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RheumNow Podcast – Uppers and Downers

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com.

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ACR, guidance, guidelines

ACR Updates COVID-19 Vaccine Guidance- April 2021

d ACR COVID-19 Vaccine Clinical Guidance Task Force

The ACR COVID-19 Vaccine Clinical Guidance was originally published on February 8, 2021 and updated on March 4, 2021. On April 28, 2021, new recommendations were added regarding mycophenolate, methotrexate, acetaminophen, and NSAID timing considerations,  

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AE, Side effects

Predictors of Methotrexate Toxicity

d Jack Cush, MD

A metanalysis showed that while adverse events (AEs) are common when methotrexate is used in rheumatoid arthritis or inflammatory arthritis patients, serious AEs ranged from 2.1 to 9.5% and drug discontinuations ranged from 6.7% to 15.5%, mostly due to gastrointestinal events. 

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xray%20spine%20films_0.jpg

Seven Year Delay in Diagnosing Spondyloarthritis

d Jack Cush, MD

A large patient cohort study suggests that the mean diagnostic delay (DD) in European axial spondyloarthritis (axSpA) patients is 7.4 years, moreso in women and younger patients.

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SI AS SpA ACR

Tofacitinib in Ankylosing Spondylitis

d Jack Cush, MD

A phase III trial assessing the efficacy and safety of tofacitinib in adults with with active ankylosing spondylitis (AS) shows that JAK inhibitiion was superior to placebo in a 48 week study.

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New podcast up! Uppers and Downers. https://t.co/kt63YryptW

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News Feature: Predictors of Methotrexate Toxicity https://t.co/HjszwdaxVR

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Did you miss this week’s Tuesday Night Rheumatology? Listen to the playback. https://t.co/yTYkeSY7my

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RheumNow Podcast is Up! – with news of Uppers and Downers. Read about Vaccine success, CKD gout prophylaxis, TOFA in AS & too much IL-17 inhib can be a problem https://t.co/kt63YrQ0Sw Listen iTunes> https://t.co/FHJv01AAbC or Android SoundCloud>>https://t.co/IyYvjkWUc1

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Metanalysis of 9 studies, and 1132 lupus pregnancies shows that hydroxychloroquine treatment significantly reduced the risk of preeclampsia (OR 0.35), pregnancy hypertension (OR0.41)and prematurity (OR 0.55), but no effect on rates of HELLP, DM, Ab https://t.co/P9MXjDpuiO

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News Feature: Golimumab Effective in non-radiographic Axial Spondyloarthritis https://t.co/KWqQLHWIiB

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Check out this issue of Arthritis & Rheumatism from 1961. In addition to the great article by Charles Ragan on the "History of Rheumatoid Factor" (pg 571), thumb thru the pages to see the Ads and what rheumatology looked like 60 years ago. https://t.co/Ed9watO3Dw

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CDC study shows that adults >65yrs who are fully vaccinated (w/ Pfizer or Moderna) showed 94% drop in COVID-19 hospitalization (64for among partially vaccinated adults) https://t.co/iJrbiNJg2r

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Will you be attending our Tuesday Night Rheumatology series? Events and topics linked below. Sign up today! https://t.co/ugGaPvBsLD

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Gout Prophylaxis in patients with severe CKD? Metanalysis of 33 studies suggests 1) lack of good data guidance; 3) Colchicind is associated w/ toxicity w/ CKD (neuromyopathy, rhabdomyolysis; 3) anakinra - works, expensive, little/no toxicity https://t.co/VhI0wRC0VO

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News Feature: Search Tofacitinib in Ankylosing Spondylitis https://t.co/cTRvB3cvsh

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Get a Clue - to the Dx of FM https://t.co/LRC7e8PPla

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News Feature: Psoriatic Pregnancies Pose Risks to the Mother, Not Child https://t.co/kZE2yLEvm7

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News Feature: Dual IL-17 Targeting is Effective but has More Candidiasis https://t.co/uDNx65PcC4

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JAMA Dermatology features a case of EGPA - 50 yoM with pruritic rash (legs and arms), asthma, high fevers. His medical history included uncontrollable asthma, WBC 22.9K, marked eosinophilia (9860), neg ANCA, ANA, etc. Bx= LCV w/ Eos. Rx w/ Pred https://t.co/TqANjKV2T9

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