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‘Cool’ explanation for #COVID toes. Type I IFN response can drive perniosis. Great session of cases from Len Calabrese & Jack Cush @RheumNow #ACR21 7S001 usual suspects https://t.co/v8IX2xxOZ7
Janet Pope Janetbirdope ( View Tweet)
2 year extension study on Upadacitinib in active AS
⭐️ASAS40 response maintained
⭐️MRI SPARCC scores decreased and maintained
⭐️infections most common AE
⭐️NO MACE, lymphoma, skin cancer, GI perforations
Abs#924
#ACR21 #ACRBest
@RheumNow
https://t.co/725IRAOgtW https://t.co/FVUoCi6aoQ
Robert B Chao, MD doctorRBC ( View Tweet)
Jorge Plutzky, cardiologist perspective on RA at #ACR21
⭐️CANTOS: Canakinumab for MACE shows ⬇️ inflammation, no change in LDL. Improvement in MACE events
▶️Plutzky: "Proof of concept study"
@Rheumnow https://t.co/Xi9ZHxMtmu
Eric Dein ericdeinmd ( View Tweet)
Another benefit of DMARD use in RA. Dr Sood reports lower risk of long term opioid use. Very important given the harm of opioids Abstr#587 #ACR21 @RheumNow https://t.co/d1Dharf5jZ
Richard Conway RichardPAConway ( View Tweet)
We need to control not only inflammation but also lipids levels in our patients w/ IA! Dr Plutzky brilliantly talking us through CV risk and RA showing data on how poor LDL control and coronary microvascular dysfunction lead to worse long term CV outcomes.
@RheumNow #ACR21 https://t.co/o6GWHDai5z
Aurelie Najm AurelieRheumo ( View Tweet)
@MilenaGianfran @JYazdanyMD present on differential effects of biologics on CDAI in obese patients with rheumatoid arthritis. Abatacept better than TNFi in obese. Tocilizumab better than TNFi in non-obese. Abstr#0588 #ACR21 @RheumNow #ACRBest https://t.co/UcEpMAmNVw
Richard Conway RichardPAConway ( View Tweet)
Attaining low disease activity in #SLE ⬇️ mortality! More time in LLDAS = #lupus low disease activity state = ⬆️survival in >4000 pts with SLE. Also + was clinical remission on treatment CROT. Treat to a target has come to SLE @RheumNow #ACR21 abst0865 #ACRBest #RheumPix https://t.co/8ld8oncFRR
Janet Pope Janetbirdope ( View Tweet)
The drug retention for SEC and TNFi was similar in this RW study of 279 patients (TNFi 178, SEC 101).In subgroups analyses, age, BASDAI at diagnosis and BMI did not favour any group @RheumNow #ACR21 Abst#0911 https://t.co/g1tIy1qMX1 https://t.co/LHZMxMlzIB
Dr. Antoni Chan synovialjoints ( View Tweet)
Dr. P Crow #PhilipHench provides a tour of research on SLE pathogenesis:
👉discovery of Ab to small nuclear RNAs and the spliceosome
👉T cells' role on B cell differentiation
👉⬆️CD40L on SLE lymphocytes
👉IFN genes and their effects on the immune system #ACR21 @rheumnow https://t.co/6v9O19UUxX
TheDaoIndex KDAO2011 ( View Tweet)
No significant difference in effectiveness/treatment survival of different TNFi in axSpA
Failure of 1st TNFi did not diminish effectiveness of a second TNFi
Abs#938
#ACR21 @RheumNow
https://t.co/SLrOV7wmvU https://t.co/fkpmseVwF6
Robert B Chao, MD doctorRBC ( View Tweet)
#ACR21 #Abstr0686 A study used PET-CT to initially rule out cancer. Interestingly, they found ⬆️median muscle FDG uptake with PET-CT in IIM vs Non-IIM. Need further study on its added value compared to MRI/EMG @RheumNow https://t.co/F0B86ygjI9 https://t.co/eiJnqpU8ft
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Dr. P Crow #PhilipHenchLecture
IFN signature can parallel or predict flares #ACR21 @rheumnow https://t.co/OskxDuKPDH
TheDaoIndex KDAO2011 ( View Tweet)
Abstr 0579
Kim & Colleagues examined predictors of Tx change among RA patients w/ TNFi as 1st line biologic agent
- Females & GC use more likely to switch agent
- Vitamin D use & hx of other immune-mediated diseases (eg. Psoriasis, IBD) less likely to switch
#ACR21 @RheumNow https://t.co/FM5mSWmSNA
Akhil Sood MD AkhilSoodMD ( View Tweet)
@zach_wallace_md on RTX vs CYC remission induction in AAV. Multivariable and propensity score matching. No difference in ESRD or mortality. Real world confirmation of RAVE. Abstr#954 #ACR21 @RheumNow https://t.co/oSauqV8JnD
Richard Conway RichardPAConway ( View Tweet)
Abst0944 #ACR21 #ACRBest @RheumNow microbiom evaluation of MZ twins discordant for PSO reveals Ruminococcus bromii species significantly reduced & two pathways related to tetrahydrofolate biosynthesis upregulated in PSO twins compared to their unaffected siblings (p< 0.05) https://t.co/67ao0l23sI
Olga Petryna DrPetryna ( View Tweet)
#ACR21 Clinical Pearl: Beware of low cholesterol!
Systemic inflammation can lower cholesterol levels! High inflammation and low cholesterol may INCREASE, not decrease risk of CVD!
This is the "lipid paradox"
@Rheumnow https://t.co/dK7hD8zkVP
Eric Dein ericdeinmd ( View Tweet)
Soluble urinary ALCAM previously shown as potential biomarker for LN. Further study showing urinary ALCAM trended with changes in renal-SLEDAI and UPCr.
#ACR21 Abst#3053 @RheumNow https://t.co/IqVJej7yda
Links:
Pedro Castillo _Castillo_Pedro ( View Tweet)
Abst 0947 #ACR21 @RheumNow KikGR x TNFDARE/+ mice study assessed contribution of gut-derived T cells to increased joint inflammation through production of pro-inflammatory cytokines like IL-17 and TNF. Photolabeled gut-trafficked T cells are observed in the Achilles enthesis
Olga Petryna DrPetryna ( View Tweet)
Important to discuss men with #lupus
Nationwide claims study showed increased occurrence of multimorbidity in men with SLE compared to women with SLE #ACR21 @RheumNow @AliDuarteMD Abst#0579 #ACRBest https://t.co/ljflGU84Ro
Bella Mehta bella_mehta ( View Tweet)
No evidence to show increased risk of incident hypertension w/ TNFi use, after accounting for baseline & time-dependent confounding factors, in prospective AS cohort. Abs 0910 #ACR21 #RheumNow @RheumNow https://t.co/1SpQ51ftlK
Dr. Rachel Tate uptoTate ( View Tweet)