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ACR 2022 - Day 1 Report
The masses have returned to ACR22, a live, face-to-face, and virtual, meeting that began Saturday in Philadelphia. There were hassles and glitches, yet the education and sessions were as you’d expect with many good presentations worth recapping.
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SLE, Sex and STDs
Once in a while, I find an abstract at the ACR meeting that can potentially save lives and be implemented in practice now.
In Abstract #0939, Dr. J Patricia Dhar and colleagues shared data from a pilot study examining a new method to monitor cervical health in African American Women with Systemic Lupus Erythematosus (SLE) using a self-sampling brush to assess cervical cytology and human papilloma virus infection.
Opioid use in adults with PsA and AS
Abstract #0402 @RheumNow #ACR22
✋828 PsA patients ➡️ 21% used opioids
🦴 334 AS patients ➡️ 27% used opioids
💊Opioid users had more comorbidities, more medical visits, worse disease activity, and higher prevalence of 🚬
Catherine Sims, MD DrCassySims ( View Tweet)
Manansala et al. Baseline lymphopenia negatively predicts disease severity in sarcoid. It is protective for decline in FBC. @RheumNow #ACR22 Abstr#0830 https://t.co/Q4fE9LoG9L https://t.co/Tt1PyYLfWu
Richard Conway RichardPAConway ( View Tweet)
Ross et al. Comorbid liver disease significantly attenuates CRP rise with disease flare. Increased BMI increases CRP rise. @RheumNow #ACR22 Abstr#0811 https://t.co/O3PsDfbCMV https://t.co/9xAqWTJqkf
Richard Conway RichardPAConway ( View Tweet)
Fat and bone health are related via adipokines (fat hormones).
Data from VA registry of RA pts:
clear relationship between elevated adipokines & osteoporotic fracture risk.
This is why body fat should be a target for osteoporosis management
ABST0889 @PennRheum #ACR22 @RheumNow https://t.co/BoP8d4sooZ
David Liew drdavidliew ( View Tweet)
Vural et al Rituximab biosimilar switch in GPA. Essentially it is the same. @RheumNow #ACR22 Abstr#1072 https://t.co/OBOMz35soX https://t.co/dPdcWQmBzd
Richard Conway RichardPAConway ( View Tweet)
Soussi et al. Over last 20 years, 5-year all-cause morality decreased in RA and controls in Danish study. But to greater extent in RA, narrowing mortality gap. @RheumNow #ACR22 Abstr#0711 https://t.co/JRh37u3uGm https://t.co/bA3Y5FLcRZ
Richard Conway RichardPAConway ( View Tweet)
Have you heard of MyPROSLE (available at https://t.co/a4zlBtwaaC)? Abs 0329 details MyPROSLE's molecular characterization of individual SLE pts and it's extraction of key molecular information to support more precise therapeutic decisions. #ACR22 @RheumNow https://t.co/FslQCVvptw https://t.co/NNlgZvllPC
Links:
Dr. Rachel Tate uptoTate ( View Tweet)
🔥ignite session🔥
❓Vessel wall MRI superior to TA-US in c-GCA❓
🔥In c-GCA vessel wall MRI examines beyond the temporal arteries -
✅more 🧠 cranial arteries, including occipital arteries and the all important 👁 orbital structures
Abst#0473
#ACR22 @RheumNow https://t.co/z8hYmqc95I
Patricia Harkins DrTrishHarkins ( View Tweet)
Carter et al. Case series showing rapid effect of anifrolumab in refractory discoid lupus and SCLE. @RheumNow #ACR22 Abstr#0974 https://t.co/Od1PXzJKQh https://t.co/Hk8mrblGMX
Richard Conway RichardPAConway ( View Tweet)
Ab2126 #ACR22 Risankizumab on Enthesitis/Dactylitis
KEEPsAKE 1&2 - RZB v PBO
1407 pts -baseline 63% enth, 28% dact, 20% both
Wk 24: 14% decr. enthesitis, 17% decr dact, 13% decr both
Mean time to resolution decreased
Results maintained through wk 52
@RheumNow https://t.co/RBubeuJoh8
Eric Dein ericdeinmd ( View Tweet)
Frey @CaoilfhionnMD @JuliePaikMD et al. Increasing duration of hold of MMF (esp >=10 days) increased response to SARS-CoV-2 vaccine. No difference in disease flare rates. @RheumNow #ACR22 Abstr#0797 https://t.co/5nxo2nLg80 https://t.co/sx1Roxngx9
Richard Conway RichardPAConway ( View Tweet)
In this prospective cohort study by Dr Jacquez, there was a statistically significant inverse assoc bet. average yearly HCQ dose and overall damage accrual 👇
Reassuring data.
☝️HCQ consistently proves to be a beneficial drug for #lupus
#ACR22 @Rheumnow ABST#0982 @rheumarhyme https://t.co/nWHS9JtEsH
sheila RHEUMarampa ( View Tweet)
Pedersen @EBRheum et al. 203 RCTs, 35 (17.2%) remained unpublished more than 30 months after completion. Cited reasons: ongoing preparation/review of paper (50%), sponsor/funder problems (40%), unimportant/negative result (20%).@RheumNow #ACR22 Abstr#0827 https://t.co/V2a48iiAcn https://t.co/FLqQhjvlOx
Richard Conway RichardPAConway ( View Tweet)
#ACR22 Abstr#0825 Can we identify predictors of deaths in patients presenting with Macrophage Activation Syndrome? A cohort study (N=43) reported MAS was mostly secondary to disease. 10/43 died. Super high Ferritin and raised Ferritin/CRP ratio were assoc with deaths @RheumNow https://t.co/JCH30pi4Vf
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Boekel et al. Omicron variant assoc lower risk of severe COVID-19 in rheumatic disease than prior variants EXCEPT rituximab treated patients. @RheumNow #ACR22 Abstr#0705 https://t.co/57Boj4SEt5 https://t.co/d2NoX83y5l
Richard Conway RichardPAConway ( View Tweet)
Mendel et al. Use of TMP-SMX prophylaxis in GPA from MarketScan and Medicaid. Used in <25% treated with RTX!? Female sex negatively assoc (OR 0.61)!? Steroid use in month prior associated (OR 4.31) @RheumNow #ACR22 Abstr#1071 https://t.co/56a0nHR8o4 https://t.co/5LygdFMrss
Richard Conway RichardPAConway ( View Tweet)
Kifayat et al. Response to Shingrix in rheumatic disease patients. 3/3 PsA, 5/6 SLE, 2/14 RA pts reached protective level of 150U/ml. IgG titres and SI are 3x lower compared to non-rheumatic patients. @RheumNow #ACR22 Abstr#0800 https://t.co/Gm7ldxK5xd https://t.co/BlHuU2Jxk2
Richard Conway RichardPAConway ( View Tweet)
I was schooled for exams, testing fine motor function with a buttonhole: felt contrived.
Imagine an electrical glove for RA pts, doing functional assessment properly
Italian study: engineered glove data + HAQ correlates with DAS28
Consistent/scalable!
ABST0904 #ACR22 @RheumNow https://t.co/4ZR0An5N9j
David Liew drdavidliew ( View Tweet)