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#ACR21 Year in Review: TICOPSA - tight control treat to target in AxSpa does not meet primary endpoint, but favorable secondary outcomes. Was the control group at academic center already receiving good tight control? @Rheumnow
Eric Dein ericdeinmd ( View Tweet)
#ACR21 #ACRbest @RheumNow
Abst#0366 by Garrido-Cumbrera et al. looked at shows that three out of four European axSpA patients have difficulty in finding a job.
swethaann23 swethaann23 ( View Tweet)
T2T in AxSpA? ASDAS-qCRP & ASDAS-CRP showed an almost perfect agreement w/ regard to dz activity categories (96%.) Quick ASDAS-qCRP can be used in real time to make clinical decisions. Abs 0374 #ACR21 #RheumNow @RheumNow https://t.co/opOyedQUaZ https://t.co/aeUEsW9HsX
Dr. Rachel Tate uptoTate ( View Tweet)
Biologic dose tapering in #axialspondyloarthritis in 52% of patients if criteria are met (BASDAI)< 40, physician global score< 40 and no signs of disease activity the previous year, escalation to previous dose if there is a flare @RheumNow #ACR21 Abst#0364 https://t.co/4GntJ6jS11
Dr. Antoni Chan synovialjoints ( View Tweet)
Rare co-existence of FMF & axSpA significantly lowered age of axSpA symptom onset. Radiographic changes in FMF+axSpA suggested worse disease. Rate of amyloidosis and hip involvement were higher in FMF+axSpA pts. Abs 0378 #ACR21 #RheumNow @RheumNow https://t.co/lUmn3A90Ob https://t.co/n3kj8GcV1i
Dr. Rachel Tate uptoTate ( View Tweet)
#ACR21 @RheumNow
Abst#0450 Hwang et al. from the PSOAS cohort analyzed 1618 radiographs between 2002-2017
⭐️Higher spinal disease: Male gender; longer disease duration; smoking
⭐️🔼Disease progression 🔼CRP levels
⭐️🔽Disease progression with time-varying TNFI use https://t.co/XsKp28HOxz
swethaann23 swethaann23 ( View Tweet)
AxSpA pts share a gut microbiome signature with Crohn's disease and anterior uveitis pts
⬇️Blautia
⬆️Veillonella and Lactobacillus
⭐️SpA pts uniquely enriched in Collinsella
Abs#0062 #ACR21 @RheumNow #ACRBest
https://t.co/sdlHxNbhr8 https://t.co/r8eG9c9vwa
Robert B Chao, MD doctorRBC ( View Tweet)
Early axSpA DESIR: higher dz activity & worse function independently assoc'd w/ ^ hazard of Work Disability vs SES. Dz severity strong predictor of adverse work outcome despite advanced therapeutic strategies in axSpA. Abs 0381 #ACR21 #RheumNow @RheumNow https://t.co/Lc3yUgXvw6
Dr. Rachel Tate uptoTate ( View Tweet)
Is it time to consider targeting gut microbiome for treatment of AS?
Large study identified:
⭐️Ruminococcus torques associated with FUT2 gene influences risk of developing AS
Abs#0068
https://t.co/E1hL18KZbQ
#ACR21
#ACRBest
@RheumNow
Robert B Chao, MD doctorRBC ( View Tweet)
Possible disease activity biomarkers in axSpA? Neutrophil lymphocyte ratio (NLR) & platelet lymphocyte ratio (PLR) along w/ PROs may be helpful to measure dz activity clinically. More studies needed for proof of concept. Abs 0384 #ACR21 #RheumNow @RheumNow https://t.co/ZXyQHNzqz7 https://t.co/va5fBR9Gnk
Dr. Rachel Tate uptoTate ( View Tweet)
#ACR21 @RheumNow
Abst#0370 by Afinogenova et al.
