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Safety and Tolerability of Subcutaneous Methotrexate

d Jack Cush, MD

A large, single-rheumatology center analysis of oral and subcutaneous (SC) methotrexate (MTX) use in daily clinical practice suggests that SC MTX has fewer drug discontinuations and is better tolerated compared to other DMARD therapies.

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RheumNow Podcast – Saphnelo (Anifrolumab) Approved for Lupus (8.6.2021)

d Jack Cush, MD

It was a banner week at the FDA; a new drug approval you should know about; a lot of information about pregnancy and safety; and an interesting case plus a question from one of our readers submitted via Back Talk. This and more in this week's podcast. Let's dive in.

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Lumbar Spine Decompression Alone is Superior to Decompression with Fusion

d Jack Cush, MD

The NEJM has published a multicenter study wherein patients with surgical lumbar spinal stenosis and degenerative spondylolisthesis were found to fair equally well (noninferior if treated with decompression surgery alone compared to decompression with instrumented fusion.

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Delays in Joint Replacement as JIA Patients Reach Adulthood

d Jack Cush, MD

A retrospective cohort study examined the need for joint replacement surgery in juvenile idiopathic arthritis (JIA) and showed there has been a trend to delay arthroplasty over time. The JIA category, year of implant, and presence of complications significantly affected implant survivorship.

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Skin Involvement with HMGCR Necrotizing Myositis

d Jack Cush, MD

The Journal of Autoimmunity reports that anti-HMRCR antibody positive, necrotizing myositis patients frequently have cutaneous lesions, moreso than previously reported.

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Rheumatic Flares Uncommon After COVID Vax

d MedPage Today

Post-vaccination disease flares were uncommon among patients with rheumatic and musculoskeletal diseases who were inoculated against COVID-19, researchers found.

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Multimorbidity Impairs Responses in Rheumatoid Arthritis

d Jack Cush, MD

A retrospective analysis of the ACR RISE registry shows that multimorbidity is not only common in patients with active rheumatoid arthritis (RA), but also impacts treatment choices and outcomes.

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Clinical characteristics and outcomes of COVID-19 breakthrough infections among vaccinated patients with systemic autoimmune rheumatic diseases https://t.co/xftj12BgzX #medRxiv

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medRxiv medrxivpreprint ( View Tweet)

The Israeli data for increased mRNA-vaccination breakthrough infections and "waning immunity" is finally available https://t.co/9j73Q7L7Nn h/t @Aiims1742 Overall 2X risk, no statistical significant difference between age groups, but trend of increase w/ age https://t.co/D4IpFm6Ydl

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Eric Topol EricTopol ( View Tweet)
D-penicillamine Adverse events reported to FDA (1970-2020): dystonia (OR 20.52), drug hypersensitivity (OR 5.42), pancytopenia (OR 10.2), joint swelling (OR 9.07), Renal (OR 6.68), dysphagia (OR 5.05), CHF (OR 4.04), edema (OR: 3.77) https://t.co/8lmYiJo2Tz

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Dr. John Cush RheumNow ( View Tweet)

Serum adipokine CTRP9 levels may predict severe lung dz in Systemic Sclerosis (SSc-ILD): Retrospective longitudinal Registry/Biorepository study; 110 SSc pts - 31% had elevated CTRP9 assoc w/ lower FVC. Low CTRP9 assoc w/ FVC Stability. https://t.co/AY4U12kwPr

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Dr. John Cush RheumNow ( View Tweet)

54-year-old man with several weeks of diffuse abdominal pain/tenderness. Feet and hands showed diffuse petechia. CT scan - occult ileocecal perforation and segmented small bowel wall thickening in Intestinal skip lesions. Most likely diagnosis?https://t.co/DaeiC1gqln

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Dr. John Cush RheumNow ( View Tweet)

A retrospective analysis of the ACR RISE registry shows that multimorbidity is not only common in patients with active rheumatoid arthritis (RA), but also impacts treatment choices and outcomes. https://t.co/72Lcqxjoly

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Dr. John Cush RheumNow ( View Tweet)

Retrospective study of 80 kids w/ systemic JIA - 12 pts changed anakinra to cananinumab & continued w/ clinical inactive Dz (CID). 68 active sJIA Rx w/ CAN: 57% CID off GCs at 6 mos & 64% at 12 mos. NonResponse predicted by #active jts ≥5, hx of MAS https://t.co/QkmqzRrjp6

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Dr. John Cush RheumNow ( View Tweet)

CRESS – A New Composite Measure for Primary Sjögren's Syndrome https://t.co/7tvjBvP3g4

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Dr. John Cush RheumNow ( View Tweet)

A prospective, longitudinal study of the cognitive development of children born to mothers with rheumatoid arthritis (RA) demonstrates normal development as measured by comparative school test scores. https://t.co/6Dfdnin1aI

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Dr. John Cush RheumNow ( View Tweet)

Cohort study of 66 874 postmenopausal women older than 50 years finds fracture to predict a greater risk of subsequent fracture (regardless whether 1st fracture was traumatic or nontraumatic). All such pts need OP assessments https://t.co/EQtDdZb8Vz

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Dr. John Cush RheumNow ( View Tweet)

Systematic review of Kawasaki Dz treatment (4 RCTs, 456 pts) shows MAb & anti-cytokine biologic use does not reduce Coronary artery abnormalities (RR 0.93; [95%CI], 0.65 to 1.32) vs IVIG, but Abs did reduce Rx resistence (RR 0.60) https://t.co/FJkQfxCkjB

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Dr. John Cush RheumNow ( View Tweet)

Congrats to Deborah Veis, MD, PhD, appointed to be the next editor-in-chief of Journal of Bone & Mineral Research Plus (JBMR Plus). Dr Veis is a professor in the Division of Bone & Mineral Diseases at Washington University School of Medicine https://t.co/9aOibSdhqC

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Dr. John Cush RheumNow ( View Tweet)

JRheum review: 40–50% of psoriasis pts have psoriatic nail disease NP). NP is an important predictor of enthesitis, which is associated with the early stages of PsA https://t.co/sEuih3CSgX

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Dr. John Cush RheumNow ( View Tweet)

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