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ACR 2024 - Day 1 Report

Jack Cush, MD

ACR Convergence 2024 opened today with a full slate of presentations, posters and specialty meetings.  The meeting began with a flip: the plenary sessions started at 9AM and the poster session began at 1030 AM. Below are some of the highlights from day one in Washington, DC.

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figure sitting in top of hourglass

axSpA: Moving the needle in time to diagnosis

Antoni Chan, MD, PhD

The journey to axial spondyloarthritis (axSpA) diagnosis is often prolonged and challenging. Understanding the factors contributing to the delays is important to improve the clinical, psychological, social and economic outcomes. Data from the SPACE cohort (abstract 0566), the ASAS-PerSpA study (abstract 0550) and the US Claims data (abstract 0558), allows us to highlight the barriers to early diagnosis of axSpA and identify opportunities for improving early diagnosis and treatment.

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Abstract 333 showed that in a cohort of patients with IIM-ILD increased age, PH, FVC decline at 1 yr, SOB at 2 years were predictors for mortality and lung transplant ! #ACR24 @RheumNow https://t.co/NgOj7WKeE3

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Gabriela Martinez Zayas, MD MartinezZayasMd ( View Tweet)
Factors associated w/ secukinumab response in PsA? Analysis of 2.7k pt in EuroSpA Associated w/ favorable response ❗️elevated CRP >10 mg/L ❗️fewer prev tx Associated w/ lower response: ❗️smoking ❗️higher patient global score / HAQ @RheumNow #ACR24 Abstr 2325

Brian Jaros, MD Dr_Brian_MD ( View Tweet)

Systematic review & meta-analysis by DrHChaudhary et al @DaoudAnsaam @mmagrey1 showed that males w/ axSpA who were treated with biologics had ⬆️ BASDAI150 response & likely w/ ASDAS low dse activity vs. females w/axSpA Again, effect of gender differences @RheumNow #ACR24 abs599 https://t.co/2DPYC8exES

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sheila RHEUMarampa ( View Tweet)
What is my risk of developing SLE? Abstract 0843 highlights a predictive model that accurately classifies SLE risk using genetics, lifestyle, and environmental factors. Model 3 (genetics + environment + lifestyle) performed the best compared to models 1 and 2. @RheumNow #ACR24 https://t.co/sk9oG0OY3W

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Akhil Sood MD AkhilSoodMD ( View Tweet)
Race of b/tsDMARDs in RA, the “JAK-pot” study. JAKi and TNFi with more rapid early improvement in CDIA, HAQ, and pain compared to ABA or IL-6 inhibitors…..although effects blunted after adjusting for patient and RA characteristics #ACR24 @RheumNow ABST#0501 https://t.co/8M4wX3LAbW

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Jiha Lee JihaRheum ( View Tweet)
How early is early? Data from SPACE cohort included 548 pts with CBP (<2y duration) and different SpA features followed over 2years. -At the end of 2 years, 39% pts were dx with axSpA. -Median time to dx: 35 months. -HLAB27+, sacroilitis on MR and peripheral arthritis were the… https://t.co/AYtJCp8yno https://t.co/VL7KSrpvp9

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Adela Castro AdelaCastro222 ( View Tweet)
Cross-sectional study finds metabolic dysregulation in RA-ILD is indicative of poor prognosis- FGF-21 assoc w. poor survival. Another link btwn CV risk factors, metabolic syndrome & RA? Should we be doing more to manage metabolic risk factors in RA-ILD? Ab0803 #ACR24 @RheumNow

Mrinalini Dey DrMiniDey ( View Tweet)

Medication-assisted weight loss has boomed in recent yrs. How does weight loss affect disease activity & PROs in RMDs? ≥5% weight loss, after taking a med, led to better disease activity & QoL Data may inform RCTs to explore effect of these meds in RMDs Ab0845 #ACR24 @RheumNow

Mrinalini Dey DrMiniDey ( View Tweet)

Don’t miss the “window of opportunity” for aggressive treatment in early RA! with active RA, risk of ILD 6x and RA-related lung disease 4x higher #ACR24 @RheumNow ABST#0802 https://t.co/yxlfInte6A

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Jiha Lee JihaRheum ( View Tweet)
Harkins @DrTrishHarkins et al. 1 year outcomes of 65 PMR patients treated in FTC. 32.7% experienced relapse, 28% still on GCs, 21% on tocilizumab. @RheumNow #ACR24 Abstr#0739 https://t.co/uYBYhPqGQE https://t.co/n9x9BDTPKg

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Richard Conway RichardPAConway ( View Tweet)
#Disparites posters #ACR24 - Analyzed 954 SLE patients - Black and Asian patients had higher severe damage events - Neighborhood disadvantage (ADI) linked to increased severe damage - Older age and comorbidities increased damage risk abst#0362 @rhuemnow

Bella Mehta bella_mehta ( View Tweet)

Disparities posters #ACR24 - Analyzed 10,604 SLE patients - 18.7% in the lowest SES group experienced functional status decline vs. 12.5% in the highest SES group - African American patients and Greater neighborhood deprivation did worse #ACR24 abst#0190 @RheumNow

Bella Mehta bella_mehta ( View Tweet)

More steroid-sparing options for #IgG4RD! Abstract 0775: In pts w/ IgG4: - Inebilizumab (CD19-monoclonal ab) vs placebo associated with reduced risk of flare (HR 0.13; 95% CI 0.06, 0.28) AEs: infections, infusion reactions, lymphopenia #ACR24 @RheumNow https://t.co/Vr5hcd2E7E

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Akhil Sood MD AkhilSoodMD ( View Tweet)

McDermott @jeffsparks et al. SAIL-RA prospective study. 172 early RA patients. RA lund disease in 16%, RA-ILD in 11%. Disease activity strongest predictor RA lung disease, HR 4.89, and RA-ILD, HR 6.17. @RheumNow #ACR24 Abstr#0802 #ACRbest https://t.co/ia0koG64mL https://t.co/U1KdgcUfOy

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Richard Conway RichardPAConway ( View Tweet)
The 2009 ASAS classification criteria did not meet the set targets of 75% sensitivity and 90% specificity in the CLASSIC cohort, indicating the need for revision of these criteria to increase its performance and validity in classification of axSpA. Abst#0820 #ACR24 #ACRBest… https://t.co/lF3QbRUpx3 https://t.co/SHPMpCjizS

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Adela Castro AdelaCastro222 ( View Tweet)
This interesting systematic review showed that the prevalence of ILD was 15% in patients with SLE. This higher than previously reported! #ACR24 @RheumNow https://t.co/O1aZUUL4Ho

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Gabriela Martinez Zayas, MD MartinezZayasMd ( View Tweet)
Researchers developed a digital messaging program to reduce fatigue in SLE - Grounded in social cognitive and self-determination theories - Reviewed 148 messages, refined based on patient feedback - High patient ratings, future will see more of these #ACR24 abst#0362 @RheumNow

Bella Mehta bella_mehta ( View Tweet)

#ACR24 abst#0430 - Analyzed 61 SLE pregnancies - Higher early gestational Mean Arterial Pressure before 20 Weeks linked to increased preeclampsia risk - MAP trends at 8-10 and 17-19 weeks showed highest predictive accuracy for risk prediction @RheumNow https://t.co/37mg0WX43v

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Bella Mehta bella_mehta ( View Tweet)
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