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Consequences of TNF inhibition (3.18.2022)
This week we're going to talk about the downside of TNF inhibitors, a few interesting observations in gout, and yes, kids do get COVID. We're also going to preview what's coming in April (hint: it's about PsA). This and more as Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.
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Heterogeneous pathology leads to heterogeneous response to treatment!
Synovium plasma gene expression🤓
Precision and rheumatology!
Ernest Choy @RheumNow #Rn12022 https://t.co/E2j2oD3RaA
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Precision medicine in RA. Synovial biopsy and synovial molecular signature can predict radiographic progression
@RheumNow #RNL2022 https://t.co/7WPGVhRMD5
Robert B Chao, MD doctorRBC ( View Tweet)
Not bacteria it self, the metabolic changes ( heat map) predict response to treatment! Very interesting 🤓.
NSAIDS change the microbiota😲, didn't see that coming !
@RheumNow Ernest Chiy #Rnl2022 https://t.co/QQoubmVRsn
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Dr. Ernest Choy on how gut microbiome can affect RA prognosis and treatment
Our gut microbiota can be changed by diet and medications (NSAIDs)
@RheumNow #RNL2022 https://t.co/Cp19kG3z8D
Robert B Chao, MD doctorRBC ( View Tweet)
3 different Pathotypes at level of synovium and treatment decision!
Sunovium signature, identify signature for response to treatment
▶️ CXCL13 IL 6
▶️ ICAM TNF
@RheumNow Ernest Choy #Rnl2022 https://t.co/252fYM1PnY
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Is it really seronegative RA!!!!
Happening now. #RnI2022 @RheumNow https://t.co/R3UTYuZRvJ
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
“best laid plans of mice and men oft go astray”.
Dr. Cush giving his opening remarks and pod at #Rnl2022 https://t.co/o9lenN1Dkd
Dr. John Cush RheumNow ( View Tweet)
Welcome to #RNL2022 !
Not only are we in-person in Texas, we have people online from all over the US and Canada to New Zealand and Japan!
Dr. John Cush RheumNow ( View Tweet)
RheumNow Live is kicking off with a pod on Rheumatoid Arthritis - Future Improvements. Dr. Cush will lead the first presentation on Treatment Choices in Refractory RA. #RNL2022 https://t.co/H3RbDPZxM1
Dr. John Cush RheumNow ( View Tweet)
RheumNow Live is HERE. Welcome everyone! What pod are you looking forward to the most?
Anyone out there who is still on the fence--virtual registration is still open. Join us!
https://t.co/3wKgCKqvfD
#RNL2022 https://t.co/W2hUpZ2Y8N
Links:
Dr. John Cush RheumNow ( View Tweet)
Seropositivity Linked to Bronchiectasis in Rheumatoid Arthritis
Bronchiectasis in rheumatoid arthritis-associated (RA-BR) is uncommon, is unrelated to interstitial lung disease (ILD), but like ILD can substantially impact RA outcomes.
https://t.co/xm8HWJkI5C https://t.co/JztHlzGw65
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Dr. John Cush RheumNow ( View Tweet)
Disappointment Behind Acute Gout Hospitalizations
https://t.co/Hd1g5Kvwwr https://t.co/jYFVVOQOZX
Links:
Dr. John Cush RheumNow ( View Tweet)
Environmental Pollutants Ups Autoimmune Disease Risk
An Italian environmental study shows that air pollution increases the risk of autoimmune diseases, in particular rheumatoid arthritis, CTDs and inflammatory bowel diseases (IBD).
https://t.co/LVCn8zgdpG https://t.co/wzi2GzSmGY
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Dr. John Cush RheumNow ( View Tweet)
Medscapes 2022 Physician Suicide report. Sadly 10% of MDs have considered suicide. Highest in pathology (13%), surgery (12%), oncology (12%), ID (11%), EM(11%). LOWEST in Rheumatology (5%), nephrology (2%) https://t.co/ER8kNfcPEh https://t.co/cWQobpIO97
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Dr. John Cush RheumNow ( View Tweet)
Happy Match Day to all newly matched doctors! We can't wait to see who becomes a rheumatologist in a few years. Enjoy your residency and celebrate your amazing accomplishment today! https://t.co/Yuhu7ksmog
Dr. John Cush RheumNow ( View Tweet)
Among 98 women with axSpA, there were 335 pregnancies & 279 live births - 52% uncomplicated and 48% complicated (13%) multiple complications. axSpA had more Preterm birth (13 vs 5%), pre-eclampsia (7 vs 3%), Low birth Wt (8 vs 3%) https://t.co/i43HKduAgu https://t.co/XHbtH9YMrt
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Dr. John Cush RheumNow ( View Tweet)
Baricitinib has been studied in 15 relapsing GCA pts - prospective, open-label, BARI 4 mg/d w/ GC taper. 14/15 completed 52 wks; 13/15 went into remission and d/c steroids. There was 1 Bari D/C for adverse event & 1 pt w/ serious AE. 1 pt relapsed. https://t.co/J5bjdPAFdm https://t.co/LsuSVP8L0R
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Dr. John Cush RheumNow ( View Tweet)
Psoriasis RCT studied ADA+MTX (31) vs ADA (30); after 12 mos, a (non-significant) better drug survival w/ ADA-MTX (74 vs 59%; p=0.15). Also favoring, but not signif was PASI 75 (58 vs 37%). Fewer anti-ADA Abs seen w/ ADA-MTX (23 vs 60%; p<0.01) https://t.co/9CAQrpl6hU https://t.co/mr0ZaJ9mbW
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Dr. John Cush RheumNow ( View Tweet)
Frailty: a decline in the physiologic reserve & function of several systems, leading to increased vulnerability and adverse health outcomes. Not just age; increased in RA (33%) more than AS or PsA. Frailty is dynamic & potentially reversible https://t.co/82hkGKoRxV https://t.co/7d9sycC6S2
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Dr. John Cush RheumNow ( View Tweet)
