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Claims data looked at 21,114 #RA & #SLE pts - 4.3% had CV Death. The risk of CVD was worse w/ HCQ nonadherence (HR 1.08; 0.91-1.31) and better w/ HCQ adherence (HR 0.51;0.42-.66) HCQ nonadherence shows higher CV mortality #ACR21 Abst# 1909 https://t.co/di1mBliMN6
Dr. John Cush RheumNow ( View Tweet)
Retrospective cohort study FORWARD databank :
⭐️ 🔼opioid use was associated with higher HAQ-DI and BASDAI scores among patients with PsA or AS
Annualized avg opioid use and costs 🔼with 🔼HAQ-DI and BASDAI scores for patients in both cohorts
Abst#1117 #ACRBest @RheumNow https://t.co/KB9QUITbAe
swethaann23 swethaann23 ( View Tweet)
#ACR21 TM18
⭐️Spontaneous coronary artery dissection (SCAD) of LAD
▶️ +Sicca, Photosensitivity, malar erythema, alopecia, oral ulcers, arthralgias
▶️ ANA negative, dsDNA HIGH
Rare case of ANA negative SLE with odd presentation!
https://t.co/jfmVtZ4iOV @RheumNow https://t.co/pMHcColeUn
Links:
Eric Dein ericdeinmd ( View Tweet)
SpA & Pregnancy Outcomes?
➡️SpA pts txed w/ bDMARDs at conception are not at higher risk for adverse pregnancy outcomes compared to those w/o bDMARD
➡️Stopping bDMARDs after conception assoc w/ ↑ dz activity during pregnancy + after birth & ↑flares
Abst#1730 #ACR21 @RheumNow https://t.co/Y4c7vI0cgS
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
#ACR21 Thieves TM17
Fascial and muscle edema + ecchymoses + petechiae
❌🥝🍎🥦🍅 in diet
A: Scurvy
⭐️Skin exam with ecchymoses, corkscrew hairs are your clues!
@Rheumnow https://t.co/AUvme7aeDn https://t.co/4crnYzxfc7
Links:
Eric Dein ericdeinmd ( View Tweet)
60% don’t use pneumocystis prophylaxis #PJP in #lupus #SLE @RheumNow #ACR21 https://t.co/AVf97xJhtL
Janet Pope Janetbirdope ( View Tweet)
Use of #rituximab is same in Rheum pts during #COVID19 says 1 in 3 #rheumatologists but less use say 60%! #ACR21 @RheumNow https://t.co/ginurWvkOC
Janet Pope Janetbirdope ( View Tweet)
Press Conference Arthritic Disease
Abs 1451
Ologhobo & colleagues examined impact of virtual exercise program in individuals w/ MSK conditions
Members reported decrease in
- Pain
- Pain interference
- Fatigue
- Stiffness
#ACR21 @RheumNow https://t.co/T5qdlLEYZ0
Akhil Sood MD AkhilSoodMD ( View Tweet)
Top Influencers of #acr21: @ACRheum @rheum_cat @RheumNow @CreakyJoints @RichardPAConway @KDAO2011 @alhkim More 📊 https://t.co/vyMAwjKbqC
Symplur Hashtags healthhashtags ( View Tweet)
*️⃣Abst#1800 observed that a changing pattern of purine, lipid, & amino acid metabolites occurred during transition from PsO to PsA.
*️⃣Compared to pts w/ Pso that didn't progress to PsA, those that progressed had elevated levels of guanine!
Potential biomarkers?
#ACR21 @RheumNow https://t.co/iQh1ZapDMB
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Dementia is ⬆️in #RheumatoidArthritis says Elena Myasoedva but #RA has more DM &CV disease which ⬆️dementia. Need to separate vascular dementia from Alzheimer’s. When I trained we thought less dementia in RA -likely not true. More work is coming. 9T213 aging hub #ACR21 @RheumNow
Janet Pope Janetbirdope ( View Tweet)
Post-Hoc of the ASCORE trial showed the following b/l characteristics were most likely associated with remission (per DAS28, SDAI, CDAI) in mod-severe RA patients treated w/ SQ Abatacept:
⭐️Seropositivity
⭐️no prior bMDARD use
⭐️low HAQ-DI
⭐️low BMI
Abst#1228 #ACR21 @Rheumnow https://t.co/NvJoSWScZs
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
⭐️Immune phenotyping of 45 patients with Pso and 41 PsA pts showed a number of cell subsets significantly different in Pso vs PsA
⭐️Future possibility of using a combination of selected immune cell subsets as a method for detecting PsA in Pso pts
Abst#1774 #ACR21 @Rheumnow https://t.co/ER1MPOvMa6
swethaann23 swethaann23 ( View Tweet)
#ACR21 #AbstrL17 In pts treated with Rituximab, arrange a 3rd primary dose ASAP regardless mRNA or vector #COVID vaccine. An RCT of N=60 pts who did not seroconvert after primary dose, overall 94% either seroconverted/new T-cell response @RheumNow #ACRBest https://t.co/F15j93OFE4 https://t.co/tXoisoYthx
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Abst#1774 identified a blood-based immune profile with a machine-learning approach that discriminates PsA from Pso.
➡️↑ proportions of differentiated CD4+CD196+CD183–CD194+ and CD4+CD196–CD183–CD194+ T-cells in PsA
#ACR21 @RheumNow https://t.co/64uhJCd2qo
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Fibromyalgianess Glucocorticoid Persistence in RA Patients: Dr. Sheila Reyes ( @RHEUMarampa) discusses abstract #0120 presented at the #ACR21 annual meeting.
https://t.co/9yOM5rSARv https://t.co/Gq2YxbxkmM
Links:
Dr. John Cush RheumNow ( View Tweet)
RheumNow’s expanded coverage of the #ACR21 annual meeting is sponsored in part by @Novartis. All content chosen by #RheumNow & its Faculty.
Dr. John Cush RheumNow ( View Tweet)
Great work from #CATCH cohort. Yes I am biased. @earlyarthritis #ACR21 abst#1661 @RheumNow https://t.co/hogyNEQiWM
Janet Pope Janetbirdope ( View Tweet)
#Guselkimab Better than #ustekinumab for skin& MSK. #Ixekizumab beat ustekinumab for skin. #ustekinumab loses throne in #psoriasis and #psoriatic arthritis except maybe if concomitant inflammatory bowel disease post TNFi? Rapidly evolving PsA Rx. Abst#1773 #ACR21 @RheumNow https://t.co/Dkf2DFFsSK
Janet Pope Janetbirdope ( View Tweet)
COVID 19 Poster Review
Abst 0197
Haibel & colleagues performed open label study on IL-1/IL-6 inhibitor combo
- Majority avoided mechanical ventilation (25/31)
- 2 pts died while on ECMO
- CT Chest findings improved 1 month after treatment
#ACR21 @RheumNow https://t.co/CIJR1Tx8St
Akhil Sood MD AkhilSoodMD ( View Tweet)