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Simon Says “Don’t Do This” (1.27.2022)

d Jack Cush, MD

Dr. Jack Cush reviews this week’s journal articles, focuses on studies that should not have been done and responds to viewer questions in Ask Cush Anything.

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Rheumatic Disease - IBD Overlap

d MedPage Today

Nearly one in 10 patients with inflammatory bowel disease (IBD) also have rheumatologic disorders, meaning that specialists have to talk to each other to develop a treatment plan that works for both conditions, a researcher suggested.

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AI Passes U.S. Medical Licensing Exam

d MedPage Today

Two artificial intelligence (AI) programs -- including ChatGPT -- have passed the U.S. Medical Licensing Examination (USMLE), according to two recent papers.

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rare

VEXAS may be more common than expected

d Jack Cush, MD

A great study of a recently described rheumatologic/hematologic disorder VEXAS (vacuoles, E1-ubiquitin-activating enzyme, X-linked, autoinflammatory, somatic) syndrome recently appeared in JAMA, describing the frequency and presentations of UBA1 variant. 

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OA,biomarker

Blood Test Identifies Osteoarthritis Progression

d EurekAlert!

A new blood test that can identify progression of osteoarthritis in the knee is more accurate than current methods, providing an important tool to advance research and speed discovery of new therapies.

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Variable Pregnancy Outcomes with Belimumab in SLE

d Jack Cush, MD

An analysis of the belimumab clinical trials, the Belimumab Pregnancy Registry (BPR), and postmarketing/spontaneous reports looked at outcomes in pregnant systemic lupus erythematosus (SLE) exposed to belimumab reported there are few pregnancies and confounding disease and comorbidity factors to

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Join us on 3/18 and 3/19 in Dallas, Texas or virtually for RheumNow Live! Who is coming? https://t.co/LLUufQDhHv https://t.co/nKTN5KBtuc

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Variable Pregnancy Outcomes with Belimumab in SLE An analysis looked at outcomes in pregnant SLE exposed to belimumab reported there are few pregnancies and confounding disease and comorbidity factors to provide clear guidance for such patients. https://t.co/pkyAcE0aNr https://t.co/MB4AGmtSdp

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702 #SLE pts (age 29 yrs) from India, measured plasma 25-hydroxyvitamin-D(25(OH)D) - median levels were 22.83 (13.8–31.8) ng/ml. Low Vit D(< 20) seen in 41.5%; correlated w/ age/geography, & weak neg correlation w/ weak negative correlation w/ SLEDAI2K https://t.co/EUPqJGKAhI https://t.co/MEIL5yd64n

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Early Ph IIa study of ATI-450 (Zunsemetinib), an investigational selective MAP kinase–2 (MK2) blocker leds to a sustained antiinflammatory effect; studied in 19 RA pts w/ ACR 20/50/70 of 60%/33%/20% at wk 12. https://t.co/IyjJCgdXG2

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"Dry Synovitis" exist in juvenile arthritis pts? Study of 12 DS pts, says its different from Poly #JIA; onset 6.1 yrs, w/ polyarthritis, no palpable swelling, progressive LOM/contractures, neg ESR/CRP/RF/CCP, +MRI synovitis w/ osteochondral involvement.https://t.co/tL2G7QKBL4 https://t.co/k4QoAmTGYA

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Have a Rheumatology question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. https://t.co/RaFKTqhQjN https://t.co/hH0NcpOoyx

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Why not end your patient visit with a recitation pledging your service and commitment: "Your coming to see me to day is very important, to the both of us. I pledge to be of service to you. Together WE can certainly improve your health" https://t.co/9U95LoiDQi https://t.co/dMWunEXjWk

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Recent NEJM has reviewed arthroplasty-associated infection and PJI, noting this is a rare event; notably these infections are caused by skin microorganisms introduced during arthroplasty surgery or may be seeded post-surgically. https://t.co/DXflkGnsdK https://t.co/GgfeSSl4xJ

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Dr. John Cush RheumNow ( View Tweet)
JAK-pot Study: To Cycle or Switch after JAK inhibitor Failure? Data from 17 international registries suggest that for RA patients failing their first JAKi, it did not matter if they were cycled to another JAKi or switched to a bDMARD. https://t.co/xLZveIoaRG https://t.co/tBpJUgOqaN

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Burden of BMI on Costs of Musculoskeletal Diseases A cross-sectional global study shows a substantial impact of obesity and BMI on the health and economic impact of patients with musculoskeletal (MSK) disorders. https://t.co/EZJTnLeaOZ https://t.co/sAOQ3fuq8Z

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Subanalysis of Scleroderma Lung Study II (MMP vs CTX in SSc-ILD) showed pt reported GI reflux (~moderate) was independently associated with the change ILD and fibrosis over two years (but not so for esophageal dilation) https://t.co/6wRCM0PW2a https://t.co/uc2dfdnlhu

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Dr. John Cush RheumNow ( View Tweet)
Free read review of IL-15 - crucial for the homeostasis of NK & memory CD8 T cells; IL-15 dysregulations are important autoimmune Dz & hematological malignancies. How to target the actions of IL-15 are discussed https://t.co/yUuUIOCAC6 https://t.co/nLnC37GdMS

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Dr. John Cush RheumNow ( View Tweet)
FDA oversees US drug sales, the largest single market for pharmaceuticals globally, worth an estimated $528 billion in 2020 in public and private spending (Figure 1). https://t.co/DMwoYIIyHP https://t.co/9nGStaotrO

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Inpatient health care utilization studied in 341 #SLE pts vs 341 non-SLE. SLE had more hospitalizations (30 vs 10/100PY) and more ED visit (HR 2.71) and Hospital readmission rates (32% vs. 21%, p = 0.017) https://t.co/vsW7Ol9b4O https://t.co/hpmcFuF8Pm

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