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SLE, Sex and STDs
Once in a while, I find an abstract at the ACR meeting that can potentially save lives and be implemented in practice now.
In Abstract #0939, Dr. J Patricia Dhar and colleagues shared data from a pilot study examining a new method to monitor cervical health in African American Women with Systemic Lupus Erythematosus (SLE) using a self-sampling brush to assess cervical cytology and human papilloma virus infection.
TNFi cycling in axSpA: Results from CorEVITAS Registy study
Data presented at ACR22 shows that cycling through TNFi in axSpA patients with primary lack of efficacy with first line TNFi has limited additional benefit in controlling disease.
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Boekel et al. Omicron variant assoc lower risk of severe COVID-19 in rheumatic disease than prior variants EXCEPT rituximab treated patients. @RheumNow #ACR22 Abstr#0705 https://t.co/57Boj4SEt5 https://t.co/d2NoX83y5l
Richard Conway RichardPAConway ( View Tweet)
Mendel et al. Use of TMP-SMX prophylaxis in GPA from MarketScan and Medicaid. Used in <25% treated with RTX!? Female sex negatively assoc (OR 0.61)!? Steroid use in month prior associated (OR 4.31) @RheumNow #ACR22 Abstr#1071 https://t.co/56a0nHR8o4 https://t.co/5LygdFMrss
Richard Conway RichardPAConway ( View Tweet)
Kifayat et al. Response to Shingrix in rheumatic disease patients. 3/3 PsA, 5/6 SLE, 2/14 RA pts reached protective level of 150U/ml. IgG titres and SI are 3x lower compared to non-rheumatic patients. @RheumNow #ACR22 Abstr#0800 https://t.co/Gm7ldxK5xd https://t.co/BlHuU2Jxk2
Richard Conway RichardPAConway ( View Tweet)
I was schooled for exams, testing fine motor function with a buttonhole: felt contrived.
Imagine an electrical glove for RA pts, doing functional assessment properly
Italian study: engineered glove data + HAQ correlates with DAS28
Consistent/scalable!
ABST0904 #ACR22 @RheumNow https://t.co/4ZR0An5N9j
David Liew drdavidliew ( View Tweet)
Martínez-López et al. Higher rates of elevated transaminases with DMARD in those who previously had abnormal transaminases with isoniazid. @RheumNow #ACR22 Abstr#0816 https://t.co/xiL6DPPcw3 https://t.co/jjxRoEr8iM
Richard Conway RichardPAConway ( View Tweet)
Khidir et al. Lower educational level increases risk of progression of clinical suspect arthralgia to inflammatory arthritis. HR 2.35 and 5.72 in 2 cohorts. not explained by smoking, BMI or a delay in seeking medical care @RheumNow #ACR22 Abstr#0704 https://t.co/B4bm2Ihapx https://t.co/Veks0WpHLR
Richard Conway RichardPAConway ( View Tweet)
Ab1042 #ACR22 Ixekizumab Long-term Safety
A Deodhar: Pooled 25 studies for PsO, PsA, AS
5.4 pooled AE per 100-patient/year
0.5 IBD per 100-PY
1.3 Oral candidiasis per 100-PY
Re-assuring safety numbers. Deodhar: "These are numbers to use in clinical practice"
@RheumNow
Eric Dein ericdeinmd ( View Tweet)
Hamroun et al. Unfavourable pregnancy outcomes associated age, nulliparity, steroids in RA. Can only modulate the final one! @RheumNow #ACR22 Abstr#0955 https://t.co/Vob1GeMN25 https://t.co/CsVshIzp8a
Richard Conway RichardPAConway ( View Tweet)
de Hooge & al: parameters assoc w/ risk of developing syndesmophytes at 2 yrs in PsA:
Radiographic SI according to mNY = 30x higher risk
If Rx SI + CRP>6 = 100% risk devlpmt syndesmophytes @ 2 yrs.
