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Autoimmune disease and pregnancy
EurekAlert!
For many aspiring mothers with autoimmune disease, pregnancy can be daunting and full of unknowns. In some cases, those suffering from specific autoimmune conditions have chosen to forego pregnancy altogether due to concerns about their disease treatments and adverse pregnancy outcomes.
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SeXXist Reason for More Women with Autoimmune Disease
EurekAlert!
Somewhere between 24 and 50 million Americans have an autoimmune disease, a condition in which the immune system attacks our own tissues. As many as 4 out of 5 of those people are women.
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85 Chinese SLE pts study of Dz activity & depression/ anxiety assessed by PHQ-9 & GAD-7. Good correlation betw SLEDAI-2K & SLE-DAS (r=0.76);also w/ mod-high activity (r=0.79), but less w/ mild Dz/remission (r=0.45). Anxiety/Depresion did not affect scores https://t.co/eyhgiYxf3P https://t.co/5LHg3HO21v
Dr. John Cush RheumNow ( View Tweet)
Full read overview of SJOGRENS SYNDROME, which can be Primary SS or Secondary (15% in SLE, 20% RA, & 30% systemic sclerosis). SS Organ involvement:
- CNS 2-17%
- Renal <=10%
- ILD 10-20%
-MSK 45-56%
https://t.co/RElOFfP2xr https://t.co/aJI041VCuE
Dr. John Cush RheumNow ( View Tweet)
Danish registries study shows maternal Autoimmune Dzs (all) were assoc w/ incr risk of childhood cancers (OR=1.25, 95% CI 1.06, 1.47), acute lymphoblastic leukemia (OR =1.52), Burkitt lymphoma (OR=2.6) & CNS tumors (OR=1.45); same seen for RA mothers https://t.co/HQO972ch9R https://t.co/dDEJUo8unq
Dr. John Cush RheumNow ( View Tweet)
Microbiome study of 16 SLE pts (44 fecal samples) shows that blooms of Ruminococcus gnavus pathobiont was assoc w/ lupus flares and may be the drivers of clinical of relapsing lupus disease https://t.co/Sj3dLesZpL https://t.co/7cu0X7jPM9
Dr. John Cush RheumNow ( View Tweet)
FDA Safety Warning: denosumab now has a Boxed Warning for risk of severe hypocalcemia in CKD pts taking Prolia (usually seen 2-10 wks post injx). Pts may or may not be symptomatic. CKD pts should have Ca and Creatinine monitored. https://t.co/UMYxjWz9n4 https://t.co/AG5wzBrY1Y
Dr. John Cush RheumNow ( View Tweet)
The ultimate treatment goal in LN is long term preservation of kidney function.
Summary of part 3 of @andreafava brilliant talk.
#RNL2024
@RheumNow https://t.co/vwiAbWEmRh
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Very insightful talk on Vasculitis and pregnancy by Catherine Sims.
Pregnancy compatible medications.
Remission state.
Checking antibodies ; risk of transmission, pregnancy and fetal morbidity.
#RNL2024
@RheumNow https://t.co/81NAN1ulO5
Links:
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Urine biomarkers ( IL-16, CD163,CD206), parallel internal activity in lupus nephritis and and its decline at 3 months , best predict 1 year response .
Future is great for lupus nephritis , cant wait to start using them.
Great work @andreafava
#RNL2024
@RheumNow https://t.co/VIFMytHFyD
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Urine proteomics in lupus nephritis.
Summary of part one of his amazing talk.
@andreafava
#RNL2024
@RheumNow https://t.co/h8Eda0ZWVE
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Neutrophil signature in proliferative lupus nephritis.
@andreafava
#RNL2024
@RheumNow https://t.co/tNFIhohSvP
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
2nd kidney biopsy in lupus nephritis have value. @andreafava
#RNL2024
@RheumNow https://t.co/47J1CGQL81
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Proteinuria doesn’t correlate with internal activity in lupus nephritis , we really need better biomarkers.
@andreafava
#RNL2024
@RheumNow https://t.co/bFuxVnUCEB
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Dr. Gabalawy: "How do you know what disease patients will develop in this preclinical autoimmunity state?"
@drdavidkarp "it's like when weeds pop up in a garden, it's random ...if ACPA Ab pops up, you might have RA, if it's dsDNA, maybe lupus." #RNL2024 @RheumNow https://t.co/JmDtaTt3sU
TheDaoIndex KDAO2011 ( View Tweet)
Great talk -this is a summary slide on lupus nephritis and biomarkers to predict renal survival. When you get a chance, you have to watch @andreafava on #RNL2024 https://t.co/3PgFWCU9n6 @RheumNow https://t.co/AZNq9XrTMx
TheDaoIndex KDAO2011 ( View Tweet)
Low urine IL-16 at 12 months predicted kidney survival much better than proteinuria. Check out AUCs in the this first slide. Dr. @andreafava reviews this potential biomarker. Question if this could also be a possible target for treatment as well?
#RNL2024 @RheumNow https://t.co/cCLRERVXmq
Links:
Dr. Rachel Tate uptoTate ( View Tweet)
Low urinary IL16 levels at 12 months predicts kidney suvial at 3 years better than proteinuria - @Andreafava @rheumnow #RNL2024 https://t.co/AEaL8n2nv8
TheDaoIndex KDAO2011 ( View Tweet)
@andreafava @jhrheumatology
Urinary biomarkers (CD163, IL-16) at 3 months predict the 1 year response better than UPCR
- At 6 & 12 mos predicts renal survival at 3 yrs
- At 12 mos: IL-16 92% accurate, sens 97%, Spec 80% vs UPCR 72% accurate, 75% sens, spec 67%
#ACR2024 @RheumNow https://t.co/YtbCrwrch0
Links:
Eric Dein ericdeinmd ( View Tweet)
Scary! A third of patient with lupus nephritis who are considered complete respondues continue to aaccrue progressive renal damage - @Andreafava @rheumnow #RNL2024 https://t.co/mhu3YoY3YV
TheDaoIndex KDAO2011 ( View Tweet)
