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Non-Serious Infection Risk with Biologics in RA

d Jack Cush, MD

Nonserious infections (NSI) comprise the bulk of all infections seen with biologic therapies; new data from British Society for Rheumatology Biologics Register for Rheumatoid Arthritis shows that while NSI are more common than serious infections, the predictors of NSI are the same as serious infections.

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What Factors Predict RA in First-Degree Relatives?

d MedPage Today

Among a cohort of first-degree relatives of patients with rheumatoid arthritis (RA), certain patient characteristics, as well as symptoms, helped predict a possible increased risk for developing the disease, U.K. researchers reported.

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Booster Shots for Rheumatology Patients on Immunosuppressive Medications

d ACR Press Release

ATLANTA – The CDC's Advisory Committee on Immunization Practices today recommended that rheumatology patients being actively treated with high-dose corticosteroids, alkylating agents, antimetabolites, TNF blockers, and other biologic agents that are immunosuppressive or immunomodulatory receive a third dose of the Pfizer-BioNTech or Moderna mRNA COVID-19 vaccines.

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Sporadic reports of anakinra use in COVID-19 infection has hinted is potential; now a metanalysis shows that the use of anakinra may reduce the mortality risk in patients admitted to hospital with moderate to severe COVID-19 pneumonia. https://t.co/VBxg9fQmt0 https://t.co/ARX2C0WRJ1

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Dr. John Cush RheumNow ( View Tweet)
Analysis of 7815 RA patients (female, 85%) w/ 340 H. Zoster events (309 pts). HZ rates were lower in men vs women 8.5 vs 11 HZ/1000 Pt-Yrs. Zoser Risk factors: incr HAQ (OR 1.51), MTX use (1.58), and biologic use (1.88) https://t.co/p0MTlwgJ8g Conclusions

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Dr. John Cush RheumNow ( View Tweet)

Among a cohort of first-degree relatives of patients with rheumatoid arthritis (RA), certain patient characteristics, as well as symptoms, helped predict a possible increased risk for developing the disease, U.K. researchers reported. https://t.co/7geaJDO8O8 https://t.co/opIu4gXxin

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Dr. John Cush RheumNow ( View Tweet)
https://t.co/lRr1EsoADU EULAR 2021: Still’s Disease Highlights Sponsored by Novartis Medical Affairs Listen to a discussion of medical experts discuss insights from independently selected abstracts in Still’s disease.

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Dr. John Cush RheumNow ( View Tweet)

16 Pts on mech ventilation for SARS-CoV-2- induced ARDS with hyperinflammation were treated with ruxolitinib plus standard care - 13/16 survived 28 days. Better outcomes seen w/ RUX and Lymph-neutrophil ration > 0.07. https://t.co/4O2Y5swE0x

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Dr. John Cush RheumNow ( View Tweet)

In the week ending 8/12: 👧🏽121,427 pediatric #COVID19 cases (14.4% of all cases, 49 states) 🏥452 pediatric hospitalizations (24 states reporting) 💀7 pediatric deaths (43 states reporting) One death is too many.

Shematologist, MD acweyand ( View Tweet)

Here is a fairly obvious piece of advice: If a patient presents with a diagnosis (self-made) rather than a symptom, work hard to clarify the symptom itself. You usually make the same diagnosis but not always...

Adam Cifu adamcifu ( View Tweet)

Scottish study of 78 000 veterans shows no association between military service and future OA knee/hip. 78K Vets compared to 253K non-Vets shows Vets with a lower risk of THR (HR 0.87), but not TKR (HR 1.02). https://t.co/JU7Q80qji1

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Dr. John Cush RheumNow ( View Tweet)

Metanalysis of Colchicine in oronary artery disease (CAD) (13RCTs, n=13125), colchicine signif. reduces the risk of MI (OR 0.64) & CVA/TIA (OR 0.50), but has a higher rate of GI upset with no influence on all‐cause mortality (OR 0.96) https://t.co/CRDUFsc6lG

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Dr. John Cush RheumNow ( View Tweet)

Osteoarthritis vs. Rheumatoid Arthritis https://t.co/qvVEcKqNAM https://t.co/WDyIZxoL7v

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Dr. John Cush RheumNow ( View Tweet)
Watch Now: The Sentinel Joint: Dr. Kathryn Dao ( @KDAO2011 ) reviews abstract POS0385 presented at the virtual EULAR 2021 meeting. https://t.co/H3DcSHQWHr https://t.co/f7LDNz6oyL

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Dr. John Cush RheumNow ( View Tweet)
Popular on RheumNow https://t.co/BZsl8a6ArW The U.S. Food and Drug Administration (FDA) has approved Octagam 10% [Immune Globulin Intravenous (Human)], as the first and only intravenous immunoglobulin (IVIg) formulation to be approved for adult dermatomyositis (DM). https://t.co/RNFsJadUZx

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Dr. John Cush RheumNow ( View Tweet)
Popular post-- AstraZeneca announced that anifrolumab (Saphnelo or anifrolumab-fnia) was approved by the the FDA for that treatment of adult patients with moderate to severe systemic lupus erythematosus (SLE) who are receiving standard therapy. https://t.co/22HVA32IAh https://t.co/CGkBW80un4

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Dr. John Cush RheumNow ( View Tweet)
FDA has approved Xywav - gamma-hydroxybutyrate (GHB) for “idiopathic hypersomnia,” (people sleep 9+hrs/, yet never feel rested). GHB prev approved for narcolepsy https://t.co/38MBpmOAAA https://t.co/5pLLghCYtp

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Dr. John Cush RheumNow ( View Tweet)

A Top Tweet this Week: A large cohort study of rheumatoid arthritis (RA) patients shows that regular tea consumption was associated with a lower risk of RA. https://t.co/ODTs7PdGTN https://t.co/69mi8IlBdj

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Dr. John Cush RheumNow ( View Tweet)
In case you missed it… TB rarely causes arthritis; accounts for 1-5% of all TB (10-30% of pulmonary TB) cases. May present as mono/oligoarthritis, tenosynovitis, dactylitis, Spondylitis (Potts disease), reactive arthritis (Poncets dz) or polyarthritis. https://t.co/RpMrRLQbEa

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Dr. John Cush RheumNow ( View Tweet)

Dont make a point, make a difference - Seth Godin https://t.co/kJE3EGCY83

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Dr. John Cush RheumNow ( View Tweet)

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