https://t.co/CR0LymrQdr
Abs#1014 #ACR22 @Rheumnow
#ACRBest https://t.co/TLWYCJ0eYi
Aurelie Najm AurelieRheumo ( View Tweet)
Rouhi @Janetbirdope et al RS3PE post checkpoint inhibitor. 11 cases. Can flare after checkpoint inhibitor reintroduction and occur following treatment. @RheumNow #ACR22 Abstr#0758 https://t.co/KCzdJvD0da https://t.co/WQ4eB2hz1k
Richard Conway RichardPAConway ( View Tweet)
Giblo et al, 1000+ pop-based cohort RA:
Cumulative incidence of depression =
Increase in cumulative incidence of anxiety 2005–14 vs. earlier decades
Despite improvements in RA ttmts. Maybe time we address these separately?
https://t.co/Z3FUgSETKW
Abs#0889 #ACR22 @Rheumnow https://t.co/Rn2ru80021
Aurelie Najm AurelieRheumo ( View Tweet)
Kang @karen_kc123 et al ≥ 20 pack-years cigarette smoking associated with higher risk of incident PMR in women (HR 1.46). Every 10 pack-years associated 9% increase in risk @RheumNow #ACR22 Abstr#0698 https://t.co/t51fKFs7iJ https://t.co/IS9XC9DXl8
Richard Conway RichardPAConway ( View Tweet)
Maguire @Sineadm15 @rheum_covid (and me!) obstetric outcomes in RMD and COVID-19. Unvaccinated higher freq pre-term birth. Regardless of vaccine status, the women themselves did well, rarely needing pharmacotherapy @RheumNow #ACR22 Abstr#0950 #ACRbest https://t.co/GLMAAvbC4a https://t.co/kpXZbRSoMo
Richard Conway RichardPAConway ( View Tweet)
DIPSA: RCT in PsA pts w/ BMI > 25 Mediterranean diet vs. DASH-low caloric diet vs. SoC
BL: 72% obese, 42% dyslipidemia, 38% HBP, MetS 47%
Looking forward to seeing the results of this dietary intervention, MetS is high in PsA!
https://t.co/29Aq0TLANO
Abs#1007 #ACR22 @Rheumnow https://t.co/MoVYnQV6xR
Aurelie Najm AurelieRheumo ( View Tweet)
Ab0411 #ACR22 Bimekizumab in AS
P3 24 wk PBO control study BE-MOBILE 2
221 BKZ, 111 PBO
Wk 16 ASAS40: BKZ 45%, 22% PBO p<0.001
Efficacy in both TNF naive and TNF failure pts
Wk 24: 1/2 pts has ASDAS<2.1
Nasopharyngitis (6%), diarrhea (4%), h/a (3.6%) 👅candidiasis (3%)
@Rheumnow https://t.co/R1ieW0FB6m
Eric Dein ericdeinmd ( View Tweet)
Mathew et al. Combination biologics from MarketScan. Combination less likely to have ER visit in 180 days 17% vs 23% @RheumNow #ACR22 Abstr#0768 https://t.co/Y880qDXMow https://t.co/gOH2Zlt6UV
Richard Conway RichardPAConway ( View Tweet)
CASIPSA study: retro CT SIJ analysis 48 PsA & age/sex matched ctrls.
JSN, erosion, sclerosis in 1/3 pts w/ peripheral & 1/3 pts w/ axial disease.
PsA > erosions, no diff in other parameters: lack of power or true absence of diff?
https://t.co/CR0LymrinT
Abs#1012 #ACR22 @Rheumnow https://t.co/akYYqbIFNx
Aurelie Najm AurelieRheumo ( View Tweet)
Wang @zach_wallace_md et al. Machine learning can accurately classify clinical note sections as reflecting a diagnosis of AAV. As a machine learning sceptic, data like this helps (slowly) convert me. @RheumNow #ACR22 Abstr#0700 https://t.co/qbq9j9XzXG https://t.co/8iNJElI2vJ
Richard Conway RichardPAConway ( View Tweet)
