Epigenetic Changes to Inflammasome Found in Autoinflammatory Syndromes

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The gene mutations underlying inflammasome activity have been well described, but there appears to be variable penetrance among patients with the same gene mutation, suggesting additional mechanisms may influence disease expression.

Lupus Patients Genomically Stratified to Explain Treatment Responses

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Systemic lupus is a clinically heterogeneous disorder, unified by requisite clinical features and exuberant humoral response to unknown triggers.  While the diagnosis is easy, the disease course and management can be complicated and challenging.  

Family History and Rheumatoid Arthritis

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GWAS Reveals Shared Susceptibility Locus Between RA and SLE

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While the phenotypes of RA and SLE are quite different, genome-wide association studies (GWAS) performed in the past have shown a genetic overlap between both.

HLA-B*5801 Testing Needed in Asians and Blacks with Gout

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Choi and colleagues analyzed US hospitalizations (2009–2013) to assess the frequency and racial distribution of patients hospitalized with Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) related to the use of urate-lowering (ULT) therapy (predominantly allopurinol).

Lupus Patients Genomically Stratified to Explain Treatment Responses

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Systemic lupus is a clinically heterogeneous disorder, unified by requisite clinical features and exuberant humoral response to unknown triggers.  While the diagnosis is easy, the disease course and management can be complicated and challenging.  

Differences in Diuretic-Induced Gout

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Diuretics are frequently implicated causes of hyperuricemia and gout.  And there are gout variants wherein age, renal dysfunction and diuretic use may give rise to gouty attack in the hands of women with nodal osteoarthritis.

Smoking and Age Linked to Development of Inflammatory Arthritis

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A prospective cohort of RA first-degree relatives were prospectively studied for genetic and environmental factors (smoking, body mass index, education, and parity) and RA-related autoantibodies that may influence future development of inflammatory joint symptoms over a 2 year&nbsp

Genetic Basis for Pediatric Autoimmune Diseases

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Researchers at CHOP have published their investigations into the heritability of pediatric autoimmune diseases that affects roughly one in 12 persons.

Funding for Rheumatology Research in Decline

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The Rheumatology Research Foundation and Rheumatology News report that research projects funded by the National Institutes of Health (NIH) dropped by 52% from 2010 to 2014, while the number funded by private foundations fell by 29% over that period.

Fibromyalgia Update: Genes, Hyperbaric Therapy & Conflicts of Interest

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An Israeli crossover trial analyzed the efficacy of hyperbaric oxygen therapy (HBOT) in 60 patients with fibromyalgia.

Blau Syndrome - the Prototypic Autoinflammatory Granulomatous Disorder

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The defining triad of Blau's syndrome includes granulomatous polyarthritis, dermatitis and uveitis.  This rare, monogenic, autosomal dominant disorder stems from a "gain in function" mutation of the pattern recognition receptor NOD2.