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Fever Pitch (7.15.2022)
Dr. Jack Cush reviews the new studies and drug approvals and new insights into febrile disorders from the past week on RheumNow.com
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QD Clinic - Stills (or Not); A Wife's Letter
A letter from the wife of a hospitalized febrile patient says it all.
But, is this Still's disease or not?
https://t.co/MpPbDU9ZTB https://t.co/BqpusOKKLq
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213 #SLE pts were screened for Cryoglobulinemia (2013 -2017); CG is frequent in SLE (66%), but mostly asymptomatic. Mean levels 40mg/L (0-228). Cryo Vasculitis in 15% w/ purpura, ulcers, digit ischemia, arthritis, GN (5%) or CNS (19%) https://t.co/R6xUJldgC2 https://t.co/mwsSTI3ztk
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Can Antimalarials be Withdrawn in Quiescent Lupus?
Antimalaria (AM) therapy is a cornerstone to the management of systemic lupus erythematosus (SLE), yet a recent study suggests that slowly tapering AM yields a lower rate of SLE flares.
https://t.co/dYJy5BOKay https://t.co/pgz694ep2G
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Still’s Disease FAQs
What is the classic 'triad' of Still's disease? Does it affect males and females equally? What are typical lab findings? Which drugs are effective at treating Still's, and which ones are not? What about complications? Read on...
https://t.co/rsFHNPwo9Y https://t.co/AUP1GpbDaN
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Ustekinumab (IL-12/23i) phase 2 study was successful in #SLE; but the phase 3 LOTUS study of 512 pts, UST was NOT superior to PBO (SRI-4 44% v 56%) at 1 year. Study was halted for lack of efficacy (but no safety concerns). https://t.co/uMY5uPPabA https://t.co/nG2RO6oEJQ
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Metanalysis (48 pubs, 145 refract pts) of JAK inhibitors in myositis (DM, JDM) shows significant improvement in skin lesions, muscle weakness, and ILD. https://t.co/cYZ1YEGBOr https://t.co/MDNTSje6a2
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10% of PsA is PsA Sine Psoriasis - how to differentiate from seroneg RA? PsA sine PsO pts have peripheral arthritis, no skin dz, but may have axial sxs, +Family Hx or nail psoriasis, dactylitis, enthesitis, DIP involvement. https://t.co/2RjGU6Fw2j https://t.co/r7Dsqtksh5
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Watch: Comanagement of Psoriasis and Psoriatic Arthritis
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New download available! We're providing an introduction to Still's Disease.
https://t.co/67XzncaUef https://t.co/gaMNGk0grn
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MTX + Pegloticase Combo FDA Approved
Horizon has announced that the FDA has approved the expanded labeling of pegloticase (Krystexxa) injection to be co-administered with methotrexate (MTX), to improve response rates in patients with uncontrolled gout.
https://t.co/D71dmMuB9B https://t.co/jonfLqQ0lj
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Proposed investigations (findings) in the diagnosis of Stills disease: - CRP, ESR, Ferritin (high) - W/U for infection, cancer (negative) - Serologies (negative) - consider Imaging (CXR, CT, US, PET) https://t.co/ByNSq8YACC https://t.co/BdhfRjPA6L
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New podcast ready for download!
Fever Pitch--Dr. Jack Cush reviews the new studies and drug approvals and new insights into febrile disorders from the past week.
https://t.co/GdntsVNyfS https://t.co/3QdJHNlIKQ
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Should Physical exercise be recommended in dermatomyositis and polymyositis: a systematic review of 19 studies and 298 patients showed significant improvements in strength & aerobic capacity without change in CK levels or exacerbations https://t.co/G09ITAku2U https://t.co/6Mj0UAgkDE
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MRP8/14 as a Biomarker in Systemic Juvenile Idiopathic Arthritis
A large cohort study of children with febrile disorders has demonstrated the diagnostic utility of MRP8/14 in diagnosing systemic JIA patients (SJIA) in clinical practice.
https://t.co/Gma3h9Iuqn https://t.co/7GOeES4bbA
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RTX Induction and Maintenance in Older ANCA–Associated Vasculitis Patients
A cohort study suggests that RTX use among patients 75 years and older with ANCA–associated vasculitis (AAV) is efficacious but also has a high risk of serious adverse events.
https://t.co/HF9hyQcHZV https://t.co/xpDSohFcRK
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Viscosupplementation Ineffective in kOA
The BMJ has published the results of a metanalysis showing strong conclusive evidence that viscosupplementation in kOA has minimal effects on pain/reveals strong of an increased risk of adverse events.
https://t.co/hOy0JczC4I https://t.co/Hc2rwbZS3q
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Immunoprofiling of synovial CD4+ T cell subsets shows that ACPA+ pts differ from ACPA- RA by having high expression of adhesion G-protein coupled receptor 56 (GPR56) on synovial CXCL13high TPH CD4+ T cells expressing LAG-3 https://t.co/LQ77CIdh9o https://t.co/chfmLfIqeF
Dr. John Cush RheumNow ( View Tweet)
Ustekinumab (IL-12/23i) phase 2 study was successful in #SLE; but the phase 3 LOTUS study of 512 pts, UST was NOT superior to PBO (SRI-4 44% v 56%) at 1 year. Study was halted for lack of efficacy (but no safety concerns). https://t.co/X5CKYVFxg5 https://t.co/6HVw6AMJPL
Links:
Dr. John Cush RheumNow ( View Tweet)
QD Clinic - Stills (or Not) with Hives
What do you think? 40 yr. woman with fevers, hives, and LFTs.
https://t.co/IZNnWzerOL https://t.co/sUGPuy2tKC
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Dr. John Cush RheumNow ( View Tweet)
