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CMC1, thumb, hand, xray

Little Effect with Multimodal Treatment of CMC1 Osteoarthritis

d Jack Cush, MD

A randomized clinical trial of patients with CMC1 osteoarthritis shows modest benefits when a combination of conservative treatments (education, splinting, hand exercises, 1% diclofenac sodium gel) was used compared to education alone. While there were small to medium benefits with regard to hand function, there was no benefit in pain outcomes. 

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back, LBP, spine, AS

Golimumab Effective in non-radiographic Axial Spondyloarthritis

d Jack Cush, MD

The GO-AHEAD study was designed to assess the long-term efficacy and safety of golimumab (GLM) in non-radiographic axial spondyloarthritis (nr-axSpA).  After the 16-week, placebo [PBO]-controlled double-blind phase, 189/198 (95.5%) entered the long-term extension (OLE) for 36 weeks wherein G

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Take a look at our COVID-19 section of the site to see all articles published on this virus. https://t.co/TiB7739ONL

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Dr. John Cush RheumNow ( View Tweet)

Drug interactions w/ JAK inhibitors - Retrospective analysis of 152,853 pts found ~10% that could have interaction w/ strong OAT3 inhib (<0.1%), CYP3A4 (3%) or CYP3A4 and CYP2C19 inhib (11%) (like lovastatin, prozac, amiodarone, EES, Diflucan) https://t.co/tZztU6cddb

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Expansive differential diagnosis list of Spondyloarthritis/Sacroiliitis Mimics. Free read from Frontiers of Medicine; Early imaging is key to early diagnosis but may lead to misdiagnosis too. https://t.co/N3Vm0MxH9m https://t.co/hxBa065CMV

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Dr. John Cush RheumNow ( View Tweet)
Tuesday Night Rheumatology is tonight--will you be there? https://t.co/lpOUOqhnIE https://t.co/bbUxe5IU4E

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Dr. John Cush RheumNow ( View Tweet)
Analysis of Taiwans National Health Insurance Database, shows from 4.5 children (<18yrs), 23% received steroid burst < 14 days (URI, allergies, asthma) and shows higher 30 rates of GI Bleed (IRR 1.4), Sepsis (2.02), & pneumonia (2.19) https://t.co/ReuNP1C8ww

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Dr. John Cush RheumNow ( View Tweet)

News Feature: Modest Benefit of Multimodal Treatments of CMC1 Osteoarthritis https://t.co/DRR78wyqDz https://t.co/voIsmPHvAf

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Dr. John Cush RheumNow ( View Tweet)
Rheums: Got a Rheumatology question or case for Jack Cush? Record it here and we'll feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. https://t.co/wzNmOzH4VE https://t.co/UYWPeOvdd7

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News Feature: Lupus Activity Affects Mortality https://t.co/lxWAHro0LK https://t.co/oIfLqCWSzI

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Dr. John Cush RheumNow ( View Tweet)
Good Patient Focused overview of Raynauds phenomenon vs Raynauds disease. Not all blue fingers are Raynauds! "Diagnosing and treating Raynaud’s disease" https://t.co/4aKgu2Ika7

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CARD8 SNP rs11672725 (OR 3) may be a Genetic Variant for AdultStill’s Disease. AOSD has unregulated NLR3 inflammasome activity. Study of 66 AOSD & 128 controls, showed AOSD to have low CARD8, higher caspase-1, IL-1β and IL-18; more systemic Sxs https://t.co/rpypR4cLfM

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Hydroxychloroquine related hyperpigmentation appears as Blue or black discoloration of skin or mucosa, occurs in 7-30%; Recent report says ~5%; Risk factors include steroids, bruising, anti-coagulants and trauma - theyr slow to resolve if you D/C https://t.co/aTSBopIEQN

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Dr. J Curtis discussing ACR’s COVID Vaccine guidance. Testing for antibodies may not be necessary at this time as common lab tests differ in what they target. #RNL2021 https://t.co/Xd0DYiwZEg
Robert B Chao, MD doctorRBC ( View Tweet)
Sign up for our Tuesday Night Rheumatology this week featuring lectures and talks presented at RheumNow Live 2021. #RNL2021 https://t.co/lpOUOqhnIE https://t.co/f1dSTWfOsX

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Coconspirators: RA and Lung Disease Download this week's RheumNow podcast, where Dr. Cush reviews the news and journal articles for the last week. https://t.co/MJbfJANWwt https://t.co/PUqewOvBjZ

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Clinical pearl: Bisphosphonates can cause posterior iritis (consider this in patients with negative labs and long term use of bisphosphonates.) Dr. Wang #RNL2021 @RheumNow

Dr. Rachel Tate uptoTate ( View Tweet)

Lilly has reported clinical success with Baricitinib (JAK inhibitor) in patients with alopecia. Two studies (BRAVE-AA1 and BRAVE-AA2) show statistically significant improvement in scalp hair regrowth with baricitinib compared to placebo. https://t.co/D0GE2cSzDZ

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Dr. John Cush RheumNow ( View Tweet)

Register for Tuesday Night Rheumatology. This will feature excerpts from: Future Therapies in RA - Dr. Roy Fleischmann Difficult RA - Dr. Maya Buch RA Treatment Paradigms: EULAR 2019 and ACR 2020 Guidelines - Dr. Alan Matsumoto https://t.co/lpOUOqhnIE #RNL2021 #RheumNow https://t.co/9kdaJ3vfSd

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Dr. John Cush RheumNow ( View Tweet)
"Lupus panniculitis appears like this and feels like wood! But... don’t forget about ddx of possible subcutaneous panniculitic T-cell lymphoma. #RNL2021" Thanks Dr. Robert Chao @doctorRBC for the great #RNL2021 coverage.

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