflammation. https://t.co/Yx7fPMrB7v https://t.co/pH0XGPqGhJ

Links:

https://bit.ly/3EVOT5n

Dr. John Cush RheumNow ( View Tweet)

Mar 06, 2023

Drs Schett & Mackensen reported a case of refractory inflammatory myositis successfully treated with CD19 CAR T cells. 41yoM w/ +Jo-1, myositis, ILD, Raynauds, periorb edema, not responding to steroids, RTX, IVIG, tacrolimus, CTX https://t.co/DlKs3DGWNu https://t.co/M7qrcfcE2y

Links:

https://bit.ly/3kNUOTe

Dr. John Cush RheumNow ( View Tweet)

Mar 06, 2023

Study of 78 pt suspected of #GCA undergoing Temp. artery Bx and US. Nearly half (35) Dx w/ GCA. Both had similar sensitivities(69% and 63%, respectively), but specificity higher w/ biopsy (100% vs 79%). Compression sign had best diagnostic performance https://t.co/wzVqrHvfqM https://t.co/HRmfb6g7aF

Links:

https://bit.ly/3EXR0Wm

Dr. John Cush RheumNow ( View Tweet)

Mar 05, 2023

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