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Vaccination,vaccine

Flares Not Increased Following Recombinant Zoster Vaccine Injections

d Jack Cush, MD

Insurance claims analysis has shown that the use of the (CDC recommended) recombinant zoster vaccine (RZV) for prevention of herpes zoster was highly used in patients with immune-mediated inflammatory diseases and was safe, as higher rates of arthritis flares were not evident.

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covid coronavirus virus

Spondyloarthritis and COVID-19

d Robert Chao, MD

There are still questions surrounding COVID-19, and some common questions I receive from patients revolve around what to do with their current DMARDs or should they even start treatment during this pandemic. Two studies focused on this question. 

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hands pregnant

Improved Pregnancy Outcomes in SLE (2010–2020)

d Jack Cush, MD

A retrospective cohort study has shown that outcomes in pregnant systemic lupus erythematosus (SLE) patients has significantly improved in the last decade, but there still is a high risk of adverse pregnancy outcomes (APO).

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healthcare.costs_.jpg

ACR Applauds FTC Decision to Investigate PBM's

d ACR Press Release

The American College of Rheumatology applauds the Federal Trade Commission’s decision to investigate the business practices of pharmacy benefit managers (PBMs), which continue to increase PBM profit margins while placing the burden of skyrocketing drug costs on America’s most vulnerable patients,

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Smile feedback opinion yes no good back opinion

What do our lupus patients think about treat-to-target?

d Md Yuzaiful Md Yusof, MRCP(UK), PhD

In SLE, two targets that are increasingly used are the DORIS 2021 Remission and the Lupus Low Disease Activity (LLDAS). T2T is more likely to be successful if the treating clinicians and the patients set the treatment goals together. What do our patients think about T2T and do they have any say/concern?

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OA Initiative Study of 1212 knee OA pts (age 63 yrs), 73% walked for exercise. Walkers had signif. less New frequent knee pain (OR 0.6) & medial joint space narrowing (OR 0.8). Walking for exercise should be encouraged in knee OA pts. https://t.co/MLs9zutdRd

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Dr. John Cush RheumNow ( View Tweet)

Watch: Fatigue and Central Sensitization in Rheumatic Disease - We're sharing Philip Mease, MD presentation from the RheumNow Live 2022 meeting held in March. https://t.co/SFzsszL1aM https://t.co/DkxVPim9iU

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Learn how clinical research targeting immune pathways can help reduce the burden of #psoriaticarthritis symptoms, such as joint pain, stiffness, and swelling, as well as fatigue: https://t.co/ReBQVyYVka Sponsored by Janssen @JanssenUS https://t.co/fRb6kAj848

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Study of interferon (IFN) gene signature (IGS) finds IGS elevated in half of early RA pts; high IGS portends higher DAS28, fewer EULAR good resp & higher IFN-α; the latter assoc w/ epigentic changes, more lymphoctye activation. IFN-α as a biomarker? https://t.co/BHC98OR30A https://t.co/SRE7KVaoha

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Dr. John Cush RheumNow ( View Tweet)
Yesterday the FDA approved baricitinib (Olumiant) as the first systemic treatment for Alopecia Areata. Approval based on 2 DBRPCT Trial AA-1, AA-2) - 32% & 35% of pts on Bari 4 mg regrew scalp hair coverage by wk 36. https://t.co/SU74OxI2BC https://t.co/2wluug1fj4

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Dr. John Cush RheumNow ( View Tweet)
450 axSpA pts followed 2868 Pt-yrs, 48% on TNFis. TNFi Rx pts had reduced CV risk (HR 0.30; 0.10–0.85), but no longer signif after adjustment for CRP, ESR (HR 0.37, 0.12–1.12, p = 0.077). Reduced CV risk, may not be specifically due to TNFi use https://t.co/mVHYn3PteL https://t.co/bgKWreBL8z

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JAKi not yet safe in pregnancy - theyre fetotoxic at high doses (animals). JAKi do cross placenta. ACR Guidelines: no position due to no data. 47 tofa Rheum & 15 UC maternal exposures - no signif probs. Paternal use of JAKi is ok. https://t.co/pom5KD0qt7 https://t.co/djYHZ5LdcE https://t.co/47lfyZC4H3

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Dr. John Cush RheumNow ( View Tweet)
Watch: The Microbiome in Spondyloarthritis Can microbes trigger SpA/PsA? https://t.co/KN7dMFU9qo https://t.co/k3M5QfwqGp

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Cluster study of 383 aPL+ pts showed 4 clusters: Cluster 1 (138): w/ SLE & non-criteria Sxs Cluster 2 (112): pts w/ CV risks Cluster 3 (83): females w/ OB morbidity (BEST outcome) Cluster 4 (50): lupus anticoagulant (+) (high freq of arterial thrombosis) https://t.co/HGRTceplsn https://t.co/ZDdwhCmj5r

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Dr. John Cush RheumNow ( View Tweet)
GLORIA Study Pred vs PBO in >65yrs RA x 2 years. 451 Pts & DAS28 4.5. 79% on DMARDs (14% biologics) Upside: Lower DAS28 -0.37 & less Xray progression -1.7 Sharp units Downside: 24% more AE (mild infxns), signif.small lowering of lumbar BMD -1% You Decide https://t.co/RRq0WcFsXz https://t.co/xLxjPPSMhh

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Dr. John Cush RheumNow ( View Tweet)
MMWR: Monkeypox Outbreak in Nine States CDC is tracking multiple reported U.S. monkeypox cases, and monitoring cases in persons in countries without endemic monkeypox and with no known travel links to an endemic area. https://t.co/Pr0n7pwAgS https://t.co/DvJtLq85E2

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CV risk factors not equal when considering magnitude of risk What can we learn from Oral Surveillance? The Oral Surveillance trial has almost become a household word for rheumatologists. https://t.co/LHZTVZh4AK https://t.co/2SlxrG7UpQ

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Dr. John Cush RheumNow ( View Tweet)
Watch: #EULAR2022 - Day 4 Faculty Panel Recap Dr. David Liew and Dr. Jack Cush discuss day 4 of EULAR 2022. LB0001, LB0002, LB0004, and LB0006. https://t.co/HomsEG9CdX https://t.co/LdMa2FUe76

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Dr. John Cush RheumNow ( View Tweet)
WATCH: #EULAR2022 - Day 3 Faculty Panel Recap Drs. Jack Cush, Janet Pope, Aurelie Najm and Yuz Yusof discuss highlights from Day 3 of EULAR 2022. https://t.co/6Xdu3acGXN @Janetbirdope @AurelieRheumo @Yuz6Yusof https://t.co/juFkMtF5hS

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Dr. John Cush RheumNow ( View Tweet)
#EULAR2022 - Day 2 Faculty Recap Panel Dr. Jack Cush, Dr. Robert Chao and Dr. Richard Conway discuss interesting abstracts and seminars from day 2 at EULAR 2022. https://t.co/aTVKYhggGD @doctorRBC @RichardPAConway https://t.co/kn3PkaFGSy

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Dr. John Cush RheumNow ( View Tweet)

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