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Adherence to Hydroxychloroquine Lowers Lupus Mortality

Jack Cush, MD

A lupus cohort study from British Columbia, Canada has shown that medication adherence with hydroxychloroquine (HCQ) is associated with a 71% to 83% lower mortality. 

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Rhapsody Study: IL-1 Inhibition in Recurrent Pericarditis

Jack Cush, MD

Recurrent pericarditis is a rare, probable autoinflammatory disorder mediated by interleukin-1 (IL-1); and is often refractory to glucocorticoids and colchicine.

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COVID-19 as a Leading Cause of Death in the USA

Jack Cush, MD

The exponential rise in deaths from the coronavirus (COVID-19) in the last several months is put into perspective by JAMA Viewpoint article noting that current US death rates of > 3000 per day from COVID-19 is greater than that seen in one day on September 11, 2001 (9/11 attacks, claimed 2988 lives) or by a fictional catastrophe of 15 Airbus 320 jetliners (150 passengers each) crashing daily.

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Rheumatoid arthritis and lung disease in the spotlight at #ACR20

Jeffrey Sparks, MD, MMSc

Rheumatoid arthritis (RA) has long been established to have pulmonary manifestations such as interstitial lung disease (ILD), and several research groups are pursuing this respiratory burden of RA at #ACR20. 

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FAST, FREED, CARES, & CONFIRMS: A Run-Down on the Black-Box Blues of Febuxostat

Meral K. El Ramahi, MD, FACP, FACR

Febuxostat, a nonpurine xanthine oxidase inhibitor used in the treatment of chronic gout to lower serum urate levels, received bad press in 2019 after the US Food and Drug Administration (FDA) placed a black-box warning on the medication’s label suggesting that it increases the risk of cardiovasc

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ENTRACTE trial studied the risk of major adverse CV events (MACE) in 3080 RA pts Rx with tocilizumab (TCZ) vs etanercept (ETN), and found no increased risk of MACE in TCZ patients compared to ETN (HR 1.05 (95% confidence interval 0.77–1.43). https://t.co/KpOEeVAAxx

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Dr. John Cush RheumNow ( View Tweet)

#BestACR20Tweets RT @ATSCPAssembly : Dr. Dinesh Khanna ( @sclerodermaUM): In post-hoc analysis of focuSSed trial of tocilizumab vs. placebo, disease duration, male gender, elevated acute phase reactants, and anti-SCL-70 Ab have a larger beneficial effect on FVC in early SSc-ILD.

Dr. John Cush RheumNow ( View Tweet)

Lung Cancer Survival With Autoimmune Disease--a recent analysis suggests that patients with autoimmune disease do not have worse survival, even though they may have received less than the standard-of-care treatments. Learn more below. https://t.co/ItVhityI1B https://t.co/tyTKAtGY2O

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Dr. John Cush RheumNow ( View Tweet)
Phase III RHAPSODY trial: open label rilonacept in 86 pts with active recurrent pericarditis (& elevated CRP). Rapid resolution was noted and during the drug withdrawal phase there were significantly fewer recurrences on rilonacept compared with placebo. https://t.co/oEGbsdKe8f

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Dr. John Cush RheumNow ( View Tweet)

#UTSW Rheum Grand Rounds on Sarcoidosis w/ Dr. HSIA - Joints are involved in 15% of pts. Lung sking and ocular involvement predominate https://t.co/G4iWm4pLmO
Dr. John Cush RheumNow ( View Tweet)
#BestACR20Tweets RT @drdavidliew :The 'triple M' irAEs (myositis/myocarditis/MG): one of the rheumatic irAEs where autoAb are freq pos Nice systematic review: any autoAb+ 61% tested MG+ 59% tested MSA+ in 27% tested (18/67, 11 had myositis alone) https://t.co/aQHapPbjw9
Dr. John Cush RheumNow ( View Tweet)
#BestACR20Tweets RT @MeralElRamahiMD : A large observat study showed no difference in risk of major CV events in RA pts that were newly started on either MTX or HCQ. A greater stroke risk but lower risk of MI; hospitalized HF was seen in MTX initiators. #Abst1993 #ACR20

Dr. John Cush RheumNow ( View Tweet)

The Lungs: The Alpha and Omega of RA with Dr. Jonathan Kay #ACR20 https://t.co/zhCRaeKOfu https://t.co/zVwgzu9ULs

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Dr. John Cush RheumNow ( View Tweet)
Citrulline Reactive B Cells Present in Lungs of Risk, Early RA: Richard Conway ( @RichardPAConway) discusses ACR abstract #1445 presented #ACR20 https://t.co/WjcBPay86P https://t.co/JnUVss0FDK

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Dr. John Cush RheumNow ( View Tweet)
#BestACR20Tweets RT @KDAO2011 : The FAST trial had 33% of pts with CVD and pts w/class III/IV CHF weren't allowed in this study; still cautious prescribing febuxostat to pts who have severe CVD until we have more data. https://t.co/eyl2kOjEEU https://t.co/qoQDgRifFg

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Dr. John Cush RheumNow ( View Tweet)
Check out this quick video on lifestyle, clinical risk factors for RA-ILD with Dr. Sheila Reyes (@RHEUMarampa) #ACR20 https://t.co/7LQ7RCtiuj https://t.co/CjjtUauy2u

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Dr. John Cush RheumNow ( View Tweet)
"Rheumatoid arthritis and lung disease in the spotlight at #ACR20" by Dr. Jeffrey Sparks ( @jeffsparks) https://t.co/0Dth0ko5TO https://t.co/e6HQOkXuY7

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Dr. John Cush RheumNow ( View Tweet)
View our video on Abatacept in RA and ILD Patients with Dr Richard Conway ( @RichardPAConway) Dr. Richard Conway discusses abstract #0233 presented Friday at the #ACR20 virtual annual meeting. https://t.co/5zowsDetU1

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Dr. John Cush RheumNow ( View Tweet)

#ACR20 Abstracts on #ILD Rituximab in ILD (all observational) #1053 ➡️ 47 with CTD-ILD: overall improvement or stability at 36m #1051 ➡️ 50 with IPAF: >70% stable or improved at 12m #1047 ➡️ 47 patients CTD-ILD or IPAF: good experience with MMF and RTX #ACRambassador https://t.co/klfVwIH5b6
Sebastian E. Sattui MD, MS SattuiSEMD ( View Tweet)
Latebreaking at #ACR20—Febuxostat was non-inferior to allopurinol with regard to the occurrence of major cardiovascular outcomes in patients with gout: finding from FAST, multicentre, prospective, randomised, open-label, non-inferiority trial https://t.co/cpoNi7zjwi https://t.co/uQyeyepPmj

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The Lancet TheLancet ( View Tweet)
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