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#ACR21 Abst#0910 by @rheum_cat. Do TNFi ⬆️ risk of incident HTN in AxSpa?
⭐️PSOAS cohort: Prosp study from 2003-2018
▶️When adjusted for confounders (obesity, disease activity, NSAID use), insufficient evidence to show ⬆️ risk of HTN w TNFi
https://t.co/DCZ3W8CkOa @Rheumnow
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Eric Dein ericdeinmd ( View Tweet)
Exciting day at #ACR21
I wrote an article discussing COVID 19 in #RheumatoidArthritis discussing the following abstracts
0097 by Hasseli
1445 by @NamrataRheum
L04 by @rheum_cat & @rheum_covid
@rheumnow #COVID19 #RA #JAK #Rituximab
https://t.co/g32ZYHBjQY
Akhil Sood MD AkhilSoodMD ( View Tweet)
#ACR21 Abst#0916. https://t.co/uc5JDVY0ud
Your patient has had 1 yr of remission of AxSpa on Certolizumab pegol, tolerating the medication. What do you recommend @Rheumnow
Links:
Eric Dein ericdeinmd ( View Tweet)
Dr. Thaissa Cotton on SLE + ILD and/or myositis: important given poorer outcomes. Ask pts and listen to those lungs!
💠1.8 cases/100 patient years (14/551 pts in study)
💠92.9% had >=1 med-to-high titer marker
💠⬆️risk if baseline +anti KL-6, Ku, CENPB
#ACR21 Abst#0330 @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
#ACR21 Abst#0916
⭐️AxSpa pts in remission: Full Certolizumab vs 1/2 dose vs PBO
▶️ 85% w/o flare in full dose, 80% in 1/2 dose, just 23% in PBO
▶️ PBO pts with NO flare STILL showed ⬆️ ASDAS, BASDAI, and CRP
🔥Would ⬇️ not d/c Cimzia!
@Rheumnow https://t.co/uc5JDVY0ud #ACRBest https://t.co/fOssPlTEwR
Links:
Eric Dein ericdeinmd ( View Tweet)
We are live! Join us!
RheumNow Daily Recap - #ACR21 https://t.co/hUqx6B2ySD via @YouTube
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Dr. John Cush RheumNow ( View Tweet)
Small numbers but mirrors data from TENOR and plenty to think about here. We clearly want to see sustained remission and Ax details, but very promising!
Definitely on the agenda for the @RheumNow #ACR21 GCA/PMR panel on Wed am with @LCalabreseDO @Sarah_L_Mackie @RichardPAConway
David Liew drdavidliew ( View Tweet)
@benjaminsutu @RheumNow Always steroids first, we learned that the hard way in GUSTO - but yeah, probably something after that, and TCZ is our only b/tsDMARD choice... for the time being
(at #ACR21 - mavrilimumab, baricitinib, secukinumab...)
David Liew drdavidliew ( View Tweet)
Dr. Petri noted that 1 week off of immunosuppressants is adequate for most lupus patients to mount a response. She avoided RTX during the pandemic. In pts who have had inadequate response to 2 or 3 doses of mRNA, she switches them to J&J. #ACR21 #COVI19 CH @rheumnow https://t.co/qNjmx9uTLF
TheDaoIndex KDAO2011 ( View Tweet)
TNFi + JIA = watch the skin! A nearly 3fold increase of paradoxal psoriasis in JIA patients exposed to TNFi reported in the CARRA registry w/ incidence rate the highest on children receiving adalimumab.
#Abst0241 @RheumNow #ACR2021 https://t.co/uXOwV2RlGu https://t.co/8f8mvVUkV2
Aurelie Najm AurelieRheumo ( View Tweet)
Treatment for VEXAS syndrome. It is steroid responsive. Avoid IL-1 inhibitors severe skin reactions at injection site, bone marrow transplant may be curative @RheumNow #ACR21 Session6S410 L Wilson, DO Cordona https://t.co/eQ1KVDiKKV
Dr. Antoni Chan synovialjoints ( View Tweet)
HSS Study of 136 SLE flares post-vax:
👉100 (74%) w/expected AE (headache/myalgias)
👉11 (8.1%) pts with SLE flare
👉Majority of flares were mild-mod & occurred w/in 1 week of vaccination
👉Most resolved w/in 7 days.
Abst#0896 #ACR21 @rheumnow
https://t.co/e6AP8PPRH2
TheDaoIndex KDAO2011 ( View Tweet)
Dr. Katie Liao presented an observational study comparing SLE pts who were Ro neg (n=208) vs Ro pos (n=185).
More of the (+)Ro pts had:
⬆️Adjusted mean SLEDIA >4
⬆️Proteinuria
⬆️Neutropenia,+RF, +dsDNA, and low C3 or C4
⬆️Discoid or malar rash
#ACR21 Abst#0323 @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
Fatigue fills us with dread: common, big issue, no proven meds, non-pharm Rx hard to access.
Pragmatic RCT in UK, inflamm rheum dx:
usual care v CBT v exercise program
(all remote delivery)
Clinically meaningful benefit - now how to access?
LIFT study #ACR21 ABST0462 @RheumNow https://t.co/XsSCzkbcCd
David Liew drdavidliew ( View Tweet)
@JointMD shares his thoughts on IL23, IL17, TNF inh- where/when/how we might use them. @RheumNow #acr21 https://t.co/mVw05iFPhF
TheDaoIndex KDAO2011 ( View Tweet)
Rheumatologists and Health Professionals: Join us tonight for RheumNow's #ACR21 Daily Recap at 7pm Eastern time . Register via the Zoom link below.
https://t.co/MalO30jgo1
Or visit our YouTube channel-RheumNow.
https://t.co/nBUk64XBjU https://t.co/pYEFOM1Q2g
Dr. John Cush RheumNow ( View Tweet)
Distinguishing between #preeclampsia and #lupus nephritis flare in 🤰 #SLE patients is very important because management is different. #rheumatology #medtwitter https://t.co/Dc9ohJQ75L
sheila RHEUMarampa ( View Tweet)
Blurred line btwn RA, preRA & RA prevention which makes interpretation of RCTs problematic. I’ve learned that if pt has RA not meeting criteria, some Rx ⬇️chance of RA over time-MTX, now #Abatacept but was it RA anyway AND what happens when you stop Rx? #ACR21 @RheumNow abst#0505 https://t.co/HwivsITvCQ
Janet Pope Janetbirdope ( View Tweet)
#ACR21 #Aging #CommunityHub @UnaMakris @SattuiSEMD @KWyshamMD
Very engaging discussion on the 5 Ms of aging + how they interconnect:
👉🏻multimorbidity (⬆️ risk)
👉🏻meds (poly pharmacy)
👉🏻mentation (cognitive impairment)
👉🏻mobility and disability
👉🏻what matters most <to patient> https://t.co/mZpk3qQFgz
Elena MyasoedovaMD MyasoedovaElena ( View Tweet)
#ACR21 #Abstr0437 OK, so RTX affects #COVID vaccine but some pts need RTX. Factors predicting response to vaccine:
RA vs AAV/IIM
Higher IgG
Longer time-to-RTX
Lower RTX courses Number.
Prediction Calculator is developed but need ext. validation #RheumNow https://t.co/iXSaGQ76hS https://t.co/WQAV3GRPBz
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)