138 PCP surveyed on Chronic back pain evaluation
▶️58% rarely assess for IBP
▶️40% not comfortable diagnosing AS
▶️70% not comfortable diagnosing axSpA
Contributing to a lack of referral to rheumatology and delay in diagnosis.
swethaann23 swethaann23 ( View Tweet)
Serum IL-22 levels elevated in axSpA pts in Israeli study. Possible independent biomarker for the differentiation of AxSpA from its non-inflammatory mimickers? Possible target for treatment? Further studies needed. Abs 0385 #ACR21 #RheumNow @RheumNow https://t.co/AUwZFJTlnq https://t.co/WSZ2WjW45W
Dr. Rachel Tate uptoTate ( View Tweet)
Also DESIR cohort: male gender & higher education independently assoc'd w/ lower hazard of Sick Leave (SL.) Older age & higher disease activity assoc'd w/ more SL. AxSpA dz activity & SES play roles in SL predictions. Abs 0380 #ACR21 #RheumNow @RheumNow https://t.co/1lRhDAu7Ug https://t.co/RRG6BeUqvs
Dr. Rachel Tate uptoTate ( View Tweet)
Factors that predict trajectories of radiographic progression in #axialspondyloarthritis 4 major patterns in the PSOAS cohort. Male gender, longer disease duration, raised CRP and smoking associated with higher spinal progression @RheumNow #ACR21 Abst#450 https://t.co/PvDE7T0MZp
Dr. Antoni Chan synovialjoints ( View Tweet)
Abst 0450 #ACR21 @RheumNow PSOAS cohort 4 trajectories of radiographic progression in AS: Non-progressors 37%, late-progressors 26%, early-progressors 19%, rapid-progressors 18%.⬆️ disease burden: male, longer disease duration & smoking . ⬆️eCRP=higher disease progression https://t.co/wUdBNzJPy0
Olga Petryna DrPetryna ( View Tweet)
ASRI data: high frequency of pregnancy and fetal complications (miscarriage, c-section, early delivery, NICU admission) in AxSpA pts. We need more studies regarding risks/tx/outcomes/breastfeeding guidance. Abs 0369 #ACR21 #RheumNow @RheumNow https://t.co/4BR2ZPPjyB https://t.co/qyTwtfEMMy
Dr. Rachel Tate uptoTate ( View Tweet)
ASAS-PerSpA worldwide study: axSpA most common SpA from in family hx. Except in Middle Eastern/N. African pts, a FH of axSpA associated w/ +HLA-B27 in axSpA pts. PsO and IBD FH more likely -HLA-B27 . FH of ReA rare. Abs 0368 #ACR21 #RheumNow @RheumNow https://t.co/iHBccAcvLi https://t.co/FCoyVg3MGw
Dr. Rachel Tate uptoTate ( View Tweet)
We should aim for early treatment and good retention in ax-SpA to prevent structural evolution. >12 months of TNFi treatment in the previous 2 years associated w/ ⬇️ radiographic progression of SIJ in r- and nr-axSpA in GESPIC, #Abst0174 @RheumNow #ACR21 https://t.co/2V1q4dUwFO https://t.co/lxQU4zAP1I
Aurelie Najm AurelieRheumo ( View Tweet)
Cluster analysis in axSpA pts classified 2 groups (predominantly axial vs peripheral dz) and showed lower TNFi drug survival rates in those with prominent extra-axial manifestations. Abs 0365 #ACR21 #RheumNow @RheumNow https://t.co/ArgQ7mNqeD https://t.co/XqF7rPneMV
Dr. Rachel Tate uptoTate ( View Tweet)
3/4 axSpA EMAS pts had/perceived to have employment challenge. Poor physical/mental health, lower education, hx job change due to axSpA associated w/difficulties/perceived difficulties. Earlier dx/rx AND advocacy needed. Abs 0366 #ACR21 #RheumNow @RheumNow https://t.co/dlGhOymxVQ https://t.co/CWD6U1vRE0
Dr. Rachel Tate uptoTate ( View Tweet)
