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RA Patients on Biologics and tsDMARDs are still High Risk

d Jack Cush, MD

A new Swedish ARTIS registry study of key safety outcomes in rheumatoid arthritis (RA) patients receiving either targeted synthetic or biological disease-modifying antirheumatic drugs (b/ts DMARDs, including Janus Kinase inhibitors (JAKi)), has been updated and affirms previously held risks.

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Best Treatments for Immune Checkpoint Inhibitor-associated Arthritis

d Jack Cush, MD

A retrospective study of cancer patients who developed immune checkpoint inhibitor-associated inflammatory arthritis (ICI-IA) shows that biologic DMARDs were more effective than conventional synthetic DMARDs (csDMARDs) in rapid control of arthritis.

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Clinical Profile of RA-associated Interstitial Lung Disease

d Jack Cush, MD

A prospective, cross-sectional analysis of patients with rheumatoid arthritis (RA) shows those with interstitial lung disease (ILD) tend to be older, obese and have a smoking history.

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Rheumatologist - Work-Life Survey Results Last week, registered Rheumatologists responded to an email survey regarding work-life balance. The following are the results from 190 respondents - 53% were male (47% female) and 94% were from the USA. https://t.co/2g7oL6ltAo https://t.co/uYv7sDyO9o

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Dr. Megan Clowse discusses the differences in pregnancy planning for men and women with rheumatic disease, with particular focus on medication use. Watch now. https://t.co/Ine8CdbZR4 https://t.co/7UnanlnQcC

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FDA FAERS study of IL-17 inhib & colitis: 388 pts w/ suspected IL-17i assoc. IBD. Median age - 42 yrs; Initial Sxs= diarrhea 91%, Abd pain 58%, bloody diarrhea 51%), & fever 36%, ^WBC 87%; Time to onset=2.9 mos. Time to remission after IL-17i D/C =4 wks https://t.co/adrtUhFj9C https://t.co/61GC5hvzYV

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Retrospective study of 42 pts w/ cocaine-induced midline or systemic vasculitis; Current cocaine use common (20/23 + urine tox, including pts who prev. deniedcocaine). Found: septal perfs (75%), oronasal fistula(15%), less(27%) systemic Sxs, 56% PR3-ANCA+https://t.co/z1Z4INRSj5 https://t.co/v9ZyZD1Lrb

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With AI and GPT-4... "The cognitive speed limit has just been lifted." - John Nosta https://t.co/mMXos8LLt6 https://t.co/imBfp37J1l

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Spanish Society of Rheumatology (SER) study finds w/ retirement of many older (male) Rheums; there are workforce shortages. Most (59.7%) of rheums in Spain are women, the majority below age 54 yrs. https://t.co/DPs0S63Aqc https://t.co/ig4kOQWmkn

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vit D shows no change in Fx Risk. Study of 20,326 Australians given placebo or vit D3 60K IU/mo. 46% women, age 69 yrs. W/ 5.1 yrs F/U - no effect on Fx risk (HR 0·94; 0·84–1·06). Fx in 5.6% of Vit D vs 5.9% in PBO (non-vertebral, major OP & hip Fxs https://t.co/cSbTS3xWrX https://t.co/Jipzw28Wn8

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Antiphospholipid Antibodies With Incident Cardiovascular Events Are antiphospholipid antibodies (aPL) associated with atherosclerotic cardiovascular (ASCVD) event risk? https://t.co/XQk17P6D2f https://t.co/y5exrsicW8

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RheumThoughts: Changing the Conversation with Patients: Lupus Join the discussion! RheumThoughts are opinion pieces from healthcare professionals. https://t.co/NcJcCZVlbE @drbags71 https://t.co/VfAqUkqLak

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RheumNow Presents Women In Rheumatology: Contract Negotiations https://t.co/nkAu5kQj2w

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TONIGHT! Tuesday Night Rheumatology addresses Contract Negotiations, featuring Andrea Liberatore, JD, Gwenesta Melton, MD, and Kathryn Dao, MD. Sign up to attend this and all of our Tuesday Night Rheumatology series. @uptoTate @KDAO2011 https://t.co/L2WMLnnJhV https://t.co/Z4kEBJHBjz

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Probiotic strain Ligilactobacillus salivarius studied in gout (as it metabolizes purines). 30 pts w/ hyperuricemia & recurrent gout were given L. salivarius or allopurinol for 6 mos. Probiotic group had less gout attacks (5/15) than controls (13/15). https://t.co/njPZdKhBxv https://t.co/YO27M8p5Ki

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April's Therapeutic Update focuses on gender differences in disease states and therapeutic outcomes. Sex Differences in axSpA and PsA, Gender Differences in Vasculitis, and Gender Differences in Counseling Patients on Reproductive Health now available. https://t.co/M9kUr44Zwj https://t.co/LFPpnLMK4D

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Commercial claims analysis shows a significant association between acne and incident #IBD (OR 1.42; 1.23-1.65), but not with the drugs used to treat acne (tetracycline-class Abx or isotretinoin) https://t.co/VSHMRw4z7c https://t.co/S2o6Xw3Mfd

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Anakinra Phase 2/3 study in severe hosp. COVID-19 pts (5/20-3/21) w/ pneumonia & hyperinflammation (incr levels IL-6, ferritin, CRP, LDH). 179 pt Rx w/ ANA or SOC - d15 need for Mech ventilation was 77% ANAK v 86% SoC (NS; RR 0.90; 0.77-1.04) https://t.co/CFcI1qTsU2 https://t.co/wAj4pHN5Dh

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Mentoring is Personal Dr. Una Makris shares her experience finding and becoming a mentor to rheumatologists. https://t.co/MEW1b0lAnE https://t.co/kxdJ3bafsr

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NEJM Clinical image: 61-year-old woman presented with a 6-month history of periorbital swelling and shoulder weakness. The physical examination was notable for erythema of the upper and lower eyelids and substantial periorbital edema. Dermatomyositis. https://t.co/1Vu1Lh37Hd https://t.co/Bh7FXDgMRx

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