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Does the weather affect synovitis? Abstract this suggested so! Low wind speed & temp rise associated w/joint u/s findings in a large prospectove cohort Full disclosure: I'm super skeptical of this, whole lotta p values. Still, love "fun" science😂🤣 @RheumNow #ACR23 Abstr407 https://t.co/JkqdUbM8YK
Mike Putman EBRheum ( View Tweet)
Pregnancy is complicated for women with rheumatic diseases. There's a pathway to healthy mothers & babies, but it takes: - planning - the right meds - the right disease control. @drbags71 #ACR23 Review Course @RheumNow https://t.co/epdDIVGPye
David Liew drdavidliew ( View Tweet)
Habitually Noncompliant Seronegative RA - No Show, Won't Go, prn Patient QD Clinics are sponsored by RheumNows Coverage of #ACR23 live from San Diego https://t.co/jeD3H9RHvs https://t.co/zIEkecPEu0

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Dr. John Cush RheumNow ( View Tweet)
AI Can Predicts Radiographic Change in RA The ACR has published a preview of new research from #ACR23 showing that AI & a deep learning system could accurately identify & predict joint space narrowing and erosions in hand radiographs of patients w/ RA. https://t.co/GGplIcyZLk https://t.co/CVhZfR4gCj

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Dr. John Cush RheumNow ( View Tweet)
Retrospective study(2016-2019) of referred newly, suspected (#RA) pts found no value in initial Xrays. Only 32/724 patients (4.4%) had RA like erosions, with Erosions leading to a Dx in only 2 pts (0.3%) & changed prognostic classification in 3 pts (0.4%) https://t.co/fi48WiBgIc https://t.co/skObArXYr6

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Dr. John Cush RheumNow ( View Tweet)
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Rheumatoid Synovium Characterized by Six Cell Type Phenotypes

d Jack Cush, MD

Research work from the Accelerating Medicines Partnership (AMP: RA/SLE) Network, was published in Nature and more specifically characterizes RA synovium into several cell-type abundance phenotypes (CTAPs). Could CTAPs known disease features or more effective future therapies? 

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Arthritis Increased Amongst US Veterans

d CDC

A recent CDC reports estimates that in 2019–2021, 21% of U.S. adults (53.2 million) have physician diagnosed arthritis. Now, an updated report shows a larger number (~33%) of U.S. veterans having diagnosed arthritis. Compared to nonveterans, this prevalence was double in men, and 60% higher in women.

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Patients Don't Read Textbooks RA patient unresponsive to biologics, now has enthesitis; what to do? QD Clinics are sponsored by RheumNows Coverage of #ACR23 live from San Diego https://t.co/hlacYXm0Nh https://t.co/52Xy3E8kXi

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Dr. John Cush RheumNow ( View Tweet)
RA erosions bone ACR

AI Identifies and Predicts Radiographic Change in Rheumatoid Arthritis

d ACR

The American College of Rheumatology's (ACR) has published a preview of new research from ACR Convergence 2023 showing that AI and a deep learning system could accurately identify and predict joint space narrowing and erosions in hand radiographs of patients with rheumatoid arthritis (RA).

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X-Rays Questioned for Diagnosing Early Rheumatoid Arthritis

d MedPage Today

Routine hand and foot radiographs in more than 700 patients being evaluated for rheumatoid arthritis (RA) made almost no difference in diagnosing the condition nor in predicting its course, Dutch researchers said.

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Biologics, #RA and Risk of skin CA (NMSC) is complex. - RA alone is a risk for NMSC 49K study of ABA & NMSC ; - In RCTs, risk same w/ ABA & PBO - Registries & Claims data: equal w/ ABA, csDMARDs. b/tsDMARDs - Pooled obs data shows slight ABA risk https://t.co/tp6F0cJWug https://t.co/u6UdAUZqoc

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Dr. John Cush RheumNow ( View Tweet)
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Incidence, Microbiological Studies, and Factors Associated With Prosthetic Joint Infection After Total Knee Arthroplasty

d Jack Cush, MD

A study of nearly 80,000 US veterans who underwent primary knee joint arthroplasty (TKA) showed  the incidence of prosthetic joint infection (PJI) was highest in the first 3 months and remained elevated through 12 months compared with 12 months or more after surgery.

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UK biobank population study shows a bidirectional assoc. betw RA & ILD (each @ incr risk for the other). In non-COPD pts, RA increased risk of COPD (HR=1.65) & in non-RA pts, COPD had a higher risk of future RA (HR=1.67). Both mediated by inflammation https://t.co/imn4ddV7CS https://t.co/UZaszEnCqt

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Dr. John Cush RheumNow ( View Tweet)
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Anakinra Effective in Systemic JIA, Irrespective of HLA-DRB1 and IL1RN Variants

d Jack Cush, MD

A prospective study of first line use anakinra in systemic juvenile idiopathic arthritis (sJIA) proved to be effective and without potentially allergic lung reactions.

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New download available, titled "Dealing with Infections" https://t.co/hsOuJoFokg https://t.co/G3MZ9BQo0X

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Dr. John Cush RheumNow ( View Tweet)
Oral Surveillance Study Alters Practice at VA Safety risks found in a postmarketing trial with the JAKi tofacitinib (Xeljanz) appear to have influenced prescribing patterns across the class for RA patients in the VA health system, researchers found. https://t.co/6WktHCkrI1 https://t.co/8wpAeLsBbw

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Dr. John Cush RheumNow ( View Tweet)
Metanalysis of 26 studies (2252) pts w/ HBsAg-/HBcAb+ RA treated with b/tsDMARDs, shows the pooled HBV reactivation rate was 2.0% HBV reactivation higher w/ RTX (9%), ABA (6%), JAKi (1%); none w/ IL-6i or TNF-i More reactivation if pt is HBsAb- (OR=4.56) https://t.co/V60nkUSpjj https://t.co/jnZKnY0Zuk

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Dr. John Cush RheumNow ( View Tweet)
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Late Should Not Be Less (11.3.2023)

d Jack Cush, MD

Dr. Jack Cush reviews the news, journal reports and regulatory approvals from the past week on RheumNow.com.

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Study of LATE-onset RA (>65y), shows DMARD initiation is low in LORA; despite current clinical practice guidelines recommending early aggressive Rx. Among 3,373 LORA pts (age77 yrs), only 29% initiated on a DMARD (28.9%). https://t.co/bWHaiiSMVl https://t.co/NmrDeG8UPW

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Dr. John Cush RheumNow ( View Tweet)
256 Early RA pt cohort followed 10yrs showed SDAI sustained remission(n 48) had less 10 yr Xray progression (mTSS 4.06), vs sustained LDA (14.6) or MDA/HDA (21.04). Sustained remission pts were younger, lower HAQ & mTSS scores; less need for GC & bDMARDs https://t.co/92L7RTCx82 https://t.co/4uZBydcfRM

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Dr. John Cush RheumNow ( View Tweet)

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