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Biologics for JIA? Not So Fast, Say Insurers

d MedPage Today

It's not a simple matter to prescribe tumor necrosis factor (TNF) inhibitors for patients with juvenile idiopathic arthritis (JIA), at least those with insurance, a single-center study found.

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Arthritis Predicts Hepatic Fibrosis in Hemochromatosis

d Jack Cush, MD

Mayo Clinic Proceedings reports the results of a retrospective, cross-sectional of patients with HFE hemochromatosis showing that advanced hepatic fibrosis is primarily seen in those with arthritis due to HFE hemochromatosis. 

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Pre-exposure Prophylaxis for COVID-19 (4.22.22)

d Jack Cush, MD

Dr. Jack Cush discusses the news and recent journal reports from last weeks RheumNow.com, and answers viewer questions from #ACA - Ask Cush Anything.

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SLE (n=2428) pts followed for 224,295 Pt-months- Osteonecrosis seen in 122 pts (6.5/1,000 PtYrs). Higher ON risk - African Americans (2x), Male (1.8x), smokers (1.5x). Higher Rates w/ high dose prednisone (not pulse or IM TCA) https://t.co/omU9Z1Z3kU https://t.co/wceGoCcUBV

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Systematic literature review of studies where steroids were used as initial "Bridge Therapy" in RA patients - included 10 studies, but only 4 RCTs w/ protocolized discontinuation - these showed 22% were still on GC @ 12 mos, 10% @24 mos https://t.co/aRLhptAASe https://t.co/lg4msIyQfc

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Watch: Dr. Ritchlin discusses Future Discovery and Targets. https://t.co/MOQjXWd6tc https://t.co/EQWBnL9jzI

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Spanish BIOBADASER registry real world performance of secukinumab in 639 pts w/ #PsA & spondyloarthritis (axSpA, AS, NR axSpA) showed imprved Dz activity at 1 yr & maintained or increased 2 & 3 years. Retention rates best when SEC used 1st biologic https://t.co/MAE3BhLlRg

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Cardiovascular risk (CVR) was assessed in Psoriasis (#PSO) & #PSA in multiracial population in S Brazil using the Framingham Risk Score. Compared to controls PSO & PSA had higher FRS (16.3 & 18 vs 10.6) and also increased with age. highttps://bit.ly/3k7ySi8

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FDA approved 1st drug for kids with COVID-19. Veklury (remdesivir) get an expanded indication in Peds >28days old & wt > 3 kg who has SARS-CoV-2 & are Hospitalized, or Not hospitalized & at high risk for severe COVID-19 or death https://t.co/7Hn4CwKjxv

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COVID-19 Vaccination Uptake and Perceptions in Rheumatic Patients Putman et al has reported vaccine survey results from the C19-GRA in Lancet Rheumatology showing the uptake and vaccine hesitancy among people with rheumatic diseases (RMD). https://t.co/sqsOHGThzV https://t.co/zeZrlDeQ9Z

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One centers experience with a combined Rheum-Derm Clinic. Among 151 psoriasis patients with suspicious musculoskeletal complaints, 85% were dx w/ PsA - 62% of these PsA was 1st diagnosed. https://t.co/RcQrWaXTWj

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QD Clinic - PsA lessons and cases from the Rheumatology clinic. Distinguishing Psoriatic arthritis from Erosive Osteoarthritis can be difficult https://t.co/UCcCMqUL2d https://t.co/zLkfBYI4Cm

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Open label, RCT compared triple DMARD Rx adding either LEF (MLH) or SSZ (MSH) to MTX+HCQ in 136 RA pts. Both were equally effective (non-inferior), 61.7% & 64.7% patients (p = 0.8) at wk 24. AE were also equal (15 vs 21 AE). https://t.co/ZucrYKuNms

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Mark your calendars for our next Tuesday Night Rheumatology on 4/26 at 7pm! Speakers will include: Dr. Eric Ruderman Dr. Arthur Kavanaugh Dr. David Liew Dr. Jack Cush https://t.co/by1xtmPSZ0 You can also find us LIVE on YouTube, Twitter, and Facebook. https://t.co/o633KHx81b

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ICYMI:Faith in Exercise Benefit Boosts Actual Benefit in SpA https://t.co/kEErN5IZUI https://t.co/9ve0ey9MRp

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Global Rheumatology Therapeutics (drug) Market size is estimated to be $29.37 billion (USD) in 2022, and is projected to grow to $40.13 billion by 2027. https://t.co/JDzkYFENFc

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ICYMI: Axial Disease in Psoriatic Arthritis Inflammatory involvement of the axial skeleton and sacroiliac joints occurs, on average, in 40-50% of patients with psoriatic arthritis (PsA). https://t.co/QKtpSPDz5V https://t.co/ROz5o9OTyZ

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QD clinic - PsA Lessons from Patients Enthesitis in a 14 yr.old - management and evolutionary possibilities https://t.co/MtgoDXJ7EF https://t.co/sTFyySF4vl

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Did you missed this past Tuesday Night Rheumatology? We have the playback available now. The PsA Expert panelists included: Dr. Dafna Gladman Dr. Joseph Merola, Dr. Peter Nash, Dr. Christopher Ritchlin, Dr. Jose Scher and Dr. Jack Cush. https://t.co/u5lt2uDoGK https://t.co/lOmN4OoGLi

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COVID-19 Vaccination Uptake and Perceptions in Rheumatic Patients Putman et al has reported vaccine survey results from the C19-GRA in Lancet Rheumatology showing the uptake and vaccine hesitancy among people with rheumatic diseases (RMD). https://t.co/fIHAhpvVho https://t.co/6tFbQd0vJQ

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