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Don't stop hydroxychloroquine in SLE, even when doing well. Associated with ⬆️flare risk. x2 even when in remission. Abstr#0959 #ACR21 @RheumNow https://t.co/1gGx0V5oxk
Richard Conway RichardPAConway ( View Tweet)
1133 MACE events in Oral Surveillance study - Tofa use in high risk pts had more MACE events than TNFi use. Abstr# 0958 #ACR21 Problems with the gimmish are:
- Older patients, w/ Hi CV Risk
- 50% prednisone use
- Use of TNFi as comparator (effective at lowering CV risk) https://t.co/lzIyhgzvRe
Dr. John Cush RheumNow ( View Tweet)
The strawberry🍓gums of granulomatosis with polyangiitis! (Note: not always so florid)
@RheumNow #ACR21 #RheumTwitter #MedTwitter https://t.co/qDfGJ5JeWz
sheila RHEUMarampa ( View Tweet)
⭐️IR for MACE, MI, non-fatal MI numerically ⬆️ in Tofa vs. TNFi
⭐️HR for MACE/MI/stroke >1 for Tofa vs. TNFi
⭐️Risk factors: Smoking, ASA use, Age>65, men
⭐️Pts without risk factors, IR for MACE were similar
Abs#958
#ACR21 @RheumNow #ACRBest
https://t.co/xA3aGu5Sqi https://t.co/VnPHBhrmdx
Robert B Chao, MD doctorRBC ( View Tweet)
okay, so let's look at the #ACR21 plenary as we go
so a reminder - FDA-mandated phase 3b/4 safety endpoint study
specifically looking at patients >50yo with at least one other CV risk factor
today we're looking at MACE: that's CV death (excl PE), MI, stroke
ABST0958 @RheumNow https://t.co/9U8Sahb9Q7
David Liew drdavidliew ( View Tweet)
Vitamin D ⬇️incident autoimmune diseases & so do fatty acids but latter is not stat signif. 25k older adults with factorial design, no interaction. ? Buy vit D stock @RheumNow #ACR21 #ACRBest VITAL trial abst#0957 https://t.co/Qk3VwNOZie
Janet Pope Janetbirdope ( View Tweet)
Can vit D, omega-3 fatty acids prevent autoimmune dx development, even in non-deficient people?
(some plausibility, no other meds can)
vit D *might* have an effect, esp post-2y
cautious interest seems okay!
extension worth looking at
VITAL trial add-on #ACR21 ABST0957 @RheumNow https://t.co/H5aF8Vl79u
David Liew drdavidliew ( View Tweet)
Can vit D and omega3 prevent autoimmune dz?
25,871 adult pts randomized:vit D 2000 IU daily, omega 3 (1 g/d), combo, PCB and followed 5 yrs
Vit D & combo showed statistical sig over time, omega3 showed a favorable trend
Abst#0957 #Plenary #ACRbest @rheumnow https://t.co/moMCm9IJmO
TheDaoIndex KDAO2011 ( View Tweet)
Take your supplements 🐠 fish oil and Vit D! VITAL RCT presented by @karen_kc123 shows Vit D +/-n-3 fatty acid ⬇️ incidence of AID compared to PBO.
Promising although AID were self reported!
@RheumNow #ACR21 #Abst0957 https://t.co/xdEdKuwXci
#ACRBest https://t.co/zWrr9oC7F5
Aurelie Najm AurelieRheumo ( View Tweet)
Interesting study with Dr. Julia Manasson on gut and skin microbiome in monozygotic twins discordant for psoriatic disease. (red = Psoriatic). Gut ruminococcus bromii virtually absent in psoriatic pts. Eager to see further studies!
#ACR21 Abst#0944 @RheumNow https://t.co/zrZPBAjh5p
Pedro Castillo _Castillo_Pedro ( View Tweet)
Clinical Pearl at @ACR21
Is patchy tongue erythema + angular chelitis representative of Sjogren's or oral candidiasis?
Beware: Oral candiasis is a mimic of Sjogren's tongue.
Differentiate by asking if burning of tongue. If so, not Sjogren's -- start PO antifungal!
@RheumNow https://t.co/FbdiX8PFKV
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
I honestly find Vit D literature confusing! VITAL RCT omega3 and vit D in preventing autoimmune diseases. They seems to work?🧐The confidence intervals just shy of 1.00...I am still skeptical..but keeping vit D normal doesnt hurt I guess....#ACR21 @rheumnow abst#0957 https://t.co/QFcz2zK4Ic
Bella Mehta bella_mehta ( View Tweet)
Physician global score was the strongest predictor of future flares in AS patients with TNFi dose tapering. 29 (27%) flared at 2/3 of standard
dose, 21 (20%) at 1/2 dose, 29 (27%) at 1/3 dose and 27 (25%) after discontinuation @RheumNow #ACR21 Abst#0929 https://t.co/pIzLgexe3k https://t.co/UM9cGLiYl7
Dr. Antoni Chan synovialjoints ( View Tweet)
Abst#0946 shows a distinct lipid profile in RA vs PsA synovium + synovial fluid.
Sphingomyelins & phosphatidyl-cholines/ethanolamines had the greatest separation power to classify RA + PsA samples. These lipid markers may have clinical utility if validated.
#ACR21 @Rheumnow https://t.co/ktKRypTtlE
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
SKIPPAIN results: Spinal pain response after 8 weeks of SEC showed notable differences between HLA-B27 subgroups. Can subtype pre-determine tx efficacy/response? Abs 0917 #ACR21 #RheumNow @RheumNow https://t.co/FKpCqXpobM https://t.co/WbjjyTIaiG
Dr. Rachel Tate uptoTate ( View Tweet)
MCP, wrist, elbow, shoulder and ankle: Not common sites for #osteoarthritis so consider a metabolic disease like CPPD🧐
@RheumNow #ACR21 #RheumTwitter #MedTwitter https://t.co/utId4ljsZK
sheila RHEUMarampa ( View Tweet)
IV Golimumab efficacy and Early (ED) vs Late (LD) AS
⭐️ED better response than LD with PRO
⭐️Treatment-emergent adverse events/ serious adverse 🔼 LD as compared to ED
Abst #0912 #ACR21 @RheumNow https://t.co/5EaWAvfQ57
swethaann23 swethaann23 ( View Tweet)
Outcomes of COVID-19 in Patients with Rheumatoid Arthritis.
Dr. Akhil Sood ( @AkhilSoodMD) shares the studies presented #ACR21.
https://t.co/yrs8N8XSiS https://t.co/EKHuTS5aDr
Links:
Dr. John Cush RheumNow ( View Tweet)
My "followers" just don't get me. #ACR21 #RheumPix https://t.co/E6gy6RVMBy
Dr. John Cush RheumNow ( View Tweet)
Nationwide study - low income - greater length of stay than highest income. Lowest income many be supported but those who do not have those resources may have an increased length of stay in children hospitalized with pediatric #lupus @dsoulsMD @rheumnow #ACR21 abst#0768 https://t.co/j7VDpVW7ND
Bella Mehta bella_mehta ( View Tweet)
