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Preview of what is sure to be discussed more in detail later..
MIRROR trial of MTX co-administration with pegloticase in treatment of gout.
MTX co-administration improved control of gout, reduced infusion reactions
@RheumNow #ACR22 https://t.co/r0MEq1rkgO
Robert B Chao, MD doctorRBC ( View Tweet)
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ACR year in review: a summary of latest FDA approvals in spondyloarthritis by C. Langford
#ACRyearinreview #ACR22 @RheumNow https://t.co/u5TyRdQM7L
Aurelie Najm AurelieRheumo ( View Tweet)
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Dr. C Langford on #YearinReview: ORAL Surveillance noted NNH=16 in pts w/ASCVD compared to NNH 223 in pts w/o ASCVD. This led to FDA warning on all JAKi; how does not this apply to the new JAKi's? Discussion needed with patients when starting this class of drug #ACR22 @rheumnow https://t.co/XtJVap6yjh
TheDaoIndex KDAO2011 ( View Tweet)
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Year in review #ACR22
IVIG received FDA approval for dermatomyositis in 2022!
@RheumNow
Bella Mehta bella_mehta ( View Tweet)
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Year in Review #ACR22
IVIG received FDA approval for adult dermatomyositis, shows benefit versus placebo
First approved Rx for inflammatory myositis
@RheumNow https://t.co/T6qVTQQdTp
Eric Dein ericdeinmd ( View Tweet)
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Good rundown of the PRODERM trial, published @NEJM earlier this year and on my podcast (https://t.co/PzEDiBdJZn) a few eps back
I disagree w/Dr. Langford re:role in therapy. I use IVIG first line for most all pts w/myositis, grateful for the FDA approval!
#ACR22 @RheumNow https://t.co/BfHZm4Kl49
Mike Putman EBRheum ( View Tweet)
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Folle et al propose a neural network to differentiate RA+ & RA- vs PsA w/ AUROC 75% & 67% for RA+ vs RA- in 5 distinct hands MRI sequences. Question: what was the performance of the rheumatologist or radiologist?
https://t.co/93aZKPlKsO
Abstr#0242 #ACR22 @Rheumnow https://t.co/uk2c3gbAOT
Aurelie Najm AurelieRheumo ( View Tweet)
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Year in Review #ACR22
CAR T cells: deep depletion of CD19 leading to immune reset
5 patients with active SLE
Normalizations of complements, dsDNA
Drug free remission
3 will mild immune reconstitution symptoms, 1 received tocilizumab
@RheumNow
Eric Dein ericdeinmd ( View Tweet)
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Nice chart w/JAKs/TYKs by drug and by cytokine pathways
In reality there is a fair bit of crossover and "selectives" aren't nearly as selective as this implies
Helpful to add deucravacitinib to the list! Looking forward to upcoming plenary
#RheumNow #ACR22 #YearInReview https://t.co/MERzpvrFB9
Mike Putman EBRheum ( View Tweet)
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Nice summary slide of JAK inhibitors and the history of JAKi in rheumatology,
#ACR22 #ACRambassador https://t.co/Ij2D7YikjT
Vaneet K Sandhu, MD, RhMSUS (she/her) vksandhumd ( View Tweet)
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Day 1 #ACR22. Tips to avoid burnout: stretch your legs, a change in scenery for virtual attendees, replenish your sweets and savoury and importantly keep your furry friend happy 🐈⬛ #PetsAtACR @RheumNow #RheumPix https://t.co/opGVSjxLjE
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
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#acr22 The Rise of JAK in rheumatology
Look for Ab1117 in plenary 2 tomorrow for DEU and SLE
@RheumNow https://t.co/nLpXGyrhfJ
Eric Dein ericdeinmd ( View Tweet)
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Dr. C Langford #YearinReview: RDBPCT on benefits/harms prednisolone 5 mg/day for 2 years added to SOC in 65yo+ with active RA. Results: improvement in DAS28 (0.37) but AEs occurred in 24% (infection, low bone density)—NNT 9. Study does not apply to younger pts. #ACR22 @rheumnow https://t.co/p2C6IfSje1
TheDaoIndex KDAO2011 ( View Tweet)
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GLORIA trial showing low-dose addon pred in older patients with RA showing modest benefit (including reduction in damage) balanced against increased AEs (mostly infection); NNH 9.5!
@RheumNow #ACR22 #yearinreview #ACRBest
Julian Segan JulianSegan ( View Tweet)
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Year in Review #acr22
Oral Surveillance:
With ASCVD number needed to harm 16, only 223 without ASCVD
Focus on risk stratification
@RheumNow https://t.co/tJyha1WKfR
Eric Dein ericdeinmd ( View Tweet)
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ORAL surveillance the big talking factor over the last year.
NNH of 16(!) for CV event (over 5 yrs) in those with history of atherosclerotic CV disease.
@RheumNow #ACR22 #yearinreview #ACRBest
Julian Segan JulianSegan ( View Tweet)
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Great start to year in review.
Beginning with JAKinibs in the much talked about ORAL Surveillance study.
Good Review of the mechanisms of action for JAKinibs
@RheumNow #ACR22 https://t.co/IF0t4uSefj
Robert B Chao, MD doctorRBC ( View Tweet)
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Good grief, no! Why not get a SPECT-CT and arthroscopy on them all as well? Less is more. I will grudgingly get a plain radiograph #ACR22 https://t.co/MVx5FFRsVS
Richard Conway RichardPAConway ( View Tweet)
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Abstr #0083 COVID-19 vaccine use & hesitancy among rheum pts
- 34% expressed concern for safety of primary vaccine
- 39% did not get booster due to not being told by physician
- We need to ensure pts up to date w/ vaccine including booster
https://t.co/y1vV7wbbpQ
@RheumNow #ACR22 https://t.co/gcR2yOftjq
Akhil Sood MD AkhilSoodMD ( View Tweet)
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#ACR22 Abstr#0355 It can take long time for Class V #lupus nephritis (membranous) to improve. Post-hoc analysis showed in 81 pts (31 pure class V), voclosporin reduced UPCR and faster vs MMF. Stable eGFR @RheumNow #ACRBest https://t.co/gXHxEAU5tq https://t.co/o280DnTmVj
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)