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Does MTX have an impact on UST-immunogenicity in PsA?
Post-hoc analysis from UST RCT in 110+ pts
No difference in ADA rates & concentrations between
MTX and non-MTX groups and
ADA not associated w/ decreased UST levels
POS0079 @RheumNow #EULAR2022 https://t.co/TA0YTx8qRT
Aurelie Najm AurelieRheumo ( View Tweet)
Don’t forget about the benefits of vaccines for diseases other than #COVID19 – Dr. K Hyrich #EULAR2022 @rheumnow https://t.co/86e93ugoBQ
TheDaoIndex KDAO2011 ( View Tweet)
Pneumonia and influenza risk higher in patients with rheumatic disease!
Influenza Relative Risk: 1.2-3.3
Pneumonia RR: shown to be up to 14.2 in SLE!
💉Vaccinations work!
#EULAR2022 @Rheumnow @rheum_covid https://t.co/gvD1PaLQRe
Eric Dein ericdeinmd ( View Tweet)
Sanchez-Martin et al. Tocilizumab in newly diagnosed vs refractory GCA. 471 patients. Appears of relatively similar efficacy in both groups. Surprising that the difference is not greater given refractory GCA inherently more complex @RheumNow #EULAR2022 POS0817 https://t.co/HEWzYCz9YD
Richard Conway RichardPAConway ( View Tweet)
Proof that vaccines work in our rheum patients; reduction in hospitalization, ICUs, death – Dr. K Hyrich #EULAR2022 @rheumnow https://t.co/u8PWvgfdiC
TheDaoIndex KDAO2011 ( View Tweet)
#EULAR2022:
Kimme Hyrich: Think about Herpes zoster risk in ALL rheumatic disease patients (not just, but particularly with JAKs).
💉Avoid Zostavax (Live) in patients on immunosuppression
💉Warn side effects are common with Shingrix
@RheumNow @rheum_covid https://t.co/w7p4oHuqL9
Eric Dein ericdeinmd ( View Tweet)
2 year guselkumab data from Discover-2 @DrLauraCoates et al. Continue incremental improvements across all key domains through 2 years of treatment @RheumNow #EULAR2022 POS1017 https://t.co/wcSKCID9Yt
Richard Conway RichardPAConway ( View Tweet)
☄️ Biomarkers substudies of COSMOS & DISCOVER-1 RCT GUS in PsA:
TNFi-IR pts have a different plasma signature w/ higher BL IL-22 & TNF
*Association between BL IL-22 levels & W24 PASI75
and trend for BL IL-22 levels & W24 ACR20
#EULAR2022 @RheumNow POS0074 @StefanSiebert1 https://t.co/Midtug4NJO
Aurelie Najm AurelieRheumo ( View Tweet)
Dr. K Hyrich who/when to vaccinate. #EULAR2022 @rheumnow https://t.co/40y9ngJnbW
TheDaoIndex KDAO2011 ( View Tweet)
#Vaccine disparities globally #EULAR2022 @rheumnow https://t.co/w12ok1Y1b5
TheDaoIndex KDAO2011 ( View Tweet)
Kimme Hydrich: There is no increased of "exceedingly rare" vaccination adverse effects in rheumatic patients
💉APLS is NOT a risk factor for thrombotic AEs with vaccination
#EULAR2022 @Rheumnow @rheum_covid
Eric Dein ericdeinmd ( View Tweet)
HAS-GCA study @alwinuk @profbdasgupta Southend pretest probability score and Halo score useful in diagnosis and prognosis in GCA. Halo score may be useful for monitoring. @RheumNow #EULAR2022 POS0818 https://t.co/sxYjnQQFA8
Richard Conway RichardPAConway ( View Tweet)
Do you vaccine pts w/ RMDs for shingles?
If so, when and who and with what?
@khyrich highlights differences in recommendations and contra-indications across countries
#EULAR2022 @RheumNow https://t.co/c0uvOPopF4
Aurelie Najm AurelieRheumo ( View Tweet)
“One of the benefits of #vaccinations people don’t talk about is the relief they feel after vaccination."
- Dr E Hyrich #EULAR2022 @rheumnow
TheDaoIndex KDAO2011 ( View Tweet)
RheumNow’s coverage of the #EULAR2022 Annual meeting is sponsored in part by Bristol-Myers Squibb. All content is chosen by RheumNow & its Faculty.
Dr. John Cush RheumNow ( View Tweet)
💫Trajectory analysis in SpA💫
Data on 1,125 patients
Prediction of spinal radiographic progression
⭐️FAST associated w/ onset at older age & 👁involvement
⭐️SLOW progression associated w/ female gender & peripheral involvement.
#EULAR2022 @RheumNow OP0151 https://t.co/E80qCLEtBv
Aurelie Najm AurelieRheumo ( View Tweet)
Preito-Pena at al. Tocilizumab in LVV-GCA and TAK. Similar responses in both, with 75% showing complete clinical response but only 20% complete imaging response at month 12. Clinical implications of these persistent imaging findings need clarification @RheumNow #EULAR2022 POS0804 https://t.co/sNbRzIkwnt
Richard Conway RichardPAConway ( View Tweet)
#EULAR2022
"The mRNA vaccines are simple to make." - Saul Faust
The key step is encapsulation in lipid to allow for take up by cell.
💉💉💉
@RheumNow https://t.co/T2ZxF6bLV5
Eric Dein ericdeinmd ( View Tweet)
Comorbidity in AS from @rheum_cat , Karmacharya et al. Clustering of comorbidities. Depression and hypertension clusters assoc worse disease activity and function @RheumNow #EULAR2022 OP0154 https://t.co/jGQXayAYs9 https://t.co/SnVDhVYQq5
Links:
Richard Conway RichardPAConway ( View Tweet)
Flatman et al. Serious infections in babies born to women using TNFi during pregnancy. 2902 babies. Adjusted HR 1.20 (0.54-2.64) for agents with high vs low placental transfer. @RheumNow #EULAR2022 OP0130 https://t.co/oaW7wDPxva
Links:
Richard Conway RichardPAConway ( View Tweet)