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CD19 CAR T Cell Therapy in SLE (9.16.2022)

d Jack Cush, MD

The big news this week: the approval of deucravacitinib (a new class of drug?) for psoriasis; the 2022 ACR guidance on glucocorticoid-induced osteoporosis; a national poll of older adults over the age of 50 who claimed self-reported or doctor-diagnosed arthritis; and much more. Let's review these and other news, journal reports and announcements from this past week.

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IBD Ups Risk of Psoriatic Disease

d Jack Cush, MD

Findings of a new study suggest a causal effect between inflammatory bowel disease (IBD) and psoriasis (PSO) as well as psoriatic arthritis (PsA), but not vice versa.

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Does Methotrexate Use Lead to Melanoma?

d Jack Cush, MD

A systematic review suggests that low-dose methotrexate (MTX) use is associated with an increased melanoma risk, but the absolute risk increase could be considered negligible.

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2022 New ACR Guidance on Glucocorticoid-Induced Osteoporosis (GIOP)

d ACR

The ACR has updated this guideline and includes recommendations on abaloparatide (PTHrP) and romosozumab, which are newly available since the ACR’s 2017 GIOP guideline.

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70% of Older Adults Report Joint Pain

d Jack Cush, MD

Dr. Beth Wallace and colleagues at the University of Michigan surveyed a national sample of older adults (50–80 yrs) and found that 70% currently report experiencing joint pain and 60% reported being told by a health care professional that they have arthritis. 

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Disease Activity Drives Adverse Pregnancy Outcomes in RA

d Jack Cush, MD

Two large RA registries have shown that pregnancy outcomes in rheumatoid arthritis (RA) patients is more related to RA disease activity rather than treatments use to control RA. 

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Gout Comes With Increased Heart Risk

d MedPage Today

Incidence of acute coronary syndrome (ACS) was significantly higher among gout patients than in the general Swedish population, researchers found, even when data were adjusted for common comorbidities.

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Lupus (LUMEN) registry of 440 SLE compared to non-SLE pts, shows lupus pts have less screening for cervical cancer (HR 0.75), but SLE has more screening for HTN (HR 1.35), DM (HR 2.46), hyperlipidemia (HR 3.19) & Influenza & pneumovax vaccines https://t.co/e5ZGJswVds https://t.co/WQmhM0OZgl

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Dr. John Cush RheumNow ( View Tweet)
Open label, noninferiority study TNFi withdrawal in 64 PsA & 58 axSpA pts. 2/3 tapered by dz activity T2T strategy (N=81) & 1/3 continued TNFi. At 12 mos. LDA seen in 69% w/ Tapering (~avg 53% dose) vs 73% no-tapering group (91% dose) https://t.co/K6WFaesyRt https://t.co/zqo6nVGtqW

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Dr. John Cush RheumNow ( View Tweet)
Ischemic Forearm Exercise Test - used by McArdle, notes absence of elevated blood lactate levels during exercise w/ myophosphorylase deficiency (McArdle Dz). Deficiency impairs impairs glycogen metabolism & Nl lactate production in muscle https://t.co/t4PS1ghj5d https://t.co/YUDM1GCOfn

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Dr. John Cush RheumNow ( View Tweet)
534 PsA & 470 AS pts (SERENA study) on Secukinumab for avg of ~88wks - 5.8% PsA & 8.9% AS pts had sudden stop of SEC (for avg ~25wks) (reasons? Mostly AE 58% or pt decision 10%). While TJC & SJC increased, dz control returned w/ restarting SEC https://t.co/GFxj3b06Ra https://t.co/B2ubakq8Ql

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Dr. John Cush RheumNow ( View Tweet)
2022 Univ of Michigan Natl Poll on Healthy Aging finds that 70% of older adults reported joint pain (more in Women 75% vs 65%M). 30% have a HCP dx of #OA, 8% RA, 7% gout or pseudogout & 5% w/ another kind of arthritis https://t.co/yno8RgCRQS https://t.co/yTMLHsbGOU

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Dr. John Cush RheumNow ( View Tweet)
New York is the best state for patients with #rheumatic diseases to live in, while Wyoming was ranked worst in the United States #RheumTwitter https://t.co/ulYd0uNKZO

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Healio Rheumatology HealioRheum ( View Tweet)

I just posted "Free Lupus Encyclopedia Book give away ... register to win... even international addresses are welcome" on Reddit https://t.co/Pa4h75vcW1

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Donald Thomas, MD lupuscyclopedia ( View Tweet)

New download available! COVID Deaths at 3 Mos vs. 30 Mos https://t.co/SLGJGh5NX1 https://t.co/QhWdvNHntk

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Dr. John Cush RheumNow ( View Tweet)
Provacative read from @VPrasadMDMPH on why we no longer need to or should wear masks in our clinics and hospitals (Yes, with COVID+ pts --- No, everywhere else). My advice: wear masks in high risk environments/situations. https://t.co/cECeieQ2YL https://t.co/PbX8xnfgqM

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Dr. John Cush RheumNow ( View Tweet)
The 2022 ACR abstracts are published and posted for you. Let the Learning begin! https://t.co/ZqMAc8jV3U https://t.co/3iCGnzsPI5

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Dr. John Cush RheumNow ( View Tweet)
A summary slide from #grandrounds this morning on a talk about trying to differentiate #lupus #nephritis from #preeclampsia #RheumTwitter #MedTwitter https://t.co/R2rhhgQYIm
Catherine Sims, MD DrCassySims ( View Tweet)
Mayo study of 3817 temporal artery biopsies performed on 2539 pts (1994-2004) - 681 (27%) +Bx on one side. Biopsy length HAD NO significant effect BX positivity. If 1-side initially Bx-, then Bx of the contralateral side yielded an added 7% Bx positivity https://t.co/Lr8hYHIlG7 https://t.co/alIpklPtsw

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Dr. John Cush RheumNow ( View Tweet)
Taiwan population study shows increased all-cause mortality for psoriasis patients (HR 1.16; 1.13-1.19) vs. general population. https://t.co/p09mXTfXPw https://t.co/UVK3GMMmip

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Dr. John Cush RheumNow ( View Tweet)
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