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Upadacitinib FDA Approved for Ankylosing Spondylitis
Abbvie has announced the US Food and Drug Administration has approved upadacitinib (Rinvoq or UPA) for use in adults with active ankylosing spondylitis, who have not responded or been intolerant of one or more TNF blockers. The recommended dose is 15 mg per day.
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$30 Billion and Counting (4.29.2022)
Dr. Jack Cush reviews the news and journal reports and takes viewer questions this week.
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TLR7 signaling impt to SLE as it drives type I IFN & activation of autoreactive B cells. Nature reports missense TLR7 (Y264H) variant from severe lupus induces guanosine & cGMP & causes murine lupus when introduced into mice. https://t.co/mzAWd3Pke8 https://t.co/knwa7fBLxk
Dr. John Cush RheumNow ( View Tweet)
"Belt & Suspenders" strategy - both COVID-19 vaccination & PrEP (Evusheld) needed to prevent SARS-CoV-2 in moderately to severely immunocompromised pts (transplant, cancer, immunodeficiency) and active poorly controlled autoimmune Dz https://t.co/RmflniD7rD https://t.co/K7pmQtqcOb
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Dr. John Cush RheumNow ( View Tweet)
TONIGHT! Join us at for Tuesday Night Rheumatology at 7pm ET.
This webinar will share highlights from these lectures followed by live audience Q & A:
Treatment Choices in Refractory RA
Adherence to Rheumatoid Therapies
Precision Medicine in RA
https://t.co/8t6z8Y3JR9 https://t.co/xmIRA7faP5
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Dr. John Cush RheumNow ( View Tweet)
Rheumatologic diagnosis through hand exam by Dr. Sarah Chung @ACPinternists #rheumatology #rheumtwitter #MedEd #rheumatoidarthritis #BJHM #Hospitalmedicine #IM2022 #MedTwitter 👇🏽 https://t.co/qR4zNa4NcX
Brown Journal of Hospital Medicine BrownJHM ( View Tweet)
Patient with new onset Colitis while on secukinumab, but is this drug-induced?
https://t.co/tpipGFOHI4 https://t.co/h4QujJdU8O
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Dr. John Cush RheumNow ( View Tweet)
Leflunomide responses in #RA assoc w/ high metabolite levels (A77 1726). In 115 LEF Rx Pts, 40% had LDAS/remission. A77 1726 levels neg correlation w/ DAS28-ESR (r = − 0.42, p < 0.001). Levels >10µg/mL & LDAS PPV 70%; NPV 93% https://t.co/V32wUGVWLM https://t.co/L9DwZBwet9
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Dr. John Cush RheumNow ( View Tweet)
Hyperuricemia as a biomarker of severe #PsA? Study of 242 PsA pts 30% had hyperuricemia & 6% had gout. Hyperuricemia was significantly associated with age, comorbidity, perph polyarthritis, Jt destruction, less response to treatment. https://t.co/NiPTbknD57 https://t.co/HOC2Bev4R6
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Dr. John Cush RheumNow ( View Tweet)
We completed a whole month of super-charged, focused coverage & education on #PsA.THANKS to the many mavens who contributed! In PSA - "Unless someone like you cares a whole awful lot, nothing is going to get better. It’s not." -Dr. Seuss, The Lorax https://t.co/Y58klwbS4V https://t.co/f2pnuypwyr
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Study of 33 #RA pts finds nearly half had peripheral neuropathy (48.5%); sensorimotor in 64.7%, motor in 17.6%. Neuropathy was NOT associated with age, gender, disease activity, functionality, or falls https://t.co/r2aQI2cm27 https://t.co/OOQlWkCAft
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Dr. John Cush RheumNow ( View Tweet)
Prolonged TNF Inhibitor Use Delays Sacroiliac Progression
https://t.co/dz4d8q8XSy https://t.co/NWCAb0OH7B
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Dr. John Cush RheumNow ( View Tweet)
Intraarticular Steroids in Hip Osteoarthritis - Do They Work?
https://t.co/AP9jo96xQo https://t.co/tYvP20Qpqh
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Dr. John Cush RheumNow ( View Tweet)
Playback now available! Watch our Tuesday Nite Rheumatology, held April 26th, 2022, which featured a Journal Club panel discussion about two important studies.
https://t.co/RjFRFt6oJQ https://t.co/zOxCDC1atS
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Dr. John Cush RheumNow ( View Tweet)
Biologics for JIA? Not So Fast, Say Insurers
It's not a simple matter to prescribe tumor necrosis factor (TNF) inhibitors for patients with juvenile idiopathic arthritis (JIA), at least those with insurance, a single-center study found.
https://t.co/w4A5sgv3fU https://t.co/coVh3zui2z
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Dr. John Cush RheumNow ( View Tweet)
Arthritis Predicts Hepatic Fibrosis in Hemochromatosis
https://t.co/AHnRkvq2wo https://t.co/zbl3HQRZCX
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Dr. John Cush RheumNow ( View Tweet)
Today the FDA expanded the indications for upadacitinib (Rinvoq) to include ankylosing spondylitis - specifically for adults w/ active ankylosing spondylitis after failing a TNF blockers or other DMARDs. https://t.co/A9QhT98Djj
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Dr. John Cush RheumNow ( View Tweet)
Study of PCP Dx irritable bowel dz; 459 randomised to 8 weeks of oral antispasmodics or diet (low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP). Better responses with diet (71% vs 61%; p=0.03). Better adherence w/ diet. https://t.co/gmn45yQmuB https://t.co/8SP5Vfx71z
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Nature study shows videoconferencing inhibits creativity (idea generation) because it focuses communicators on a screen, which prompts a narrower cognitive focus. Yet, virtual interaction might increase decision quality. https://t.co/0yTEcmtKye https://t.co/ruwOj9qJ9J
Dr. John Cush RheumNow ( View Tweet)
Pregnancy outcomes in systemic sclerosis (SSc) studied in 154 pregnancies from SSc, SLE, APS, & controls (2008 to 2019). Adverse Preg Outcomes APO significantly higher in SSc vs HC (61% vs 10%) w/ more miscarriages, preeclampsia, SGA & preterm births https://t.co/P3uksmJy6V https://t.co/nTtgwjdGgL
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Dr. John Cush RheumNow ( View Tweet)