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Fever Pitch (7.15.2022)
Dr. Jack Cush reviews the new studies and drug approvals and new insights into febrile disorders from the past week on RheumNow.com
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Can Antimalarials be Withdrawn in Quiescent Lupus?
Antimalaria (AM) therapy is a cornerstone to the management of systemic lupus erythematosus (SLE), yet a recent study suggests that slowly tapering AM yields a lower rate of SLE flares.
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Still’s Disease FAQs
What is the classic 'triad' of Still's disease? Does it affect males and females equally? What are typical lab findings? Which drugs are effective at treating Still's, and as importantly, which ones are not? What about complications? Read on for these and other FAQs regarding Still's disease.
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MRP8/14 as a Biomarker in Systemic Juvenile Idiopathic Arthritis
A large cohort study of children with febrile disorders has demonstrated the diagnostic utility of Myeloid-related protein 8/14 (MRP8/14) in diagnosing systemic JIA patients (SJIA) in clinical practice.
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Immunoprofiling of synovial CD4+ T cell subsets shows that ACPA+ pts differ from ACPA- RA by having high expression of adhesion G-protein coupled receptor 56 (GPR56) on synovial CXCL13high TPH CD4+ T cells expressing LAG-3 https://t.co/LQ77CIdh9o https://t.co/chfmLfIqeF
Dr. John Cush RheumNow ( View Tweet)
Ustekinumab (IL-12/23i) phase 2 study was successful in #SLE; but the phase 3 LOTUS study of 512 pts, UST was NOT superior to PBO (SRI-4 44% v 56%) at 1 year. Study was halted for lack of efficacy (but no safety concerns). https://t.co/X5CKYVFxg5 https://t.co/6HVw6AMJPL
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Dr. John Cush RheumNow ( View Tweet)
QD Clinic - Stills (or Not) with Hives
What do you think? 40 yr. woman with fevers, hives, and LFTs.
https://t.co/IZNnWzerOL https://t.co/sUGPuy2tKC
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Dr. John Cush RheumNow ( View Tweet)
mitochondrial DNA can drive SLE by PMN uptake, NETs, activation of STING & type-I IFN. Maybe same for Autoinflammatory responses were oxidized mtDNA provokes cGAS-STING, binding cytosolic NLRP3, triggering inflammasome activity. https://t.co/sTDTkoMQX2 https://t.co/wXhVzzIFRC
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Dr. John Cush RheumNow ( View Tweet)
Steroid Injection for Chronic Achilles Tendinopathy
Adding a corticosteroid shot to exercise therapy significantly improved symptoms of chronic Achilles tendinopathy, a 100-person randomized trial found.
https://t.co/sdYmsVpBsU https://t.co/r9zFVUmE88
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Dr. John Cush RheumNow ( View Tweet)
Watch: What's new in sarcoidosis?
https://t.co/GnU1FDnUhn https://t.co/H1omKPtQmn
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Dr. John Cush RheumNow ( View Tweet)
NEJM Case - 17-Year-Old Girl with Fever and Cough and B/L lower lobe infiltrates. 3 wk hx started w/ conjunctivitis, SOB, Cough fever myalgia & knee pain. No rash. T 38.5°C, W 11.5, H/H 6.9/21, P526k, CRP 77mg/L, UA 2+ protein, neg COVID tests. https://t.co/VOiW7DIdBR https://t.co/1GWA2gAgeK
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Dr. John Cush RheumNow ( View Tweet)
1 yr success of knee arthroplasty was drawn frm 20 studies (11 317 pts, 37 factors) suggests higher BMI was correlated w/ worse physical function. Physical function & OA severity assoc. w/ better function post-TKA https://t.co/jtDCeprUhd https://t.co/Tflw8VO5Kw
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Dr. John Cush RheumNow ( View Tweet)
Metanalysis (48 pubs, 145 refract pts) of JAK inhibitors in myositis (DM, JDM) shows significant improvement in skin lesions, muscle weakness, and ILD. https://t.co/EUOB8XUCht https://t.co/SYeYwooUkW
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Dr. John Cush RheumNow ( View Tweet)
Worldwide metanalysis of FUO shows most common infections to be Mycobacterium tuberculosis (34%), brucellosis (10%), endocarditis (7.5%), abscesses (7%), herpesvirus (CMV,EBV 7%), pneumonia (6%), URI (6%), enteric fever (5%) https://t.co/RPMb1kYEI9 https://t.co/E0lrizOUkF
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Dr. John Cush RheumNow ( View Tweet)
What's going on here? https://t.co/3jwbRazJhc
Andy Tran andy23tran ( View Tweet)
When to think beyond infection in recurrent fever??Join us to learn a clear approach to fever and auto inflammatory disorders from expert faculty @bhat_chandrika at #cusp @rakshay_shetty @PedRheum @PeriodicFeverUK @LatikaGupta_ @DrPujaMehta1 https://t.co/roMVbBDaNK
RCHPediatrics RchPediatrics ( View Tweet)
@DrPujaMehta1 @leticiakawano @docrota @DrJoPorter @drharsha_gunawa @best_rheum @jeffsparks @AshimaMakol @pedrommcmachado @KaminskiMed @KerriBerriKerri @DrPeter_George @scott_matson @LatikaGupta_ What about this one https://t.co/E6oMCFlplt
Hector Chinoy drhectorchinoy ( View Tweet)
Pleased to share our review
Management of #Myositis #ILD practical guide for clinicians
#Teamwork ✍️💪
@docrota 🇺🇸 🖐️
@DrJoPorter 🫁
@drharsha_gunawa 🖐️
OpenAccess😃
https://t.co/fhCHvzXdVP
3 clinico-serological phenotypes
1⃣ anti-synthetase
2⃣ anti-MDA5
3⃣ anti-PM-Scl
/1 https://t.co/B1Qh0drSbg
Puja Mehta 🧩 DrPujaMehta1 ( View Tweet)
#idboardreview #meded #idmeded #IDtwitter #dermtwitter #MedTwitter Infectious differential diagnosis of rash involving palms & soles https://t.co/xXK4nYwEoi
Indiana University Infectious Diseases Fellowship IUIDfellowship ( View Tweet)
🆕🌟CDC Guidance on COVID-19 Vaccines for Children <18 yrs who are Immunocompromised 👦👧🏾💉⬇️
Thank you Dr. Rebecca Sadun for reviewing!
#PedsTwitter #PedsRheum #Pediatrics https://t.co/eeuRKflhSO
Mithu Maheswaranathan, MD MithuRheum ( View Tweet)