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ICYMI: New Laboratory Insights for the ANA+ Consult

Jack Cush, MD

A new study suggests that use of ELISA assays for CXCL-10 and IFN-α can predict which ANA+ individuals may progress to developing a systemic autoimmune rheumatic disease (SARD).

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GI, microbiome, bacteria

Gut Microbiome Alterations in Lupus Patients

EureAlert!

Recurrent bouts of systemic lupus erythematosus, marked by the body’s immune system attack of its own tissues, closely tracked with measurable upticks in growth in the gut of a certain species of bacteria.

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What is Colchicine Worth? (6.23.2023)

Jack Cush, MD

Dr. Jack Cush reviews the news and reports from the past week on RheumNow.com. This week a new colchicine FDA approval, rising rate of IgG4 related disease and what's the safest biologic?

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Higher Genetic Loads Linked to Worse Systemic Lupus

Jack Cush, MD

A Korean study of a large systemic lupus erythematosus (SLE) cohort shows by genomic analysis, that higher weighted genetic risk scores (wGRS) is associated with earlier SLE onset, higher anti–Sm antibody positivity, lupus nephritis and more diverse lupus manifestations.

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EULAR 2023 Notes from Milan (6.09.2023)

Jack Cush, MD

Dr. Jack Cush reviews highlight abstracts and sessions - covering lupus, RA, gout, Still's disease, safety data, AI in medicine and more - from last week's EULAR 2023 Congress held in Milan, Italy.

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A step change towards self-empowerment for people living with SLE

Md Yuzaiful Md Yusof, MRCP(UK), PhD

In my focus group consisting of people living with SLE and their carers, one of the keys issues raised by them was pertaining to poor reliable information about their condition. At the 2023 EULAR Congress in Milan, I learned about the wide scale dissemination and international launch of Lupus100.org project.

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RT @Janetbirdope : #Top #EULAR learnings #SLE #recommendations 1 Limit #prednisone 2 use #biologics early if poor prognosis 3 #lupus #nephritis - treat early with #belimumab or #voclosporin and more Rx in #RCTs #gamechanger

Dr. John Cush RheumNow ( View Tweet)

Gut Microbiome Alterations in Lupus Patients Recurrent bouts of systemic lupus erythematosus, marked by the body’s immune system attack of its own tissues, closely tracked with measurable upticks in growth in the gut of a certain species of bacteria. https://t.co/eGk4EQsVES https://t.co/PiFKxJWD13

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Dr. John Cush RheumNow ( View Tweet)
Why Patients Don't Take Medicines This report examines the characteristics of adults aged 18–64 who took prescription medication in the past 12 months and did not take medication as prescribed due to cost. https://t.co/zuPgMjKYbh https://t.co/62cG9LDYWi

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Dr. John Cush RheumNow ( View Tweet)
EULAR 2023 Lupus Highlights https://t.co/CGybJRjDDK https://t.co/2kkB1hX2J5

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Dr. John Cush RheumNow ( View Tweet)
Watch: De Novo Renal Nephritis Flares During Belimumab Trials Drs. Yuz Yusof and Iaonnis Parodis discuss abstract POS1156 at EULAR 2023 in Milan, Italy. https://t.co/XLzDF2VZ7Q https://t.co/iE16Ag3Rsu

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Dr. John Cush RheumNow ( View Tweet)
Rheums! Have a rheumatology question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. https://t.co/3atPdJwb1m https://t.co/MKbgzEi9pd

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Dr. John Cush RheumNow ( View Tweet)
Higher Genetic Loads Linked to Worse Systemic Lupus A study of a large SLE cohort shows by genomic analysis, that higher wGRS is associated with earlier SLE onset, higher anti–Sm antibody positivity, lupus nephritis and more diverse lupus manifestations. https://t.co/L8ZZEgcfNM https://t.co/elwDtDuSjP

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Dr. John Cush RheumNow ( View Tweet)
We should put the CART before the T in SLE! Dr. Janet Pope ( @Janetbirdope ) reports from EULAR 2023 in Milan, Italy. https://t.co/HwYphsg3ad https://t.co/Ghu2M6yaFn

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Dr. John Cush RheumNow ( View Tweet)
Novel drug in development, LY3361237, is a BTLA (B & T lymphocyte attenuator) agonistic antibody to treat autoimmune Dz (eg SLE) - augments immune responses by activating checkpoint inhibitory receptors (CIRs). https://t.co/3iYq9UwHww https://t.co/RwrhqRO8cm https://t.co/tl8qVIXqjc

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Dr. John Cush RheumNow ( View Tweet)
RheumNow Eular2023 Coverage - SLE Panel Discussion https://t.co/pLWOqZo2aw https://t.co/itAOjgmMTl

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Dr. John Cush RheumNow ( View Tweet)
A step change towards self-empowerment for people living with SLE As I reflect on my research journey, I recall several issues that still need to be addressed in the management of SLE. https://t.co/ElunbUgSGF https://t.co/YmA1YWPxVP

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Dr. John Cush RheumNow ( View Tweet)
SLE Trial: Dual BTK JAK Blockade compared Upadacitinib Monotherapy Dr. Yuz Yusof discusses abstract OP0139 presented at EULAR 2023 in Milan, Italy. https://t.co/os1tyiDnuT https://t.co/G0owdGek7f

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Dr. John Cush RheumNow ( View Tweet)
Efficacy and Safety of Baricitinib in Lupus Nephritis Dr. Yuz Yusof discusses abstract OP0053 presented at EULAR 2023 in Milan, Italy. https://t.co/ebQ5RwG2po @Yuz6Yusof https://t.co/mUp7OXVK9K

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Dr. John Cush RheumNow ( View Tweet)
#Top #EULAR learnings #SLE #recommendations 1 Limit #prednisone 2 use #biologics early if poor prognosis 3 #lupus #nephritis - treat early with #belimumab or #voclosporin and more Rx in #RCTs #gamechanger https://t.co/JHQHu91tud
Janet Pope Janetbirdope ( View Tweet)
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