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lupus SLE

CXCL5 Therapy in Lupus?

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d EurekAlert!

Dec 14, 2022

A new study has shown that restoring the balance of a protein in blood may be a promising treatment option for systemic lupus erythematosus.

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Marginal Benefit with Diet and Exercise in Obese Knee Osteoarthritis Patients

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d Jack Cush, MD

Dec 14, 2022

The easiest intervention for knee osteoarthritis (diet and exercise) is also the most difficult for many patients; but do these work? A new study of a weight loss and exercise program in community settings shows only marginal benefits.

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Efgartigimod Treatment in Chronic Primary ITP

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d EurekAlert!

Dec 13, 2022

Patients taking efgartigimod, a drug being studied for use to treat chronic primary immune thrombocytopenia (ITP), exhibited a significantly greater improvement in platelet counts which are essential to clotting and stopping bleeding, compared to those taking a placebo, according to results repor

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Substandard Therapy in Rheumatoid Arthritis

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d Medpage Today

Dec 13, 2022

Clinicians could improve outcomes in their patients with rheumatoid arthritis (RA) by paying attention to certain markers of care quality, such as early referral to certified rheumatologists and prescribing standard drugs for RA, new research suggested.

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Efgartigimod Treatment in Chronic Primary ITP https://t.co/iJMeG2CJJv https://t.co/OXE7CuScBC

Links:

https://bit.ly/3huFlps

Dr. John Cush RheumNow ( View Tweet)

Dec 14, 2022

Substandard Therapy in RA Clinicians could improve outcomes in their patients w/ RA by paying attention to certain markers of care quality, like early referral to certified rheumatologists and prescribing standard drugs for RA, new research suggested. https://t.co/Ln6XQHLVJE https://t.co/454Ff8dEr8

Links:

https://bit.ly/3UTVh2m

Dr. John Cush RheumNow ( View Tweet)

Dec 14, 2022

Practical Guidance for the Clinical Rheumatologist in Unplanned Pregnancies Women of reproductive age comprise an overwhelming majority of patients with rheumatic and musculoskeletal disease. https://t.co/45ABQ0e2Qy https://t.co/dhLqzjf9uL

Links:

https://bit.ly/3Wfk8yF

Dr. John Cush RheumNow ( View Tweet)

Dec 14, 2022

NIH has granted $4.7 million to fund OHSU/UAB/UNC scientists to develop Novel 2-Pyrimidone (SRI-42718) Chikungunya antiviral drug. 2022: >360,000 Chikungunya cases w/ 77 deaths (mostly Brazil, India Guatemala) w/ 13 acquired in U.S. https://t.co/5ospHoFBBQ https://t.co/E1WKvdhaUO

Links:

https://bit.ly/3FNNG0W

Dr. John Cush RheumNow ( View Tweet)

Dec 14, 2022

Swedish study of 4033 incident RA vs 6485 controls - Exposure to occupational inhalable increased risk ACPA+ RA (OR 1.25). Occupational inhalable agents plus smoking and shared epitope markedly elevated risk (OR 18.22) esp in ACPA+RA https://t.co/4lKLEhkURm https://t.co/HFhz8lMR10

Links:

https://bit.ly/3Fguo2E

Dr. John Cush RheumNow ( View Tweet)

Dec 14, 2022

Study of 172 febrile pts w skin rash + arthralgia; 112 Dx w/ #AOSD. Use of a "streamlined diagnostic process (looking @ neutrophilia, hyperferritinemia, high IL-18), shortened Dx time (2 vs 4 wks), earlier Dx and more remissions (85% vs 68%, p < 0.05) https://t.co/MSMq2XLeYA https://t.co/ECKkeVqTIW

Links:

https://bit.ly/3PorJsk

Dr. John Cush RheumNow ( View Tweet)

Dec 14, 2022

Biosimilar Bonanza in 2023 Dr. Jack Cush reviews more than a dozen news and journal articles from this past week on RheumNow https://t.co/FILyCcSThn https://t.co/kBxzZgs6rM

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https://bit.ly/3PpLLD0

Dr. John Cush RheumNow ( View Tweet)

