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High Comorbidity Rates with Inclusion Body Myositis

d Jack Cush, MD

Inclusion body myositis (IBM) patients tend to be older than those with idiopathic inflammatory myositis (IIM), but the scope of disease beyond their myositis is not appreciated.

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Worrisome Maternal Mortality with COVID-19 Infection

d Jack Cush, MD

Maternal and fetal outcomes during the COVID-19 pandemic have not been well studied; yet a new retrospective study from Mexico indicates that during the pandemic maternal mortality increased by nearly 57%, with COVID-19 as the cause in 23% of cases.

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MMWR reports real world vax efficacy in 3,689 adults (21 states) found better results w/ Moderna (93%) than Pfizer (88%) than Janssen (71%). 2 dose mRNA vaccines were more effective than 1 dose Janssen COVID vaccine https://t.co/phmPdB9dTW

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Lupus Research Alliance has awarded $3 million Global Team Science Awards to Drs Virginia Pascual (Weill Cornell Med Schoo) and Ignacio Sanz (Emory Univ Medial School) for their proposed collaborative, translational lupus projects. https://t.co/ecMlHiZfwe

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Maker Trade name Generic PFIZER Comirnaty Pfizer-BioNTech COVID-19 Vaccine FDA approved MODERNA Spikevax Moderna COVID-19 Vaccine - EUA currently J&J (pending) Janssen COVID-19 Vaccine- EUA currently https://t.co/MM7XiSCczl

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Interested in becoming a rheumatologist? It’s interview season! Dr. Kathryn Dao (@KDAO2011 ) shares tips for the interviewer AND the candidate. #RheumNow #RheumTwitter https://t.co/eWQs9CwqSm https://t.co/7FrkCWoAe8

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Addendum: Other conditions w/ a 1.2-2 fold higher risk of COVID death (admission) were CKD, hematologic cancer, epilepsy, COPD, CVD, stroke, atrial fibrillation, CHF, thromboembolism, PVD, type 2 diabetes. https://t.co/bbDsb1zLhX

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Addendum: COVID deaths increased w/ age, deprivation, male, Indian & Pakistanis. Highest risk w/ Down’s syndr (HR 12.7), renal transplant (8.1), sickle cell (7.7), Nursing home (4.1), chemotherapy (4.3), HIV/AIDS (3.3), liver cirrhosis (3), CNS dz (2.6) https://t.co/bbDsb1zLhX

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Breakthrough infections from UK QResarch database: Among 6.95 million vaccinated, 74.1% recv two vaccine doses, there were 2031 covid-19 deaths & 1929 hosp admissions; ~4.0% deaths & admissions were >14 days after 2nd dose https://t.co/bbDsb1zLhX

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Have you seen this download? How to define difficult RA--download now. https://t.co/6WGMEieHvK https://t.co/yYZdfyUQu0

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Claims case-controlled study shows statin use does not increase the risk of #RA - 32,726 RA and matched controls ; statin use (34 vs 32%) slightly increased RA risk (OR 1.12, 1.06–1.18), but signif lost after correcting for hyperlipidemia https://t.co/EcTlyE1MPx

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Analysis of existing #COVID data - as of 7/15/21, 114.9 million adults infected with COVID-19 in US. Overall population immunity (Infx+vax) is 62%, highest in adults >65yrs (77.2%); lowest in children <12 yrs (17.9%) https://t.co/EYiBUaQBLY

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"In medical school, they spend days teaching people to operate on lungs, and no time at all helping young doctors learn how to get their patients to stop smoking and get vaccinated." - Seth Godin https://t.co/YIk0O0kDTB

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Patients with systemic lupus erythematosus (SLE) had two to four times higher risk for serious infection requiring hospitalization, a nationwide Swedish study found. https://t.co/ilkqTtZjVL #RheumNow https://t.co/hzcqlNUF66

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ICYMI: American College of OBs & GYNS and the Society for Maternal-Fetal Medicine both enthusiastically endorse COVID Vaccination of pregnant women, given the delta variant, low vax rates in Preg women and poor COVID outcomes in preg. https://t.co/AmP5eOEgr3 #RheumNow https://t.co/wXeT1KDCrJ

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ICYMI: Gitelman syndrome (GS) is common salt-wasting genetic tubulopathy causing hypokalaemia and hypomagnesemia. Chondrocalcinosis (CC) is a frequent feature of GS. Study of 57 GS pts - 79% had CC, esp in Cx spine, Knee & wrist. https://t.co/ctEAQq1zzL #RheumNow

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In case you missed it… Breakthrough COVID infection. Breakthrough brilliance in a KOL A must read from Len Calabrese https://t.co/2Ljzau5nBG #RheumNow

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We've got a new podcast available for download! Dr Jack Cush reviews the news and journal reports and takes cases and questions from rheumatologists. https://t.co/ErJJ5XL8NA #RheumTwitter #RheumNow #medtwitter https://t.co/tqyVNyNYa4

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ICYMI: Population study shows risk of H. Zoster in adults to be high among bDMARD and CTX, also increased w/ AZA and HCQ but not MTX SSZ or LEF users. Data from 254065, 1,826311 Pt-Yrs F/U, 6295 new DMARD users, 17024 incident HZ https://t.co/1TeOAWN9LB #RheumNow

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ICYMI: Probenecid, an OAT3 inhibitor, has inhibitory effects on RNA viruses (influenza, RSV) & decreases ACE2 expression. May have utility in COVID-19 as it was shown to inhibit SARS-CoV-2 replication in animal models https://t.co/MClSjpqpSa #RheumNow

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