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Infection or Disease Flare: What Tools Can Help Differentiate?

d Olga Petryna, MD

Differentiation between a flare of disease and infection in patients with autoinflammatory (AI) conditions, where fever is the hallmark, can be extremely difficult. Few studies have evaluated potential differentiators; and having such tools would meet a huge unmet need. 

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Rheumatologists and Health Professionals: Join us tonight for RheumNow's #ACR21 Daily Recap at 7pm Eastern time . Register via the Zoom link below. https://t.co/LLCt4wk1zj Or visit our YouTube channel-RheumNow. https://t.co/7S0YgJKPga https://t.co/pkmI8cLxni

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Dr. John Cush RheumNow ( View Tweet)
Knowledge Bowl at #ACR21 ⭐️Increased susceptibility to a certain most common adult vasculitis is conferred by this HLA allele ➡️HLA DRB10404 @RheumNow

Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)

Knowledge Bowl at #ACR21 ⭐️The first lung fibrosis described in Sjogren's with lung biopsy showing benign polyclonal lymphocytes and plasma cells with a risk for malignant transformation. ➡️Lymphocytic Interstitial Pneumonia @RheumNow

Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)

Get to know your program officer! Plan in advance! Attention to detail! Key takeaways from the NIH Q and A #ACR21 @ashira_md @RheumNow

Bella Mehta bella_mehta ( View Tweet)

You know you made it when you name appears on #ACRknowledgebowl @RheumNow #ACR21 on a question about who deveoped criteria for #AOSD https://t.co/VR5NQOfS3r
TheDaoIndex KDAO2011 ( View Tweet)
Emerging Therapies in Spondyloarthritis: A Promising Pipeline by Dr. Olga Petryna (@DrPetryna ) #ACR21 https://t.co/9ggUAh0YJe https://t.co/WHpQp3GYBe

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Dr. John Cush RheumNow ( View Tweet)
Knowledge Bowl at #ACR21 ⭐️This HLA allele confers a risk for a severe psoriasis phenotype, typically guttate type. ➡️HLA Cw6 @RheumNow

Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)

Abst1344 #ACR21 @RheumNow observational study of pts w/PsA treated w/b&tsDMARD:pts who achieve MDA (22.8% of pts at 6 mo) more likely to maintain the initiated bDMARD or tsDMARD Rx & less likely to switch from the initiated bDMARD/tsDMARD https://t.co/egFDHV3eQs
Olga Petryna DrPetryna ( View Tweet)
#ACRknowledge bowl question asks the 5 D’s of Charcot joint, but really there are 6. #ACR21 @rheumnow. 1. Distended 2. Disorganized 3. Dislocated 4. Debris (intraarticular bodies, which can be seen with synovial osteochondramotosis) 5. Density increased (sclerosis) 6. Destruction https://t.co/g0YsIFsEtv
TheDaoIndex KDAO2011 ( View Tweet)
#ACR21 Abs#1367. Scleroderma pts with absent contractility (AC) associated with diffuse cutaneous disease, cardiac involvement, more severe Raynaud's. ⭐️14/67 AC pts died during study (21%), none without AC ⭐️15/16 Ro52+ pts had AC (p=0.06) https://t.co/GAuOiV5ScC @Rheumnow

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Eric Dein ericdeinmd ( View Tweet)

Knowledge Bowl at #ACR21 ⭐️In this triad seen in TB arthritis, one can see juxta-articular osteopenia, peripheral osseous erosions, and late joint space narrowing ➡️Phermister's triad @RheumNow

Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)

#volcosporin good ~lupus nephritis added to #MMF but underbelly - side effects like but ?less than #cyclosporin. #FDA update - ⬆️hypertension and nephrotoxicity, infection #ACR21 @RheumNow https://t.co/w5nLLSTlrB

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Janet Pope Janetbirdope ( View Tweet)

Knowledge Bowl at #ACR21 ⭐️Which HLA allele confers an increased risk for anterior uveitis and inflammatory sacroillitis? ➡️HLA-B27 @RheumNow

Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)

BAFF & APRIL support B cell development, diff, survival. ALPN-303: Antagonist of both BAFF & APRIL 💠⬇️B cell fxn & Ab production,⬇️Plasma cells 💠⬇️UProt, dsDNA, renal immune complexes (mouse model) 💠Pending human studies https://t.co/kzVpUDuNWs #ACR21 Abst#1429 @RheumNow

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Pedro Castillo _Castillo_Pedro ( View Tweet)

My summary article on some of the many abstracts at #ACR21 on #WorkParticipation in #axSpA. Featured abstracts in this article: #0358 https://t.co/LrZYWqCuOm #0362 https://t.co/flL5MiqDL8 @RheumNow https://t.co/tu5L0yIVIV

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Mrinalini Dey DrMiniDey ( View Tweet)

Are you using less #rituximab in #SLE during #COVID #ACR21 @RheumNow #Lupus hub

Janet Pope Janetbirdope ( View Tweet)

#ACR21 Knowledge Bowl Final Question: Vasculitis Mimics: @RheumNow https://t.co/laD3oO8Uq9
Eric Dein ericdeinmd ( View Tweet)
1st Place in #ACR21 #Rheum Knowledge Bowl Gulls of Galveston Congrats to Daniel Gonzalez and Aparna Das! @RheumNow @UTMBProvost @UTMBInternalMed https://t.co/nXjy0CD1uY https://t.co/fAUTE3V8lo

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Akhil Sood MD AkhilSoodMD ( View Tweet)
Knowledge Bowl at #ACR21 ⭐️This disease featuring purple-red papulosquamous eruptions, on the hands and elsewhere, can have preceding painless erosive symmetrical arthritis at the DIPs, and has a 30% malignancy risk. ➡️Multicentric Reticulohistiocytosis @RheumNow

Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)

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