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3-4-5 Rule (5.26.2023)
Dr. Jack Cush reviews more than a dozen news, journal articles and RNL highlights from this past week on RheumNow.com.
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Prevalence of Psoriatic Arthritis, Spondyloarthritis and Rheumatoid Arthritis in Norway
Recent reports have suggested a rising and unrecognized number of patients with psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) compared to rheumatoid arthritis (RA).
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Lupus Landmark Study to Accelerate Personalized Lupus Treatments
EurekAlert!
The Lupus Research Alliance and its clinical research affiliate Lupus Therapeutics today announced the launch of the Lupus Landmark Study, a groundbreaking observational research study to accelerate the development of personalized treatments for people living with lupus.
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Ph 3 study 800 ICU pts w/ severe community acq pneumonia shows those on IV hydrocortisone had lower mortality at day 28 (6.2% vs 11.9%; P=0.006), less intubation (18% vs 29.5%), less vasopressors (15% v 25%) vs PBO; no Diff w/ infx rates or GI bleed https://t.co/BjIM8UJXZS https://t.co/389CZovrZm
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Watch our video presented by leading expert Dr. Michelle Petri to learn why complete renal response matters in #LupusNephritis. #SponsoredbyGSKUSMA
https://t.co/XFZH5HprH4 https://t.co/PYfHy6uoZt
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Dr. John Cush RheumNow ( View Tweet)
AxSpA is primarily a genetic disease
- clusters in families, especially HLA-B27+ first degree relatives
- genetic testing for asymptomatic relatives not recommended
@RheumNow #RNL2023 https://t.co/WeNApLE5to https://t.co/zDzHfdmpCG
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⚠️Beware not all bone marrow oedema =#AxSpA on MRI !
Signal seen in 17% volunteers at SIJs
@DrPoddubnyy
#RNL2023 https://t.co/c4gqnBzdnO https://t.co/kZiX8r62aY
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Risk of familial AS is 19.4%, Reveille #RNL2023 @RheumNow https://t.co/7CzaXgqkPG https://t.co/KrmKGblVmd
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"50 years ago in April we discovered HLA B27." Dr. Reveille #RNL2023 @RheumNow
Dr. John Cush RheumNow ( View Tweet)
Bone marrow edema was found in healthy individuals, Denis Poddubnyy #RNL2023 @RheumNow https://t.co/1n6E2QuGut https://t.co/y9Zzw6rdqN
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What to look for( MRI ), Denis Poddubnyy #RNL2023 @RheumNow
STIR: inflammation
T1 erosion, fatty changes
VIBE: erosion https://t.co/enHned1acr
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FRAX Tool is Suboptimal in Predicting Osteoporosis Fracture Risk in Younger Post-menopausal Women
https://t.co/oNTKZXSrzn https://t.co/OlbCuSuLlo
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In the UK, MHRA has somewhat softened its warnings on Febuxostat use in gout - stating use caution if considering Febuxostat in patients with a prior history of major cardiovascular disease; esp w/ high urate and tophi burden or starting ULT https://t.co/y0KhXtgzzG https://t.co/5ZlE0XK8qx
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The Burden of Chronic Pain in US Adults (2019-2020)
Analysis of National Health Interview Survey data shows that the incidence of chronic pain in the USA is high compared with other chronic diseases.
https://t.co/mH6Zb3i3Vw https://t.co/PWI8R6mKJR
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J&J lawsuit against Amgen (Nov 2022) over Amgens biosimilar of Stelara has been settled (terms undisclosed) such that the Amgen biosimilar cannot be US marketed until 1/1/2025. Stelaras 2022 revenue was $9.7 billion https://t.co/NVgBsBNxk1 https://t.co/Fj8rn05RW0
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Women’s health research lacks funding – these charts show how -- Nature has published a very slick/graphical representation of the deficient research funding (US NIH & UK UK Medical Research Council) of diseases affecting women. https://t.co/hJ8DzKxHeW https://t.co/aHoQTKOlRF
Dr. John Cush RheumNow ( View Tweet)
With all the new adalimumab biosimilars happening in 2023, where's the pen? Now the FDA has approved an ADA biosimilar, Cyltezo, Autoinjector Pen! https://t.co/yyyPa9d2Ye https://t.co/MuAnfJ0DsB
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A call for the NIH to address disparities in women’s health research funding. In 1993 Congress mandated NIH include women/minorities in clinical trials. But 30 yrs later, only 11% of NIH budget went to womens diseases https://t.co/8yzUTD1Ufq https://t.co/27W6MnRCFx
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Retrospective cross-sectional EMR study from Israel compared GI Dz in 18,598 FM pts vs 36,985 controls. FM significantly assoc w/ IBS (OR 4.61), GERD (OR 2.62), PUD (OR 2.13), celiac Dz(OR 2.08), IBD ; But not w/ GI malignancies https://t.co/mpLb3rE0CB https://t.co/mySSXC5sjA
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SLE & dsDNA: 3,484 SLE pts (over 37,582 visits) - 29.5% had persistently dsDNA+ & 34% had fluctuating dsDNA.results & both assoc w/ SLE flares (HR 1.56 & 1.46). Doubling of dsDNA assoc w/ 33-36% increased risk of flare (p=0.009) https://t.co/quVlHrfSl3 https://t.co/DkD3h1wV6w
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