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Infection and Rheumatic Diseases: A New Dawn

Mrinalini Dey, MD

Infection in the setting of autoimmune rheumatic disease (ARD) has been the subject of increasing research and clinical interest for decades. Despite the huge burden of infection in patients with ARDs, this area of research has really been catapulted to the centre-stage of research agendas and coverage at congresses, including ACR 2020, with the arrival of the coronavirus disease 2019 (COVID-19) pandemic.

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ACR 2020 Your Way - Get Your Topic Emails

Jack Cush, MD

ACR is but a few days away; the question is: how will you tackle this virtual meeting? RheumNow has created several options for learning the way you want to. First is to feed your need. Are you a lupologist? A gout maven? A Spondylitis sleuth? A drug safety wannabe?

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IL-1 Inhibition Alters Arthroplasty Rates

Jack Cush, MD

A subanalysis of the CANTOS trial suggests that inhibition of interleukin-1β (IL-1β) can reduce rates of incident hip or knee replacement (THR/TKR) surgeries.

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Methotrexate-Pegloticase Combination in Refractory Gout - MIRROR Study

Jack Cush, MD

The MIRROR study, an open-label pilot trial in refractory, uncontrolled gout patients, showed that pegloticase given in combination with methotrexate was safe and effective and maintained responses for 6 months after initiation. 

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Get the highlights on the opening day of #ACR20. Listen in to faculty reports and overviews. Follow the link below or find us on Apple podcasts under RheumNow Podcast. https://t.co/qDQzCAHsHi https://t.co/9nM19ZdHQQ

Links:

Dr. John Cush RheumNow ( View Tweet)
DECT in #gout: color-coded lesions at MTP1 jt & patellar tendon exclusively pure MSU depositions. CCDL in gout: both pure MSU & calcium-containing depositios. @RheumNow #ACR20 Abs#0445 https://t.co/7zudk2muBR
sheila RHEUMarampa ( View Tweet)
RheumNow’s expanded coverage of the #ACR20 Annual meeting is sponsored in part by @Novartis. All content chosen by RheumNow & its Faculty.

Dr. John Cush RheumNow ( View Tweet)

@RheumNow #ACR20 abs0083 Whole exome sequencing & HLA allele prediction in 43 Irish CNO pts show increased association w/HLA-B*27:05 (+in 17.5% pts vs 6% of the Irish population). 18.6% w/personal &18.6%family Hx of PSO. 88% of cases w/multifocal disease, 51% failed 1st line Rx

Olga Petryna DrPetryna ( View Tweet)

Following promising data presented at today's poster session, results from RELIEF #Behcets study show #apremilast leads to ↓ rates of new/recurrent/worsening oral ulcers, skin lesions & #arthritis compared to placebo at 12wks. Abs#0512 #ACR20 @RheumNow https://t.co/O1dstY5WlL https://t.co/0djnUGw0Hg

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Mrinalini Dey DrMiniDey ( View Tweet)
Prof Hatemi report on apremilast in Behcets disease. We know it improves oral ulcers. Now shown to improve skin lesions and arthritis. @rheumnow #ACR20 Abstr#512 https://t.co/BwIqio6dzq
Richard Conway RichardPAConway ( View Tweet)
15 % of Relapsing Polychondritis meet diagnosis for MAGIC syndrome (Mouth and genital ulcers with inflamed cartilage) - overlap of RP and Behcet's Abst#0425 #ACR20 #ACRbest @RheumNow https://t.co/qaHWwOOL7Q
Bella Mehta bella_mehta ( View Tweet)
RheumNow’s expanded coverage of the #ACR20 Annual meeting is sponsored in part by BMS, @HorizonNews , @SanofiGenzyme, @Novartis. All content chosen by RheumNow & its Faculty.

Dr. John Cush RheumNow ( View Tweet)

COVID-19 use of dexamethasone- why does it work? When to use it ?Is it hyperferrintemic sepsis? Vs early MAS vs? More data needed but this why rheumatologists are needed!!! @RheumNow #ACR20 thank you dr. Rubin! https://t.co/MvQJGqsqu2
alexa meara lexmeara ( View Tweet)
One of the many HOT sessions tomorrow #ACR20 I am planning on - IFN is center stage in autoinflammatory/autoimmune/infectious diseases especially-hope they cover IFN autoantibodies!! #COVID19 - @CCalabreseDO @JYazdanyMD @canallab @MaxKonigMD @AdamJBrownMD @TiphaineLft https://t.co/uDauMkGsjX
Leonard Calabrese LCalabreseDO ( View Tweet)

Systematic review of the literatures (19 studies, 241 138 participants) shows ibuprofen vs acetaminophen for fever or pain in children <2 years was associated with equivalent safety and improved temperature and pain within the first 24 hours https://t.co/4y5dww22Gw

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Dr. John Cush RheumNow ( View Tweet)

Population study of 11 million, shows incidence of OPTIC NEURITIS is 3.7 /100K Pt-Yrs. Strongest association with multiple sclerosis (MS) and weaker associations with Behçet disease, sarcoidosis, and Sjögren syndrome. https://t.co/LVw0fcq1F1

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Dr. John Cush RheumNow ( View Tweet)

QD Video - I'm Not Stupid (IgG4) - Lessons from the clinic. Dr. Jack Cush discusses an IgG4 case and the power of discussion https://t.co/RDIVEeyqxW

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Dr. John Cush RheumNow ( View Tweet)

Juvenile localized scleroderma was Rx w/ MTX or MMF (in MTX refractory) and compared retrospectively. Facial linear scler. more likely in MTX pts and MMF pts had pansclerotic morphea or mixed subtype. Outcomes were same at 9.4 yrs: inactive in 100% & 91% https://t.co/2X9SpqeLwx

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Dr. John Cush RheumNow ( View Tweet)

Studies of inflammasome generated kinase activity (using UCN-01-mediated inflammasome activation) shown to discriminate familial Meditteranean fever patients from healthy donors and other inflammatory disorders https://t.co/euThYpSQMx

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Dr. John Cush RheumNow ( View Tweet)

Excellent review of IgG4-RD, @NatRevRheumatol IgG4-RD is indolent (afebrile, etc) but 60% of pts have irreversible damage at dx! Universal response to GC but 40% not in remission at 1yr; B-cell tx can bring about "dramatic response" Good read & topic: https://t.co/Mbrq7bFHk0 https://t.co/8oQF08qzit

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Mike Putman EBRheum ( View Tweet)
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