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Day 2 Report from ACR21
This report highlights the VITAL trial; the ORAL Surveillance Study; and the Microbiome study of monozygotic psoriasis patients.
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Axial spondyloarthritis with psoriasis or psoriatic spondylitis
PsA commonly affects peripheral joints. In up to a quarter of PsA patients, the spine may be involved and this is known as psoriatic spondylitis (PsSpA). An important research question is whether PsSpA and Axial Spondyloarthritis (AxSpA) with psoriasis are separate conditions or not.
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An important slide showing how UV radiation affects #Immunity
🔅suppress APCs
🔅promotes #cytokine production
🔅inhibits cytotoxic & memory T cells
🔅⬆ monocyte recruitment 👉⬆ IFN
🔸⬆UV exposure, ⬆ risk of dev't/flares of #lupus, DM
@RheumNow #ACR21 #climatechange https://t.co/e9glxfy6wR
sheila RHEUMarampa ( View Tweet)
Interim analysis of AURORA 2 Extension study:
🦋Voclosporin maintained meaningful reductions in UPCR and eGFR remained stable until month 30.
🦋No unexpected new AEs
Promising results!
@RheumNow #ACR21 #ACRBest abs1425 https://t.co/hBB6k0bDYb
sheila RHEUMarampa ( View Tweet)
Identifying Gaps in axSpA: Lessons from European Map of Axial Spondyloarthritis (EMAS)
Dr. Sheila Reyes, ( @RHEUMarampa) discusses the three interesting abstracts were presented by the group of Prof. Marco Garrido-Cumbrera on the EMAS at #ACR21.
https://t.co/Q50kEr5WEU https://t.co/5DScK5krtw
Links:
Dr. John Cush RheumNow ( View Tweet)
CARRA survey in SAID pts reported no change in flare frequency w/ COVID19 but many had reduced intensity of fevers during flares. Majority of pts reported mild to moderate symptoms w/ 1/3 had lingering COVID19 symptoms. Abs 1083 #RheumNow #ACR21 @RheumNow https://t.co/qbfsqvXutt https://t.co/6u33VDIexY
Dr. Rachel Tate uptoTate ( View Tweet)
AxSpA: Geographic Prevalence Association with HLA-B27: Dr. Rachel Tate ( @uptoTate )
Dr. Rachel Tate discusses abstract #0368 presented at the #ACR21 annual meeting.
https://t.co/CnIjlWuKjZ https://t.co/vytIdK9CCo
Links:
Dr. John Cush RheumNow ( View Tweet)
#ACR21 #Abstr1457 Nine more well-phenotyped patients with VEXAS were presented. New info:
💠Peritubular capillaritis & cryo vasculitis
💠Most cs- & bDMARDs had limited efficacy
💠Potential therapy with plasma cell blockade & stem cell transplant
@RheumNow https://t.co/iDwJAdbf4M https://t.co/X4ENz4M91u
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
This post hoc analysis of SPIRIT 1&2 in #psoriaticarthritis pts w/ symptoms indicative of axial involvement showed that Ixekizumab reduced axial symptoms and improved QoL at wks 16 & 24.
Reassuring data.
@RheumNow #ACR21 abs1347 https://t.co/aFixZdiEyx
sheila RHEUMarampa ( View Tweet)
Risankizumab for Active Psoriatic Arthritis with Dr. Robert Chao ( @doctorRBC )
#ACR21
https://t.co/0zskkywWu1 https://t.co/n3qs19rQNG
Links:
Dr. John Cush RheumNow ( View Tweet)
Interesting results where cannabidiol NEG results in RCT in hand OA and PsA. ? Throw out the ‘pot’with the dish water? Did it stimulate appetites? Was pain the same but interference less? Abst#1456 #ACR21 @RheumNow https://t.co/rnz82Paxkr
Janet Pope Janetbirdope ( View Tweet)
Interesting question came up: why would you change a RA patient from JAKi to JAKi?
The main reason I can think of would be if the first JAKi worked a bit (but not enough to continue, or AEs got in the way).
That would clearly favour to better survival
#ACR21 ABST1442 @RheumNow https://t.co/kDiJVbJfit
David Liew drdavidliew ( View Tweet)
#ACR21 #Abstr1484 Hands down one of the most impressive results and trial design. RHAPSODY: Rilonacept led to ⬇️risk of pericarditis recurrence vs PBO (7% vs 74%; HR 0.04). Median time to resolution of pain and CRP were 5 & 7 Days. FDA approved @RheumNow https://t.co/Zty2WnkJEQ https://t.co/xGqt9Lwvjj
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
RheumNow’s expanded coverage of the #ACR21 meeting is sponsored in part by @Novartis. All content chosen by RheumNow & its Faculty.
Dr. John Cush RheumNow ( View Tweet)
Realised i have not been out of house apart from hospital visits 😳🙈#MeTime outdoor in the UK 🇬🇧 Falls season while enjoying #ACR21 talks by the New Masters @RheumNow #Rheumpix https://t.co/HYLKkECvCv
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Loved this session on: Preclinical Rheumatoid Arthritis- Can we stop RA? As a patient advocate living with RA, my providers have always ran tests on my microbiome. The findings have correlated with my disease flares, and was a big trigger overall. #ACR21 @ACRheum Thank you! https://t.co/6hm6hr85JS
Effie Koliopoulos RisingAboveRa ( View Tweet)
Erdheim Chester Disease
👉A histiocytic,myeloid malignancy
👉 “Coated Aorta” Classic peri-aortitis inv. Thoracic & Abdominal Aorta
👉 “Hairy Kidneys” on CT
👉 Abn PET-CT, foamy histiocytes on path
👉 Refer to onc for t/t
#ACR21 ✨Must See✨ session on Pearls by Dr. John Stone!! https://t.co/qobSsPxAhY
Ashima Makol MD AshimaMakol ( View Tweet)
So humbled and honored
Thank you ACR /RRF for the constant support
#ACR21 https://t.co/SAE6ZfYmm5
swethaann23 swethaann23 ( View Tweet)
Dr. Fujimoto provides a wonderful overview of skin findings in DM by antibody
#ACR21 #ACRAmbassador https://t.co/KpOsgKPU7j
Veena Katikineni VeenaRheumMD ( View Tweet)
#ACR21 Rheumatology Secrets & Pearls: @JKolfenbach & Dr. Stone 📚
Unique Pearls Discussed ⬇️
🩺 Auscultate bruits on the back
💊 Oxypurinol levels
🍓 Strawberry-like gingivitis
👃 Human neutrophil elastase (HNE)
♥️ Coronary aneurysm in IgG4-RD
@ACRheum #ACRAmbassador https://t.co/gTyrmUA10r
Mithu Maheswaranathan, MD MithuRheum ( View Tweet)