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Diagnostic tools in autoinflammatory syndromes

Olga Petryna, MD

With broader awareness about the disease state, early diagnosis and treatment in autoinflammatory syndromes, and its life threatening complication Macrophage Activation Syndrome, remains a huge unmet need.

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physical therapy

Systemic Sclerosis and Physical Therapy

Sheila Reyes, MD

Systemic sclerosis (SSc) is a chronic fibrosing disease currently with no available cure.

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There are a number of important mimics of IgG4-RD that should be considered 🔵ANCA-associated vasculitis 🔵Multicentric Castleman’s disease 🔵Rosai-Dorfman disease 🔵Inflammatory myofibroblastic tumour 🔵Cutaneous plasmacytosis 🔵Erdheim-Chester disease 🔵Malignancy #ACR20

Chris Wincup chriswincup ( View Tweet)

Check out our article titled Undifferentiated Autoinflammatory Syndrome Called VEXAS by @RheumNow. We recap Saturday's session on autoinflammatory syndromes featuring Dr. Dan Kastner. #ACR20 https://t.co/afNK3UuZef https://t.co/qGvC2ylmjL

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Dr. John Cush RheumNow ( View Tweet)

”Somatic mutation (in UBA1) may account for a significant fraction of adult-onset inflammatory disease” says Dr. Dan Kastner. Have you seen VEXAS in your clinic? #ACR20

@RheumNow

Dr. Rachel Tate uptoTate ( View Tweet)

When diagnosing Febrile, possible autoinflammatory, Stills disorders do you order genetic testing

Dr. John Cush RheumNow ( View Tweet)

These kind of studies must be done, but this result is to nobody’s surprise! #PedsRheum Let’s keep working together to move the bar towards recognition that #sJIA and #AOSD are a single condition that can affect people of all ages! https://t.co/qzbgeKPlqw

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Michael Ombrello MichaelOmbrello ( View Tweet)

Anakinra in #Stills disease - Double blind, placebo controlled RCT in Stills disease total 12pts, 6 placebo, 6 Rx grp. All pts reached ACR70 at week 2 without fever and sustained it at 12 weeks. 5/6 reached ACR90 @RheumNow #ACR20 ABS#1633 #ACRbest https://t.co/9E4vm7WzhP
Bella Mehta bella_mehta ( View Tweet)
How comfortable do you feel managing auto inflammatory conditions?

Olga Petryna DrPetryna ( View Tweet)

How comfortable do you feel managing auto inflammatory conditions?

Olga Petryna DrPetryna ( View Tweet)

How often do you order LDH, AST and triglycerides in AOSD cases?

Olga Petryna DrPetryna ( View Tweet)

@RheumNow #ACR20 abs1151 screening for inflammatory hyperferritinemia may be feasible but requires additional info: inflammatory huperferritinemia more likely to correlate with ⬆️IL18, AST&thrombocytosis while high CRP+ferritin more often seen in infectious etiology https://t.co/wiFPXepxpz

Olga Petryna DrPetryna ( View Tweet)

How many new Adult Onset Still's Disease patients have you seen in the past year? @RheumNow #ACR20

Bella Mehta bella_mehta ( View Tweet)

European Rheum Consortium (SHARE) recommendations for Rx of systemic JIA: 1) Systemic JIA - AOSD; 2) STEROIDs, 3) IL-1 inhibitors; 4) TCZ, 5) MTX & TNFi mainly for arthritis. Should be aware of risk for MAS and ILD #ACR20 Abstr#1148 https://t.co/mgZvLKNljs

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Dr. John Cush RheumNow ( View Tweet)

What biomarker do you think is the most important in diagnosis of Macrophage Activation Syndrome/ secondary HLH @rheumnow #ACR20

Bella Mehta bella_mehta ( View Tweet)

@RheumNow #acr20 abs0098 CCL2&CCR2 may play role in inflammatory response in AOSD, high levels in active AOSD subside with six resolution. Correlate with CRP, neutrophil count& ferritin levels. Does not correlate w/ Clincial markers of disease activity

Olga Petryna DrPetryna ( View Tweet)

Interim analysis of the RELIANCE registry studying effect of canakinumab (CAN) in 80 patients w/ febrile CAPS. Efficacy of CAN assessed w/ AIDA (inflam index) showing ~70% were in low activity (<9) @ACR20 Abstr#1479 https://t.co/UC2eJbpVLM https://t.co/M71s8gXZY9

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Dr. John Cush RheumNow ( View Tweet)
Crystal Arthritis and Gout Highlights at ACR: Dr. Nicola Dalbeth Gout specialist Dr. Nicola Dalbeth from Aukland, New Zealand provides a preview perspective on crystal arthritis and gout studies and sessions at #ACR20. https://t.co/QfVSpeVXlf https://t.co/cBwKF5P5eb

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Dr. John Cush RheumNow ( View Tweet)
Autoimmune Disease Outcomes of Women with Breast Implants: A Population-Based Study https://t.co/Z6R8zRezfN #breastimplants #IMID an old chestnut

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Peter Nash drpnash ( View Tweet)

Reducing Immunogenicity of Pegloticase (RECIPE) w/ concomitant use of MMF in pts w/ refractory gout is a phase II double blind RCT that shows sustained serum urate lowering effect in addition to decrease in monthly rate of flares. #ACRbest #Abst0952 @RheumNow Practice changing? https://t.co/Z7GwCXZftE
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
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