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ACR25 - Day 1 Report

Jack Cush, MD

ACR 2025 began today in Chicago with throngs of rheumatologists, fellows, ARP members, APPs and pharma folk taking to the meeting halls and rooms for tons of novel content. 

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Clinical and Genetic Effects of Neuropsychiatric Lupus

Jack Cush, MD

The clinical features and genetic abnormalities of neuropsychiatric systemic lupus erythematosus shows that NPSLE often means more severe lupus and more organ involvement beyond the central nervous system.

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Colchicine Ineffective in Long COVID

Jack Cush, MD

Management of long COVID has been perplexing with symptoms having functional and possibly inflammatory origins. Colchicine has been studied in long COVID and failed to improve functional capacity, respiratory function, or inflammatory markers. 

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Telitacicept Effective in Systemic Lupus Erythematosus

Jack Cush, MD

The NEJM has published a report from van Vollenhoven et al showing a new dual B cell inhibitor, telitacicept, to be effective when given to active systemic lupus erythematosus (SLE) patients; but this comes with a few safety concerns.

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Skin Biopsies to Predict Scleroderma Outcomes?

Jack Cush, MD

Researchers from the Hospital for Special Surgery and Weill Cornell Medicine have shown that skin biopsies in patients with systemic sclerosis (SSc) can define a fibroblast immunophenotype that may have prognostic and early treatment decision impact.

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When MAS is suspected. Soluble IL2 receptor alpha and CXCL9 may be useful (however t cell lymphomas and viral infections like hepatitis may also have them) #ACR25 @RheumNow Key takeaways below https://t.co/wJv1dvwU88

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Bella Mehta bella_mehta ( View Tweet)
Simultaneous measurements if S100, Ferritin and IL-18 increase diagnostic utility of these biomarkers in Stills disease. @RheumNow #Acr25 https://t.co/3wmijNcpVY

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Bella Mehta bella_mehta ( View Tweet)
Who talks to their neighbour? +SSA / Ro talk differently to nearby cells in #SjD #salivary #glands vs NEG Ro SjD Ro52 acts differently than Ro60 ?implications for Rx response? 🤷‍♀️ #ACR25 @RheumNow @ACRheum #Sjogren’s Abst#1684 #ACRBest! Elegant work from Sara McCoy https://t.co/UWUKAxi0UW

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Janet Pope Janetbirdope ( View Tweet)
Case series of 5 patients with binutuzumab (CD20) in AAV Short story short; it worked. Of course it worked. Obviously it worked. Everyone knew it would work. Why aren't we doing more TRIALS with new/better B cell inhibitors in AAV? #ACR25 @RheumNow Abstr#1601 https://t.co/H6Zz3Tf3xo

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Mike Putman EBRheum ( View Tweet)
Analysis from FVSG identified 36pts with anti-rituximab antibodies In AAV, lookout for this in pts who are MPO+ & w/higher CD19 at 6 mos. Worse relapse free survival in both AAV & CRYO! @TerrierBen can you share the prevalence of these abs? #ACR25 @RheumNow #ACRBest abstr#1604 https://t.co/Nyx6JxbvUk

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Mike Putman EBRheum ( View Tweet)
#ACR25 Abstr#1535 This is super-cool & watch this space! Novel Bi-specific T-cell Engager using pan-gamma delta TCR instead of currently used CD3. In vitro study = complete B-cell depletion comparable to other BiTE, but with a more favorable cytokine release profile @RheumNow https://t.co/PtR5g3gCPH

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Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
#0850 Single-cell RNA-seq of RA synovium uncovers a new biomarker & therapeutic target: PHIF Made by Tph cells, drives macrophage activation and mirrors disease severity. Big step forward in understanding RA immunopathogenesis. @RheumNow #ACR25 https://t.co/KtyxU0Lqly

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Mrinalini Dey DrMiniDey ( View Tweet)
Key slide and takeaways on the ACR 2025 extrarenal SLE guideline. Presented by Lisa Sammaritano @RheumNow #ACR25 #ACRBest https://t.co/Xa97O6RdBY

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Antoni Chan MD (Prof) synovialjoints ( View Tweet)
RA may age the immune system by nearly two decades. IgG glycome profiles showed inflammatory aging even in early RA, tied to low fitness & high inflammation. Improving muscle & fitness may help reverse this biologic clock. @RheumNow #ACR25 Abstract #0835

Jiha Lee JihaRheum ( View Tweet)

What is my risk of developing proteinuria? Hopkins Lupus Cohort developed a risk score predicting 10-year risk of new-onset proteinuria after SLE dx (n=1,418) @RheumNow #ACR25 https://t.co/Z0zPrG2NJ3

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Akhil Sood MD, MS AkhilSoodMD ( View Tweet)
#0775 Higher circulating microbial small RNA tDR-1 linked to lower risk of developing RA in CCP3+ individuals (AUC 0.86). tDR-1 downregulates interferon-response genes in vitro, suggesting microbiome-mediated anti-inflammatory mechanism in RA pathogenesis. @RheumNow #ACR25

Mrinalini Dey DrMiniDey ( View Tweet)

Telitacicept Effective in Systemic Lupus Erythematosus The NEJM has published a report from van Vollenhoven et al showing a new dual B cell inhibitor, telitacicept, to be effective when given to active systemic lupus erythematosus (SLE) patients; but this comes with a few https://t.co/lwq8ZUMTQ8
Dr. John Cush RheumNow ( View Tweet)
Review of IL-1 family cytokines in inflammation and immunity - including, IL-1, IL-18, IL-33, IL-36, IL-37, IL-38, IL-1Ra, etc. Full read -- Good Reference!! https://t.co/m2CwDydnB0 https://t.co/h90bdzv3y7

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Dr. John Cush RheumNow ( View Tweet)
Review: Monoclonal Gammopathy of Undetermined Significance NEJM has reviewed the common hematologic/immunologic finding of "monoclonal gammopathy of undetermined significance" (MGUS) - a common premalignant plasma-cell proliferative disorder found in approximately 5% of those https://t.co/kleuYayTZW
Dr. John Cush RheumNow ( View Tweet)
Sequencing DNA to find new lupus treatments MUSC geneticist Betty Tsao, Ph.D., will lead a five-year project to identify rare mutations associated with childhood-onset SLE, or lupus, with more than $3.5 million in funding from the National Institute of Arthritis and https://t.co/1vfQ4fK6FX
Dr. John Cush RheumNow ( View Tweet)
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