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Cancer Risk with Scleroderma

d Jack Cush, MD

Spanish Scleroderma Registry examined a large cohort of systemic sclerosis (SSc) patients showing an increased cancer risk, especially breast, lung, hematologic and colorectal cancer.

The registry included 1930 patients with SSc and were compared to a matched general population to derive the standardized incidence ratios (SIRs) and independent cancer risk factors.

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USPSTF Recommends Screening for Anxiety and Depression

d Jack Cush, MD

The U.S. Preventive Services Task Force has recommended that general practitioners actively screen and identify anxiety and depression in all adult patients under 65 yrs.

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Is PMR the Next Indication for Tocilizumab?

d MedPage Today

About half of patients with steroid-dependent polymyalgia rheumatica (PMR) were able to get off steroids altogether when they were started on tocilizumab (Actemra) infusions, which also improved disease control in most cases, a randomized phase III trial showed.

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Clinical Profiles Seen with NXP-2 Antibodies

d Jack Cush, MD

A recent review of the myositis associated autoantibody NXP-2 profiles its clinical associations with dermatomyositis (DM), calcinosis, severe myositis and, in some reports, with cancer.

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Yoga Fails to Benefit Knee Osteoarthritis

d Jack Cush, MD

The Annals of Internal Medicine has published a study showing online yoga education and an unsupervised yoga program may improve physical function did not improve knee pain after 12 weeks and 24 weeks.

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Clinical Profiles Seen with NXP-2 Antibodies A recent review of the myositis associated autoantibody NXP-2 profiles its clinical associations with dermatomyositis (DM), calcinosis, severe myositis and, in some reports, with cancer. https://t.co/DTNohe66n1 https://t.co/Bu1qbi5Q1q

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Dr. John Cush RheumNow ( View Tweet)
Yoga Fails to Benefit Knee Osteoarthritis The Annals of Internal Medicine has published a study showing online yoga education and an unsupervised yoga program may improve physical function did not improve knee pain after 12 weeks and 24 weeks. https://t.co/tmWu4t3vgX https://t.co/bJCYaCIcGE

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Dr. John Cush RheumNow ( View Tweet)
IL-6i in Behcets? Lit Review finds 25 articles papers, 74 pts (31 TNFi naive, 45 TNFi prior Rx). Pts Rx w/ tocilizumab IV. TCZ given for vascular, CNS , ocular & mucocutaneous. TCZ was effective in 87% TNF naive & 80% in TNFi Experienced pts. https://t.co/jdJ9H04lnE https://t.co/yoxrKiIVW2

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Dr. John Cush RheumNow ( View Tweet)

Are we set for the next "Twindemic"? - Continuation and evolution of COVID BA.5 to? - Flourishing Influenza in a population who has vaccine burnout? Some predicting severe flu based on Australia’s 2022 flu season, climate change, more https://t.co/qWuhWjaAFa

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Dr. John Cush RheumNow ( View Tweet)

NIH: 27 pts w/ ROSAH (retinal dystrophy, optic N. edema, splenomegaly, anhidrosis, headache) syndrome, due to dominant mutation ALPK1 - an autoinflammatory Dz w fevers, HA, Abnl CNS MRI, deforming arthritis, AA amyloidosis . https://t.co/Pyb3QNrPnB https://t.co/wxtwOGpKFr

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Dr. John Cush RheumNow ( View Tweet)
Is there link between PsA & autoinflammatory Dz? Study of 120 #PsA pts found 31% w/ AID gene variants (AP1S3, PLCG2, NOD2, NLRP12, all monoallelic variants adn 1/2 genes assoc w/ autosomal dominant disorders. https://t.co/KaL7jheDZ6 https://t.co/09CSW2W3tn

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Dr. John Cush RheumNow ( View Tweet)
Cohort Hip & Cohort Knee (CHECK) study of biomarkers (serum hs-CRP, sCOMP, sPINP sOC and urine uCTX-2) in1002 pts w/ hip or knee OA. Shows CRP, uCTX-2 & sPINP (OR 1.11-1.40) were assoc w/ nocturnal & walking pain, but not fatigue https://t.co/EOU6i24KLO https://t.co/VQWfeLR01x

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Dr. John Cush RheumNow ( View Tweet)
Hydroxychloroquine Dosing and SLE Flares JAMA cohort study examining HCQ dosing in patients with SLE suggests that HCQ doses of 5 mg/kg per day or less, was associated with a higher risk of lupus flares, including moderate or severe lupus flares. https://t.co/B5HqxWDqD3 https://t.co/4crIFBV9XP

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Dr. John Cush RheumNow ( View Tweet)
ACR's State-by-State Report Cards for Rheumatic Disease New report examines access, affordability, and activity and lifestyle factors in all 50 states and DC evaluating how easy it is to live with a rheumatic disease in your state. https://t.co/MmzG9oTfnq https://t.co/UhSM22PMf5

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Dr. John Cush RheumNow ( View Tweet)
RHEUMATOLOGISTS - How do you deal with skin Psoriasis (PSO) activity in your Psoriatic Arthritis Pts?

Dr. John Cush RheumNow ( View Tweet)

#ACR22 abstracts: 0220 Do you think social media can enhance your rheuma medical education, research or professional development? @anzypanzywanzy @anjmsantiago @PhRheumaJr @rheum4you @RHEUMarampa @RheumaRambolMD @doktora_ging #ACRambassador 📌https://t.co/SZB4p0WNu8

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Lisa 🐳🐬 rheumarhyme ( View Tweet)

New CDC data on vaccination/boosters during BA.5 wave for deaths, age 50+ https://t.co/HGyjNwUveD Compared w/unvaccinated: —92% reduction of death for 4 shots —No difference in reduction between 3 and 2 shots (~82%) [that's a 12-fold ⬇️risk of death for 4 shots in July 2022] https://t.co/3JDjCLbEyh

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Eric Topol EricTopol ( View Tweet)
IBD Ups Risk of Psoriatic Disease Findings of a new study suggest a causal effect between inflammatory bowel disease (IBD) and psoriasis (PSO) as well as psoriatic arthritis (PsA), but not vice versa. https://t.co/twam1BcG8I https://t.co/8PFObkNn4J

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Dr. John Cush RheumNow ( View Tweet)
STAR-RA study - real world claims data shows tofacitinib doesnt increase malignancy risk. Study of 83,295 pts (10,504 TOFA). Risk of malignancy w/ TOFA not increased (HR 1.01) w/ RWE or RCT-duplicate cohort (HR 1.1; 95% CI 0.85, 1.62) https://t.co/GIIvs2cK3s

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Dr. John Cush RheumNow ( View Tweet)

EMA has approved 86 biosimilar medicines since 2006 and has issued a harmonizing statement for EU countries that biosimilars are interchangeable with their reference medicine or with an equivalent biosimilar. https://t.co/ajsP1ulZTQ

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Dr. John Cush RheumNow ( View Tweet)

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