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Short-Term (not Long-Term) Benefits to Intraarticular Hip Steroid Injection
A single ultrasound guided intra-articular hip corticosteroid injection can be quite effective in patients with hip osteoarthritis (OA).
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TNR Recap: What Patients Say about PsA
Watch this outstanding and informative Tuesday Nite Rheumatology, held on April 5th, 2022 which featured a Patient Perspectives panel discussion, hosted by Dr. Jack Cush.
PsA Panelists included:
- Tena Brown
- Christine Lindsay
- Ashley Krivohlavek
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Deucravacitinib, TYK2 inhib, studied in phase II trial 203 active PsA pts randomised to PBO, or DEUC 6 mg or 12 mg qd. At wk 16 ACR-20 responses were significantly higher with DEUC 6mg (53%, p=0.0134) and 12 mg (63%, p=0.0004) vs PBO. https://t.co/0nvutsXHsI https://t.co/jh43zCbdZx
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Dr. John Cush RheumNow ( View Tweet)
Differences between Palpated & Ultrasound Joint exams in 155 #PSA patients. 5616 joints - found 18.5% tender, 9.8% swollen, 20.4% w/ US GS ≥ 2 and 5.2% had US PD ≥ 1. Joints that were both tender and swollen more likely to have GS ≥ (44%) https://t.co/nWI7jLdkWp https://t.co/iRNsqWYScM
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Dr. John Cush RheumNow ( View Tweet)
Rheum Comanagement of Psoriasis
https://t.co/vXF4t2IIoW
QD Clinic is sponsored by RheumNow's PsA All the Way Campaign in April 2022 https://t.co/fDVx49XtYP
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Dr. John Cush RheumNow ( View Tweet)
“Do as much as possible for the patient, & as little as possible to the patient.” (B Lown). JAMA review of Antithrombotics in COVID-19 says all hospitalized COVID pts with COVID-19 should recv anticoagulation with heparin; no proven value to anti-Plts Rx https://t.co/ZfaH4FiRy1 https://t.co/DW8BGKjfnX
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Dr. John Cush RheumNow ( View Tweet)
Dactylitis Indicates a Severe PsA Phenotype
https://t.co/bUg15czr1Q https://t.co/bnawRJ20jj
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Dr. John Cush RheumNow ( View Tweet)
Among 1033 #PSA pts - 37% were obese. Obese PsA pts had higher PsAQoL, HADS-Anxiety, HADS-Depression, DAPSA, DAS28-CRP, BASDAI, BASFI, HAQ &FACIT scores (p<0.05). BMI affects QOL, depression, disease activity, fatigue https://t.co/6PD8G6xFnk https://t.co/Wlgp0gJGbK
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Dr. John Cush RheumNow ( View Tweet)
This week's Daily Download includes 9 slides covering Moll & Wright classification; epidemiology & prevalence; factors; skin & joint images, and more.
https://t.co/Pr7vODmmnr https://t.co/TEzUy5r4rZ
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Dr. John Cush RheumNow ( View Tweet)
Australian study from 2 #PSA clinics PsA clinics compared RAPID3 score to MDA, very low disease activity (VLDA) & DAPSA. 93 pts showed RAPID3 correlated w/ ROC AUC for VLDA (0.94) and DAPSA (0.96) https://t.co/x9G8wTpeS6 #PsAlways https://t.co/WuseKMoiJj
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Dr. John Cush RheumNow ( View Tweet)
QD Clinic - PsA Lessons from the Clinic
Does the Moll & Wright Classification of PsA hold up?
QD Clinic is sponsored by RheumNow's PsA All the Way Campaign in April 2022
https://t.co/zskcsZ4kkW https://t.co/QZOb09wGyp
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Dr. John Cush RheumNow ( View Tweet)
Czech registry compared drug survival csDMARDs vs TNFi monotherapy. Drug retention higher w/ combo (47 vs 23 mos; p < 0.001) than TNFi monotherapy. 5 yr survival was better 45% vs 26%; Combo w/ MTX > other csDMARDs (p = 0.003). https://t.co/pjbXwEQ53K https://t.co/nZj64Wk3Pt
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Dr. John Cush RheumNow ( View Tweet)
520 RA pts were screened with FibroScan (liver fibrosis)- F3 or F4 liver fibrosis seen 13.3% of controls vs 12.7% arthritis pts. MTX was not significantly correlated w/ higher FS scores. Liver stiffness was correlated w/ BMI, waist, male , age. https://t.co/iKvsITCs33 https://t.co/Dqos1MT431
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Dr. John Cush RheumNow ( View Tweet)
Steroids associated with adverse events during pregnancy @UmaMahadevanIBD @MayoClinicGIHep https://t.co/VR5CZUH1S7
Edward Loftus EdwardLoftus2 ( View Tweet)
Avacopan efficacy in renal failure in AAV. Appears to have benefit in renal disease that is more marked the more severe the disease is #Vasculitis22 https://t.co/3zsxjTLj62
Richard Conway RichardPAConway ( View Tweet)
The striking and most welcome streak of US Covid hospitalizations going down every single day since mid-January continues, now well below the prior pandemic nadir, and even after facing BA.2 variant dominance in parts of the country weeks ago 👍 https://t.co/WUZUCb2TOK
Eric Topol EricTopol ( View Tweet)
#ClinicalPearl Overall #azathioprine wins for maintenance of remission in ANCA associated #vasculitis with equal remission in MPO+ but less with AZA inPR3+. So use AZA but if not tolerated sometimes MMF is ok. Otherwise consider #Leflunomide or if bad organ involvement #Rituximab https://t.co/efi8cKQ36B
Janet Pope Janetbirdope ( View Tweet)
ALEVIATE - small study of Alemtuzumab (anti-CD52) in 23 refractory ANCA-Assoc vasculitis or Behcets— 16/23 (70%) had either complete (6/23, 26%) or partial (10/23, 44%) response at 6 months. 10 SAE in 7 (30%) pts https://t.co/EciG0Mkn4i https://t.co/7UmDA4NxqV
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Dr. John Cush RheumNow ( View Tweet)
RheumNow's PsA Campaign with enhanced coverage of Psoriatic Disease is sponsored by Janssen. All content is chosen by RheumNow + its faculty. #PsAlways https://t.co/is2O1dewcr
Dr. John Cush RheumNow ( View Tweet)
Network metaanalysis studied 46 RCTs biologics in #PsA. Some TNFi's numerically (not signif) better vsn interleukin inhib for ACR resps, but worse on PASI resps (IL-23, IL-17i had better PASI responses); No diff in enthesitis & dactylitis resps https://t.co/AvnoLRVi6C #PsAlways https://t.co/BSl9hVbIx6
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Dr. John Cush RheumNow ( View Tweet)