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AAOS Clinical Practice Guideline for Knee Osteoarthritis

d Jack Cush, MD

The American Academy of Orthopaedic Surgeons has published their Clinical Practice Guideline for Management of Osteoarthritis of the Knee (Non-Arthroplasty); updating 19 of the 29 evidence-based recommendations and focuses on nonsurgical treatmentss to provide pain and patient function.

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NEJM Clinical Images: Sweets syndrome (Acute Febrile Neutrophilic Dermatosis) - 46F w/ raised painful lesions on extremities. https://t.co/up5PviNDeS)

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ICYMI: New data from the CDC shows that obesity rates have risen in the USA during the pandemic, with 16 states having obesity rates of 35% or higher - that's four more than last year, adding Delaware, Iowa, Ohio and Texas to the list. https://t.co/9nFuea2BOV https://t.co/XmsXmFXhzv

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POETYK PSO-1 and PSO-2 trial results seen at the EADV meeting, studying Tyk2 inhibitor, deucravacitinib vs PBO or apremilast in 666 & 1020 plaque psoriasis pts. Wk 16 PASI 75 higher in DEUC ((59%, 54%) vs Otezla (35%, 40%) vs PBO(13%,9%) https://t.co/qok68Kbb6J

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ASBMR meeting presented results of the ASTEROID trial in osteogenesis imperfecta; Setrusumab, investigational Mab inhibitor of sclerostin, failed to improve radial trabecular BMD (primary endpt), but did improve lumbar/hip/femoral BMD https://t.co/xSDIiffjb7

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RA patients had a higher 30-day rehospitalization than OA after TKR (OR 1.11) and THR (OR, 1.39). While infections, postoperative complications, cardiac did not differ, RA TKR had less VTE, but RA THR had higher VTE risk (OR, 2.41) https://t.co/QlOWngcEnJ

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Stills disease and SpA? 8 pts (5 AOSD, 3 systemic JIA) who met Stills and ASAS criteria, 7/8 developed SpA a meant of 6.2 yrs after Stills Dz. SpA types included 2 peripheral, 3 axial SpA, 4 PsA & 1 SAPHO. Amongst Stills pts 7-10% developed SpA https://t.co/RfeUxE7N7S

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ICYMI: Download today! “Jack of All Subspecialties”—find wherever you get your podcasts. https://t.co/UvQRiLOWsr #RheumNow https://t.co/IiFSBhWCcH

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New data from the CDC shows that obesity rates have risen in the USA during the pandemic, with 16 states having obesity rates of 35% or higher - that's four more than last year, adding Delaware, Iowa, Ohio and Texas to the list. https://t.co/9nFuea2BOV https://t.co/ZjloYnG5oQ

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ICYMI: Can I get the INFLUENZA and COVID Vaccines together? The CDC says: "YES...both vaccines can be given at the same visit, people should follow the recommended schedule for either vaccine.... ideally get a flu vaccine by the end of October." https://t.co/T49zm6kWGE https://t.co/WQMx3XhHmL

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What will happen after COVID - more panic and neglect of public health? An interesting read from The Atlantic. “Progress is always undone; promise, always unfulfilled. “ Is America Prepared for the Pandemic After COVID-19? https://t.co/AA9qIo0DMH

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ICYMI: JAK inhibitors as potential treatment for Juvenile Dermatomyositis: nice review of the biology of JAKi effects and the reports of JAKi success in adults and kids with IIM https://t.co/k3qunsCdBN https://t.co/nyqMo6vh88

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ICYMI: U.S. Preventive Services Task Force (USPSTF) reaffirmed its recommendations that pregnant women at a high risk of preeclampsia should take a daily aspirin regimen at the end of the first trimester https://t.co/DiV7p5YxEd https://t.co/FJu7BxEkkw

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In case you missed it— A longitudinal study from Iceland shows an increasing number of native joint infections (NJI), with iatrogenic, postarthroscopic infections being of particular concern. Read more… https://t.co/n82PpZ7a96 #RheumNow https://t.co/SmOBX0701N

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ICYMI: Biosimilar update: 31 FDA approved biosimilars, but only 60% made it to market. 2015 to 2019, drug spending grew 6.1%, biologic spending grew 14.6%; biologics are 43% of US drug spending. Most biologics at ~30% discount. https://t.co/4paYH8hkUi https://t.co/Ztjp9g3uo3

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In case you missed it: Patients with rheumatoid arthritis (RA) who had a history of cancer did NOT have an increased risk of new or recurrent cancers if treated with biologic therapies, a meta-analysis found. #RheumNow https://t.co/jM9oiRin2M https://t.co/RknVHmZK98

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New podcast available for download! “Jack of All Subspecialties”—find wherever you get your podcasts. https://t.co/UvQRiLOWsr https://t.co/oUqrhXjSJJ

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CDC Advises COVID-19 Vaccines for Pregnant Women https://t.co/cRQx8QdO7F #RheumNow https://t.co/iL6JIEiGFw

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Using EHR data from the UK, the frequency of children and young people with JIA in 2018 was studied. Age standardised incidence rate =5.61 per 100 000; prevalence rate=43.5 per 100 000. 5-yr incidence rates did not change over time. https://t.co/mwmf5nktkF

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A placebo controlled RCT of canakinumab in 31 Adult Stills pts with arthritis showed responders (by DAS28) had signif reductions in calprotectin, IL-1RA, IL-18, IL-at wk 4. Unfortunately: didnt look at fever, rash, serositis, etc. https://t.co/p4Fohos2iU

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