Dec 13, 2022

2022 ACR/EULAR Giant Cell Arteritis Classification Criteria Giant cell arteritis (GCA) has historically been a clinical diagnosis (visual loss, headache, jaw pain, scalp tenderness, etc) supported by labs and histopathology. https://t.co/inHKcdXLmD https://t.co/g9v1zWkmRp

Links:

https://bit.ly/3HzprVA

Dr. John Cush RheumNow ( View Tweet)

Dec 13, 2022

Small, open label study of 43 RA pts Rx w/ csDMARDs randomized to denosumab or PBO x 24 weeks. Erosions of MCP 2,3 assessed by HR-pQCT shows no significant differences in erosions or safety signals at 6 mos between groups. https://t.co/AuysVPFD4S https://t.co/yQ4R41hSMi

Links:

https://bit.ly/3URw6NO

Dr. John Cush RheumNow ( View Tweet)

Dec 13, 2022

FROST study (First-line options sJIA Tx) - a prospective study to assess treatments in SJIA. 86% Rx w/ biologic (IL-1/IL-6 i) & 14% non-biologic Rx. oral GC used in 54% biologic & 90% of non-biologic. 1/2 non-biologic went onto biologics w/in 4 mos. https://t.co/8TMpEPgzOr https://t.co/N8laSs5rrZ

Links:

https://bit.ly/3uLfZqA

Dr. John Cush RheumNow ( View Tweet)

Dec 13, 2022

The Best Prescription The craziest question that you can ask any doctor is “what is your best therapy for __?”. Crazy, because there are exponential answers, with factored layers that make each decision unique to that doctor. https://t.co/iX8T6NSD00 https://t.co/8VUPbDjXzr

Links:

https://bit.ly/3uNwAKd

Dr. John Cush RheumNow ( View Tweet)

Dec 13, 2022

73-87% of autoimmune (RA, SLE, UCTD, APL) pts used HCQ during pregnancy. HCQ significantly reduced pre-eclampsia (20% vs 9%), early-onset pre-eclampsia (8% vs 2.5%), 2nd/3rd trimester pregnancy loss (3% vs. 0.6%) https://t.co/KrA3XtGNmK https://t.co/HwpmipgJYC

Links:

https://bit.ly/3HzTyw2

Dr. John Cush RheumNow ( View Tweet)

Dec 13, 2022

From a cohort of 689 SLE pts, prevalence of lupus pericarditis was 16.4% Pericarditis was signif assoc w/ renal dz (p 0.003), lymphopenia (p <.0001), thrombocytopenia (p 0.004), +APL Abs (p = 0.002) https://t.co/BndDu21aXF https://t.co/Umbq3rsF1y

Links:

https://bit.ly/3FHTWqZ

Dr. John Cush RheumNow ( View Tweet)

Dec 12, 2022

207 JIA pts to rheumatology studied. Initially 61% seen by Pediatrics but only 28% referred to rheumatologist. Mean time to Dx was 56 days, but longer for polyarticular & ERA/SPA (~114 d). Faster dx w/ Younger age & fever; longer w/ sm jts https://t.co/5D8wiGxnC2 https://t.co/1n9S4JUdfF

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https://bit.ly/3iYMBKU

Dr. John Cush RheumNow ( View Tweet)

Dec 12, 2022

Retrospective study in RA shows Red cell distribution width (RDW) & absolute lymphocyte count (ALC) predict 10 yr mortality (P < 0.001); highest with both high RDW and low ALC. Data developed on 327 VA RA pts & validated on national cohort (13,914) https://t.co/aBGECUfKGH https://t.co/qkvv1PmvSB

Links:

https://bit.ly/3FLzUfj

Dr. John Cush RheumNow ( View Tweet)

Dec 12, 2022

Review of the Rheumatic causes of Pericarditis and their management. Causes: SLE, RA, MCTD, Myositis, EGPA, GPA, IgG4-rel Dz, FMF, TRAPS, CAPS, AOSD, JIA, Sarcoidosis, Kawasakis, GCA, Takayasu's https://t.co/h6zpTOIuyu https://t.co/Gy3Eaqz8sM

Links:

https://bit.ly/3BsYqiW

Dr. John Cush RheumNow ( View Tweet)

Dec 12, 2022

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