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JAK Inhibitor Potential in Systemic Sclerosis-Associated ILD

d Jack Cush, MD

The occurrence of interstitial lung disease (ILD) in Systemic sclerosis portends serious morbid and mortal outcomes for those affected. This review examines the available clinical literature on the potential benefits and outcomes of JAK inhibitor use in SSc=ILD.

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Vegetarian diet food nutrition

ACR New Guidelines on Integrative Approach to RA

d ACR

The American College of Rheumatology (ACR) released a summary of its new guideline for Exercise, Rehabilitation, Diet and Additional Integrative Interventions for Rheumatoid Arthritis.

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lupus SLE

CXCL5 Therapy in Lupus?

d EurekAlert!

 A new study has shown that restoring the balance of a protein in blood may be a promising treatment option for systemic lupus erythematosus.

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Marginal Benefit with Diet and Exercise in Obese Knee Osteoarthritis Patients

d Jack Cush, MD

The easiest intervention for knee osteoarthritis (diet and exercise) is also the most difficult for many patients; but do these work? A new study of a weight loss and exercise program in community settings shows only marginal benefits. 

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Efgartigimod Treatment in Chronic Primary ITP

d EurekAlert!

Patients taking efgartigimod, a drug being studied for use to treat chronic primary immune thrombocytopenia (ITP), exhibited a significantly greater improvement in platelet counts which are essential to clotting and stopping bleeding, compared to those taking a placebo, according to results repor

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Comorbidities in Axial Spondyloarthritis Dr. Antoni Chan discusses Abstract 1609 at ACR22 Convergence. https://t.co/dCLlgiGV9K https://t.co/a4iI1q3zZC

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Will a vegetarian diet and exercise actually help RA disease activity? https://t.co/NI6xmhN0sO https://t.co/7IlQWkXkE1

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A&R: Climate Emergency and the Health of Our Patients - A public health crisis that will affect Rheum pts - climate factors can worsen Dz - Pollution causes autoimmunity - Climates worse effects on the vulnerable - Advocacy solutions research are needed https://t.co/JJufiImhND

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Efgartigimod Treatment in Chronic Primary ITP https://t.co/iJMeG2CJJv https://t.co/OXE7CuScBC

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Substandard Therapy in RA Clinicians could improve outcomes in their patients w/ RA by paying attention to certain markers of care quality, like early referral to certified rheumatologists and prescribing standard drugs for RA, new research suggested. https://t.co/Ln6XQHLVJE https://t.co/454Ff8dEr8

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Practical Guidance for the Clinical Rheumatologist in Unplanned Pregnancies Women of reproductive age comprise an overwhelming majority of patients with rheumatic and musculoskeletal disease. https://t.co/45ABQ0e2Qy https://t.co/dhLqzjf9uL

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NIH has granted $4.7 million to fund OHSU/UAB/UNC scientists to develop Novel 2-Pyrimidone (SRI-42718) Chikungunya antiviral drug. 2022: >360,000 Chikungunya cases w/ 77 deaths (mostly Brazil, India Guatemala) w/ 13 acquired in U.S. https://t.co/5ospHoFBBQ https://t.co/E1WKvdhaUO

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Swedish study of 4033 incident RA vs 6485 controls - Exposure to occupational inhalable increased risk ACPA+ RA (OR 1.25). Occupational inhalable agents plus smoking and shared epitope markedly elevated risk (OR 18.22) esp in ACPA+RA https://t.co/4lKLEhkURm https://t.co/HFhz8lMR10

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Study of 172 febrile pts w skin rash + arthralgia; 112 Dx w/ #AOSD. Use of a "streamlined diagnostic process (looking @ neutrophilia, hyperferritinemia, high IL-18), shortened Dx time (2 vs 4 wks), earlier Dx and more remissions (85% vs 68%, p < 0.05) https://t.co/MSMq2XLeYA https://t.co/ECKkeVqTIW

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Biosimilar Bonanza in 2023 Dr. Jack Cush reviews more than a dozen news and journal articles from this past week on RheumNow https://t.co/FILyCcSThn https://t.co/kBxzZgs6rM

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2022 ACR/EULAR Giant Cell Arteritis Classification Criteria Giant cell arteritis (GCA) has historically been a clinical diagnosis (visual loss, headache, jaw pain, scalp tenderness, etc) supported by labs and histopathology. https://t.co/inHKcdXLmD https://t.co/g9v1zWkmRp

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Small, open label study of 43 RA pts Rx w/ csDMARDs randomized to denosumab or PBO x 24 weeks. Erosions of MCP 2,3 assessed by HR-pQCT shows no significant differences in erosions or safety signals at 6 mos between groups. https://t.co/AuysVPFD4S https://t.co/yQ4R41hSMi

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FROST study (First-line options sJIA Tx) - a prospective study to assess treatments in SJIA. 86% Rx w/ biologic (IL-1/IL-6 i) & 14% non-biologic Rx. oral GC used in 54% biologic & 90% of non-biologic. 1/2 non-biologic went onto biologics w/in 4 mos. https://t.co/8TMpEPgzOr https://t.co/N8laSs5rrZ

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The Best Prescription The craziest question that you can ask any doctor is “what is your best therapy for __?”. Crazy, because there are exponential answers, with factored layers that make each decision unique to that doctor. https://t.co/iX8T6NSD00 https://t.co/8VUPbDjXzr

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73-87% of autoimmune (RA, SLE, UCTD, APL) pts used HCQ during pregnancy. HCQ significantly reduced pre-eclampsia (20% vs 9%), early-onset pre-eclampsia (8% vs 2.5%), 2nd/3rd trimester pregnancy loss (3% vs. 0.6%) https://t.co/KrA3XtGNmK https://t.co/HwpmipgJYC

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